The Cholesterol-Regulated StarD4 Gene Encodes a StAR-Related Lipid Transfer Protein with Two Closely Related Homologues, StarD5 and StarD6

Using cDNA microarrays, we identified StarD4 as a gene whose expression decreased more than 2-fold in the livers of mice fed a high-cholesterol diet. StarD4 expression in cultured 3T3 cells was also sterol-regulated, and known sterol regulatory element binding protein (SREBP)-target genes showed coo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-05, Vol.99 (10), p.6943-6948
Hauptverfasser:	Soccio, Raymond E., Adams, Rachel M., Romanowski, Michael J., Sehayek, Ephraim, Burley, Stephen K., Breslow, Jan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Amino Acid Sequence Animals Base Sequence Biological Sciences Carrier Proteins - genetics Carrier Proteins - metabolism CCAAT-Enhancer-Binding Proteins - metabolism Cholesterol Cholesterol - metabolism Cholesterol, Dietary - metabolism Cholesterols Complementary DNA Cultured cells Deoxyribonucleic acid DNA DNA, Complementary DNA-Binding Proteins - metabolism Gene Expression Regulation Genetics Humans Lipids Liver Liver - metabolism Male Membrane Transport Proteins Mice Mice, Inbred C57BL MLN64 gene Molecular Sequence Data Oligonucleotide Array Sequence Analysis - methods Open reading frames Phosphoproteins - genetics Proteins Rodents Sequence Homology, Amino Acid StarD4 gene StarD5 gene StarD6 gene Sterol Regulatory Element Binding Protein 1 Sterols Studies Transcription Factors Untranslated regions
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