Evaluation of mRNA expression levels of IL-17A and IL-10 cytokines in cervical cancer
In this study, we evaluated mRNA expression levels of interleukin (IL)-10/IL-17A by quantitative real-time PCR and their clinical importance in cervical cancer. The IL-10 mRNA levels were higher in cervical cancer tissues as compared with corresponding normal tissues (p
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| Veröffentlicht in: | Tumor biology 2016-08, Vol.37 (8), p.10149-10153 |
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| container_issue | 8 |
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| container_title | Tumor biology |
| container_volume | 37 |
| creator | Akhavan, Setareh Safari, Aghdas Azizmohammadi, Sima Azizmohammadi, Susan Aslami, Maysam Yahaghi, Emad Seifoleslami, Mehri |
| description | In this study, we evaluated mRNA expression levels of interleukin (IL)-10/IL-17A by quantitative real-time PCR and their clinical importance in cervical cancer. The IL-10 mRNA levels were higher in cervical cancer tissues as compared with corresponding normal tissues (p |
| doi_str_mv | 10.1007/s13277-016-4882-8 |
| format | Article |
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The IL-10 mRNA levels were higher in cervical cancer tissues as compared with corresponding normal tissues (p < 0.05). Moreover, IL-17A mRNA was significantly increased in cervical cancer tissues than in normal tissues (p < 0.05). Moreover, the high expression level of IL-10 mRNA was markedly related to International League of Gynecology and Obstetrics (FIGO) stage (p = 0.001), but no significant association was found with other clinical factors including age, tumor size, histological grades, and lymph node metastasis. Moreover, high expression levels of IL-17A were not associated with patients' age, tumor size, FIGO stage, and histological grades while IL-17A expression was strongly linked to lymphatic metastasis (p = 0.001). These findings showed that IL-17A might have a crucial role in cervical cancer metastasis. Taken together, IL-17A expression was strongly linked to lymphatic metastasis, indicating that IL-17A might have a crucial role in cervical cancer metastasis. Moreover, our study suggested the association of IL-10 mRNA expression with clinical stage.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-016-4882-8</identifier><identifier>PMID: 26825983</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Cervical cancer ; Cytokines ; Metastasis ; Ribonucleic acid ; RNA ; Studies</subject><ispartof>Tumor biology, 2016-08, Vol.37 (8), p.10149-10153</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26825983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akhavan, Setareh</creatorcontrib><creatorcontrib>Safari, Aghdas</creatorcontrib><creatorcontrib>Azizmohammadi, Sima</creatorcontrib><creatorcontrib>Azizmohammadi, Susan</creatorcontrib><creatorcontrib>Aslami, Maysam</creatorcontrib><creatorcontrib>Yahaghi, Emad</creatorcontrib><creatorcontrib>Seifoleslami, Mehri</creatorcontrib><title>Evaluation of mRNA expression levels of IL-17A and IL-10 cytokines in cervical cancer</title><title>Tumor biology</title><addtitle>Tumour Biol</addtitle><description>In this study, we evaluated mRNA expression levels of interleukin (IL)-10/IL-17A by quantitative real-time PCR and their clinical importance in cervical cancer. The IL-10 mRNA levels were higher in cervical cancer tissues as compared with corresponding normal tissues (p < 0.05). Moreover, IL-17A mRNA was significantly increased in cervical cancer tissues than in normal tissues (p < 0.05). Moreover, the high expression level of IL-10 mRNA was markedly related to International League of Gynecology and Obstetrics (FIGO) stage (p = 0.001), but no significant association was found with other clinical factors including age, tumor size, histological grades, and lymph node metastasis. Moreover, high expression levels of IL-17A were not associated with patients' age, tumor size, FIGO stage, and histological grades while IL-17A expression was strongly linked to lymphatic metastasis (p = 0.001). These findings showed that IL-17A might have a crucial role in cervical cancer metastasis. Taken together, IL-17A expression was strongly linked to lymphatic metastasis, indicating that IL-17A might have a crucial role in cervical cancer metastasis. Moreover, our study suggested the association of IL-10 mRNA expression with clinical stage.</description><subject>Cervical cancer</subject><subject>Cytokines</subject><subject>Metastasis</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Studies</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LAzEQhoMotlZ_gBcJePESnWSym-yxlKqFoiD2vGTTLGzdj7rZLfbfm6314kWYYV5mHoaZl5BrDvccQD14jkIpBjxmUmvB9AkZcymQAWo4DRo4MCk0jsiF9xsAHiVJfE5GItYiSjSOyWq-M2VvuqKpaZPT6u1lSt3XtnXeD63S7Vzph8liybiaUlOvDxKo3XfNR1E7T4uaWtfuCmtKak0d9CU5y03p3dWxTsjqcf4-e2bL16fFbLpkW6FExwyXOTphshiH22S-hsglFpWxXHCb5UoA2lxqmaCMYpHZEBoxk4B5YgAn5O5n77ZtPnvnu7QqvHVlaWrX9D7lGoWIUIb8H-UyuBLLAb39g26avq3DIwcKlAxooG6OVJ9Vbp1u26Iy7T799Ra_AZ3Rd7c</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Akhavan, Setareh</creator><creator>Safari, Aghdas</creator><creator>Azizmohammadi, Sima</creator><creator>Azizmohammadi, Susan</creator><creator>Aslami, Maysam</creator><creator>Yahaghi, Emad</creator><creator>Seifoleslami, Mehri</creator><general>Springer Nature B.V</general><scope>NPM</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201608</creationdate><title>Evaluation of mRNA expression levels of IL-17A and IL-10 cytokines in cervical cancer</title><author>Akhavan, Setareh ; Safari, Aghdas ; Azizmohammadi, Sima ; Azizmohammadi, Susan ; Aslami, Maysam ; Yahaghi, Emad ; Seifoleslami, Mehri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p272t-a14f3e2ab6300154fd05e9c37ac121cbf7203cf484934562bc2bc833b403f9a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cervical cancer</topic><topic>Cytokines</topic><topic>Metastasis</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akhavan, Setareh</creatorcontrib><creatorcontrib>Safari, Aghdas</creatorcontrib><creatorcontrib>Azizmohammadi, Sima</creatorcontrib><creatorcontrib>Azizmohammadi, Susan</creatorcontrib><creatorcontrib>Aslami, Maysam</creatorcontrib><creatorcontrib>Yahaghi, Emad</creatorcontrib><creatorcontrib>Seifoleslami, Mehri</creatorcontrib><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akhavan, Setareh</au><au>Safari, Aghdas</au><au>Azizmohammadi, Sima</au><au>Azizmohammadi, Susan</au><au>Aslami, Maysam</au><au>Yahaghi, Emad</au><au>Seifoleslami, Mehri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of mRNA expression levels of IL-17A and IL-10 cytokines in cervical cancer</atitle><jtitle>Tumor biology</jtitle><addtitle>Tumour Biol</addtitle><date>2016-08</date><risdate>2016</risdate><volume>37</volume><issue>8</issue><spage>10149</spage><epage>10153</epage><pages>10149-10153</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>In this study, we evaluated mRNA expression levels of interleukin (IL)-10/IL-17A by quantitative real-time PCR and their clinical importance in cervical cancer. The IL-10 mRNA levels were higher in cervical cancer tissues as compared with corresponding normal tissues (p < 0.05). Moreover, IL-17A mRNA was significantly increased in cervical cancer tissues than in normal tissues (p < 0.05). Moreover, the high expression level of IL-10 mRNA was markedly related to International League of Gynecology and Obstetrics (FIGO) stage (p = 0.001), but no significant association was found with other clinical factors including age, tumor size, histological grades, and lymph node metastasis. Moreover, high expression levels of IL-17A were not associated with patients' age, tumor size, FIGO stage, and histological grades while IL-17A expression was strongly linked to lymphatic metastasis (p = 0.001). These findings showed that IL-17A might have a crucial role in cervical cancer metastasis. Taken together, IL-17A expression was strongly linked to lymphatic metastasis, indicating that IL-17A might have a crucial role in cervical cancer metastasis. 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| subjects | Cervical cancer Cytokines Metastasis Ribonucleic acid RNA Studies |
| title | Evaluation of mRNA expression levels of IL-17A and IL-10 cytokines in cervical cancer |
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