Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease

Neuroprotective effects of a natural antioxidant tangeretin, a citrus flavonoid, were elucidated in the 6-hydroxydopamine (6-OHDA) lesion rat model of Parkinson's disease (PD), after bioavailability studies. Following the chronic oral administration (10 mg/kg/day for 28 days), significant level...

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Veröffentlicht in:	Neuroreport 2001-12, Vol.12 (17), p.3871-3875
Hauptverfasser:	Datla, Krishna P, Christidou, Maria, Widmer, William W, Rooprai, Harcharan K, Dexter, David T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiology Brain - drug effects Brain - metabolism Brain - pathology Cell Count Cell Survival - drug effects Cell Survival - physiology Disease Models, Animal Dopamine - metabolism Flavones Flavonoids - blood Flavonoids - pharmacokinetics Immunohistochemistry Male Medical sciences Neostriatum - drug effects Neostriatum - metabolism Neostriatum - pathology Neurons - drug effects Neurons - metabolism Neurons - pathology Neuropharmacology Neuroprotective agent Neuroprotective Agents - blood Neuroprotective Agents - pharmacokinetics Oxidopamine - pharmacology Parkinsonian Disorders - drug therapy Parkinsonian Disorders - metabolism Parkinsonian Disorders - pathology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Substantia Nigra - drug effects Substantia Nigra - metabolism Substantia Nigra - pathology tangeretin Tyrosine 3-Monooxygenase - metabolism Viscera - drug effects Viscera - metabolism
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