Dynamics of myosin replacement in skeletal muscle cells

Highly organized thick filaments in skeletal muscle cells are formed from ~300 myosin molecules. Each thick-filament-associated myosin molecule is thought to be constantly exchanged. However, the mechanism of myosin replacement remains unclear, as does the source of myosin for substitution. Here, we...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2015-11, Vol.309 (10), p.C669-C679
Hauptverfasser:	Ojima, Koichi, Ichimura, Emi, Yasukawa, Yuya, Wakamatsu, Jun-Ichi, Nishimura, Takanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells Cells, Cultured Chick Embryo Cytoskeleton Cytosol - chemistry Cytosol - metabolism Gene Expression Regulation - physiology Green Fluorescent Proteins Molecules Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - physiology Musculoskeletal system Myosins - genetics Myosins - metabolism Protein synthesis
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