Apamin-induced irregular firing in vitro and irregular single-spike firing observed in vivo in dopamine neurons is chaotic

Dopamine neurons of the substantia nigra often fire action potentials irregularly in vivo, but in vitro fire in a regular, pacemaker-like firing pattern. Bath application of apamin, a blocker of calcium-activated potassium channels, can shift a dopamine neuron from pacemaker-like to irregular firing...

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Veröffentlicht in:	Neuroscience 2001-01, Vol.104 (3), p.829-840
Hauptverfasser:	Lovejoy, L.P, Shepard, P.D, Canavier, C.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Animals Apamin Apamin - pharmacology Biological and medical sciences Biological Clocks - drug effects Biological Clocks - physiology Central nervous system Computer Simulation Dopamine - metabolism Electrophysiology firing pattern Fundamental and applied biological sciences. Psychology Male Models, Neurological Neurons - cytology Neurons - drug effects Neurons - metabolism Neurotoxins - pharmacology noise Nonlinear Dynamics pacemaker Poisson Distribution Potassium Channel Blockers Potassium Channels - metabolism Predictive Value of Tests Rats Rats, Sprague-Dawley substantia nigra Substantia Nigra - cytology Substantia Nigra - drug effects Substantia Nigra - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology temporal coding Vertebrates: nervous system and sense organs
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