Selenium Deficiency Mainly Influences Antioxidant Selenoproteins Expression in Broiler Immune Organs
Selenoprotein has many functions in chicken, and the expression of selenoproteins is closely associated with the selenium (Se) level. However, little is known about the expression patterns of selenoproteins in chicken immune organs. Here, we investigated the effect of dietary Se deficiency on the ex...
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| Veröffentlicht in: | Biological trace element research 2016-07, Vol.172 (1), p.209-221 |
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| creator | Yang, Zijiang Ci Liu Chunpeng Liu Xiaohua Teng Shu Li |
| description | Selenoprotein has many functions in chicken, and the expression of selenoproteins is closely associated with the selenium (Se) level. However, little is known about the expression patterns of selenoproteins in chicken immune organs. Here, we investigated the effect of dietary Se deficiency on the expressions of 23 selenoproteins in broiler immune organs. In this study, 150 broilers were randomly divided into two groups (75 chickens per group). The chickens were maintained either on a diet supplemented with Se through the addition of 0.2Â mg/kg of Se (C group) via sodium selenite or on a Se-deficient granulated diet (L group) until the broilers exhibited an onset of exudative diathesis (ED). Following euthanasia, the samples from the immune tissues (including the spleen, thymus, and bursa of Fabricius) were quickly collected, and the messenger RNA (mRNA) expression levels of 23 selenoproteins were examined by real-time quantitative PCR and analyzed using principal component analysis. The results showed that Se deficiency decreased the mRNA levels of 23 selenoproteins in the thymus, spleen, and bursa of the Fabricius tissues of broiler chickens. Furthermore, we found that among 23 selenoproteins, the mRNA levels of Dio1 in the thymus, Txnrd2 in the spleen, and Txnrd3 in the bursa of Fabricius decreased significantly (90.9Â %, 83.3Â %, and 96.8Â %, respectively). In addition, the principal component analysis (PCA) results suggested that Se deficiency mainly influenced the expression of antioxidative selenoproteins, especially glutathione peroxidases (Gpxs), thioredoxin reductases (Txnrds), and iodothyronine deiodinases (Dios) in chicken immune organs. The results of this study are valuable for understanding the relevance of selenoprotein activity in vivo. |
| doi_str_mv | 10.1007/s12011-015-0578-y |
| format | Article |
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However, little is known about the expression patterns of selenoproteins in chicken immune organs. Here, we investigated the effect of dietary Se deficiency on the expressions of 23 selenoproteins in broiler immune organs. In this study, 150 broilers were randomly divided into two groups (75 chickens per group). The chickens were maintained either on a diet supplemented with Se through the addition of 0.2Â mg/kg of Se (C group) via sodium selenite or on a Se-deficient granulated diet (L group) until the broilers exhibited an onset of exudative diathesis (ED). Following euthanasia, the samples from the immune tissues (including the spleen, thymus, and bursa of Fabricius) were quickly collected, and the messenger RNA (mRNA) expression levels of 23 selenoproteins were examined by real-time quantitative PCR and analyzed using principal component analysis. The results showed that Se deficiency decreased the mRNA levels of 23 selenoproteins in the thymus, spleen, and bursa of the Fabricius tissues of broiler chickens. Furthermore, we found that among 23 selenoproteins, the mRNA levels of Dio1 in the thymus, Txnrd2 in the spleen, and Txnrd3 in the bursa of Fabricius decreased significantly (90.9Â %, 83.3Â %, and 96.8Â %, respectively). In addition, the principal component analysis (PCA) results suggested that Se deficiency mainly influenced the expression of antioxidative selenoproteins, especially glutathione peroxidases (Gpxs), thioredoxin reductases (Txnrds), and iodothyronine deiodinases (Dios) in chicken immune organs. The results of this study are valuable for understanding the relevance of selenoprotein activity in vivo.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-015-0578-y</identifier><identifier>PMID: 26631053</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Antioxidants ; Antioxidants - analysis ; Antioxidants - metabolism ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; broiler chickens ; bursa of Fabricius ; Bursa of Fabricius - immunology ; Bursa of Fabricius - metabolism ; Chickens ; diet ; Dietary Supplements ; euthanasia ; glutathione ; Immune system ; Life Sciences ; messenger RNA ; nutrient deficiencies ; Nutrition ; Oncology ; Organs ; peroxidases ; Poultry ; Principal Component Analysis ; Principal components analysis ; Proteins ; quantitative polymerase chain reaction ; Selenium ; Selenium - administration & dosage ; Selenium - deficiency ; Selenium - metabolism ; selenoproteins ; Selenoproteins - analysis ; Selenoproteins - genetics ; sodium selenite ; spleen ; Spleen - immunology ; Spleen - metabolism ; thymus gland ; Thymus Gland - immunology ; Thymus Gland - metabolism ; tissues</subject><ispartof>Biological trace element research, 2016-07, Vol.172 (1), p.209-221</ispartof><rights>Springer Science+Business Media New York 2015</rights><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-fe1f4632edb4f3cd6bf89a87da22c1698b3fdbe30f4b097d2e9338a7724e365e3</citedby><cites>FETCH-LOGICAL-c429t-fe1f4632edb4f3cd6bf89a87da22c1698b3fdbe30f4b097d2e9338a7724e365e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-015-0578-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-015-0578-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26631053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Zijiang</creatorcontrib><creatorcontrib>Ci Liu</creatorcontrib><creatorcontrib>Chunpeng Liu</creatorcontrib><creatorcontrib>Xiaohua Teng</creatorcontrib><creatorcontrib>Shu Li</creatorcontrib><title>Selenium Deficiency Mainly Influences Antioxidant Selenoproteins Expression in Broiler Immune Organs</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>Selenoprotein has many functions in chicken, and the expression of selenoproteins is closely associated with the selenium (Se) level. However, little is known about the expression patterns of selenoproteins in chicken immune organs. Here, we investigated the effect of dietary Se deficiency on the expressions of 23 selenoproteins in broiler immune organs. In this study, 150 broilers were randomly divided into two groups (75 chickens per group). The chickens were maintained either on a diet supplemented with Se through the addition of 0.2Â mg/kg of Se (C group) via sodium selenite or on a Se-deficient granulated diet (L group) until the broilers exhibited an onset of exudative diathesis (ED). Following euthanasia, the samples from the immune tissues (including the spleen, thymus, and bursa of Fabricius) were quickly collected, and the messenger RNA (mRNA) expression levels of 23 selenoproteins were examined by real-time quantitative PCR and analyzed using principal component analysis. The results showed that Se deficiency decreased the mRNA levels of 23 selenoproteins in the thymus, spleen, and bursa of the Fabricius tissues of broiler chickens. Furthermore, we found that among 23 selenoproteins, the mRNA levels of Dio1 in the thymus, Txnrd2 in the spleen, and Txnrd3 in the bursa of Fabricius decreased significantly (90.9Â %, 83.3Â %, and 96.8Â %, respectively). In addition, the principal component analysis (PCA) results suggested that Se deficiency mainly influenced the expression of antioxidative selenoproteins, especially glutathione peroxidases (Gpxs), thioredoxin reductases (Txnrds), and iodothyronine deiodinases (Dios) in chicken immune organs. The results of this study are valuable for understanding the relevance of selenoprotein activity in vivo.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - analysis</subject><subject>Antioxidants - metabolism</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>broiler chickens</subject><subject>bursa of Fabricius</subject><subject>Bursa of Fabricius - immunology</subject><subject>Bursa of Fabricius - metabolism</subject><subject>Chickens</subject><subject>diet</subject><subject>Dietary Supplements</subject><subject>euthanasia</subject><subject>glutathione</subject><subject>Immune system</subject><subject>Life Sciences</subject><subject>messenger RNA</subject><subject>nutrient deficiencies</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Organs</subject><subject>peroxidases</subject><subject>Poultry</subject><subject>Principal Component Analysis</subject><subject>Principal components analysis</subject><subject>Proteins</subject><subject>quantitative polymerase chain reaction</subject><subject>Selenium</subject><subject>Selenium - administration & dosage</subject><subject>Selenium - deficiency</subject><subject>Selenium - metabolism</subject><subject>selenoproteins</subject><subject>Selenoproteins - analysis</subject><subject>Selenoproteins - genetics</subject><subject>sodium selenite</subject><subject>spleen</subject><subject>Spleen - immunology</subject><subject>Spleen - metabolism</subject><subject>thymus gland</subject><subject>Thymus Gland - immunology</subject><subject>Thymus Gland - metabolism</subject><subject>tissues</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc1u1DAURi0EokPhAdiAJTbdpPg3tpelFDpSURela8tJrkeuEmewE6l5ezxNQYhFu7El-3zftXUQek_JKSVEfc6UEUorQmVFpNLV8gJtqJSmIoqRl2hDaM0rYbQ4Qm9yviOEKmb4a3TE6ppTIvkGdTfQQwzzgL-CD22A2C74hwuxX_A2-n4uB5DxWZzCeB86Fyf8kBj3aZwgxIwv7vcJcg5jxCHiL2kMPSS8HYY5Ar5OOxfzW_TKuz7Du8f9GN1-u_h5flldXX_fnp9dVa1gZqo8UC9qzqBrhOdtVzdeG6dV5xhraW10w33XACdeNMSojoHhXDulmABeS-DH6GTtLY_7NUOe7BByC33vIoxztlRzxoRmQj6PKiOE4qxWBf30H3o3zimWjxworoxWkhSKrlSbxpwTeLtPYXBpsZTYgy272rLFlj3YskvJfHhsnpsBur-JP3oKwFYgl6u4g_TP6CdaP64h70brdilke3tToJqQskou-G9Acqm6</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Yang, Zijiang</creator><creator>Ci Liu</creator><creator>Chunpeng Liu</creator><creator>Xiaohua Teng</creator><creator>Shu Li</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20160701</creationdate><title>Selenium Deficiency Mainly Influences Antioxidant Selenoproteins Expression in Broiler Immune Organs</title><author>Yang, Zijiang ; Ci Liu ; Chunpeng Liu ; Xiaohua Teng ; Shu Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-fe1f4632edb4f3cd6bf89a87da22c1698b3fdbe30f4b097d2e9338a7724e365e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - analysis</topic><topic>Antioxidants - metabolism</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>broiler chickens</topic><topic>bursa of Fabricius</topic><topic>Bursa of Fabricius - immunology</topic><topic>Bursa of Fabricius - metabolism</topic><topic>Chickens</topic><topic>diet</topic><topic>Dietary Supplements</topic><topic>euthanasia</topic><topic>glutathione</topic><topic>Immune system</topic><topic>Life Sciences</topic><topic>messenger RNA</topic><topic>nutrient deficiencies</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Organs</topic><topic>peroxidases</topic><topic>Poultry</topic><topic>Principal Component Analysis</topic><topic>Principal components analysis</topic><topic>Proteins</topic><topic>quantitative polymerase chain reaction</topic><topic>Selenium</topic><topic>Selenium - administration & dosage</topic><topic>Selenium - deficiency</topic><topic>Selenium - metabolism</topic><topic>selenoproteins</topic><topic>Selenoproteins - analysis</topic><topic>Selenoproteins - genetics</topic><topic>sodium selenite</topic><topic>spleen</topic><topic>Spleen - immunology</topic><topic>Spleen - metabolism</topic><topic>thymus gland</topic><topic>Thymus Gland - immunology</topic><topic>Thymus Gland - metabolism</topic><topic>tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Zijiang</creatorcontrib><creatorcontrib>Ci Liu</creatorcontrib><creatorcontrib>Chunpeng Liu</creatorcontrib><creatorcontrib>Xiaohua Teng</creatorcontrib><creatorcontrib>Shu Li</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Zijiang</au><au>Ci Liu</au><au>Chunpeng Liu</au><au>Xiaohua Teng</au><au>Shu Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selenium Deficiency Mainly Influences Antioxidant Selenoproteins Expression in Broiler Immune Organs</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>172</volume><issue>1</issue><spage>209</spage><epage>221</epage><pages>209-221</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>Selenoprotein has many functions in chicken, and the expression of selenoproteins is closely associated with the selenium (Se) level. However, little is known about the expression patterns of selenoproteins in chicken immune organs. Here, we investigated the effect of dietary Se deficiency on the expressions of 23 selenoproteins in broiler immune organs. In this study, 150 broilers were randomly divided into two groups (75 chickens per group). The chickens were maintained either on a diet supplemented with Se through the addition of 0.2Â mg/kg of Se (C group) via sodium selenite or on a Se-deficient granulated diet (L group) until the broilers exhibited an onset of exudative diathesis (ED). Following euthanasia, the samples from the immune tissues (including the spleen, thymus, and bursa of Fabricius) were quickly collected, and the messenger RNA (mRNA) expression levels of 23 selenoproteins were examined by real-time quantitative PCR and analyzed using principal component analysis. The results showed that Se deficiency decreased the mRNA levels of 23 selenoproteins in the thymus, spleen, and bursa of the Fabricius tissues of broiler chickens. Furthermore, we found that among 23 selenoproteins, the mRNA levels of Dio1 in the thymus, Txnrd2 in the spleen, and Txnrd3 in the bursa of Fabricius decreased significantly (90.9Â %, 83.3Â %, and 96.8Â %, respectively). In addition, the principal component analysis (PCA) results suggested that Se deficiency mainly influenced the expression of antioxidative selenoproteins, especially glutathione peroxidases (Gpxs), thioredoxin reductases (Txnrds), and iodothyronine deiodinases (Dios) in chicken immune organs. The results of this study are valuable for understanding the relevance of selenoprotein activity in vivo.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26631053</pmid><doi>10.1007/s12011-015-0578-y</doi><tpages>13</tpages></addata></record> |
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| subjects | Animals Antioxidants Antioxidants - analysis Antioxidants - metabolism Biochemistry Biomedical and Life Sciences Biotechnology broiler chickens bursa of Fabricius Bursa of Fabricius - immunology Bursa of Fabricius - metabolism Chickens diet Dietary Supplements euthanasia glutathione Immune system Life Sciences messenger RNA nutrient deficiencies Nutrition Oncology Organs peroxidases Poultry Principal Component Analysis Principal components analysis Proteins quantitative polymerase chain reaction Selenium Selenium - administration & dosage Selenium - deficiency Selenium - metabolism selenoproteins Selenoproteins - analysis Selenoproteins - genetics sodium selenite spleen Spleen - immunology Spleen - metabolism thymus gland Thymus Gland - immunology Thymus Gland - metabolism tissues |
| title | Selenium Deficiency Mainly Influences Antioxidant Selenoproteins Expression in Broiler Immune Organs |
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