Resistance to UV-induced cell-killing in nucleophosmin/B23 over-expressed NIH 3T3 fibroblasts: enhancement of DNA repair and up-regulation of PCNA in association with nucleophosmin/B23 over-expression

Nucleophosmin/B23 was rapidly up-regulated after UV irradiation as p53, PCNA and c-Jun. UV induction of nucleophosmin/B23 was evidently increased at 3 h post-irradiation, and reached a maximum at 12 h, and remained high for at least 24 h. Over-expression of nucleophosmin/B23 made cells more resistan...

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Veröffentlicht in:	Carcinogenesis (New York) 2002-01, Vol.23 (1), p.93-100
Hauptverfasser:	Wu, Ming H., Chang, Jei H., Yung, Benjamin Y.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Apoptosis - radiation effects Biological and medical sciences Biological effects of radiation Blotting, Western CAT Cell Death - radiation effects Cell Division - radiation effects Cell Survival - radiation effects chloramphenicol acetyltransferase DNA Repair - genetics Dose-Response Relationship, Radiation ECL enhanced chemiluminescence reaction Flow Cytometry Fundamental and applied biological sciences. Psychology interferon regulatory factor-1 Ionizing radiations IRF-1 mAb Mice monoclonal antibody NER Nuclear Proteins - genetics Nuclear Proteins - metabolism nucleophosmin/B23 protein nucleotide excision repair PCNA polyvinylidene difluoride Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism proliferating cellular nuclear antigen Promoter Regions, Genetic - genetics PVDF RNA, Messenger - genetics RNA, Messenger - metabolism SDS-PAGE sodium dodecyl sulfate polyacrylamide gel electrophoresis TBST Time Factors Tissues, organs and organisms biophysics Tris-buffered saline/Tween 20 ultraviolet Ultraviolet Rays Up-Regulation - radiation effects Yin Yang 1 YY 1
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