Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

The metabolic fate of 3-butene-1,2-diol (BDD), a secondary metabolite of the industrial carcinogen, 1,3-butadiene, is unclear. The current study characterizes BDD oxidation to hydroxymethylvinyl ketone (HMVK), a reactive Michael acceptor. Because of its instability in aqueous medium, HMVK was trappe...

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Veröffentlicht in:	Chemical research in toxicology 2001-12, Vol.14 (12), p.1590-1595
Hauptverfasser:	Krause, Renee J, Kemper, Raymond A, Elfarra, Adnan A
Format:	Artikel
Sprache:	eng
Schlagworte:	3-butene-1,2-diol Adult Animals Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism DNA, Complementary - genetics Gas Chromatography-Mass Spectrometry Glutathione - metabolism Glycols - metabolism Humans hydroxymethylvinyl ketone Ketones - metabolism Male Mice Microsomes, Liver - enzymology Middle Aged Oxidation-Reduction Rats
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