Effects of aflibercept on primary RPE cells: toxicity, wound healing, uptake and phagocytosis

Background/aim Anti-VEGF treatment is the therapy of choice in age-related macular degeneration, and is also applied in diabetic macular oedema or retinal vein occlusion. Recently, the fusion protein, aflibercept, has been approved for therapeutic use. In this study, we investigate the effects of af...

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Veröffentlicht in:	British journal of ophthalmology 2014-10, Vol.98 (10), p.1448-1452
Hauptverfasser:	Klettner, Alexa, Tahmaz, Nihat, Dithmer, Michaela, Richert, Elisabeth, Roider, Johann
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - toxicity Animals Antibodies, Monoclonal, Humanized - toxicity Bevacizumab Cell Movement - drug effects Cell Survival Cells, Cultured Coloring Agents - metabolism Fluorescent Antibody Technique, Indirect Macular degeneration Microspheres Molecular weight Phagocytosis - drug effects Phenols Photoreceptors Physiology Ranibizumab Receptors, Vascular Endothelial Growth Factor - toxicity Recombinant Fusion Proteins - toxicity Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Signal transduction Swine Toxicity Trypan Blue - metabolism Wound healing Wound Healing - drug effects
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