Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2Rγnull Immunodeficient Mice

A current pressing need in cancer immunology is the development of preclinical model systems that are immunocompetent for the study of human tumors. Here, we report the development of a humanized murine model that can be used to analyze the pharmacodynamics and antitumor properties of immunostimulat...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2015-09, Vol.75 (17), p.3466-3478
Hauptverfasser:	Sanmamed, Miguel F, Rodriguez, Inmaculada, Schalper, Kurt A, Oñate, Carmen, Azpilikueta, Arantza, Rodriguez-Ruiz, Maria E, Morales-Kastresana, Aizea, Labiano, Sara, Pérez-Gracia, Jose L, Martín-Algarra, Salvador, Alfaro, Carlos, Mazzolini, Guillermo, Sarno, Francesca, Hidalgo, Manuel, Korman, Alan J, Jure-Kunkel, Maria, Melero, Ignacio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Colorectal Neoplasms - drug therapy Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology Graft vs Host Disease - immunology Graft vs Host Disease - pathology HT29 Cells Humans Interleukin Receptor Common gamma Subunit - genetics Interleukin Receptor Common gamma Subunit - immunology Leukocytes, Mononuclear - immunology Lymphocyte Activation - immunology Mice Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - biosynthesis Programmed Cell Death 1 Receptor - immunology T-Lymphocytes - drug effects T-Lymphocytes - pathology Tumor Necrosis Factor Receptor Superfamily, Member 9 - antagonists & inhibitors Tumor Necrosis Factor Receptor Superfamily, Member 9 - biosynthesis Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology
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