Cross-sectional analysis of Toll-like receptor variants and bacterial vaginosis in African–American women with pelvic inflammatory disease
Objective Bacterial vaginosis (BV) is a common condition associated with serious complications including pelvic inflammatory disease (PID). However, the pathogenesis of BV is poorly understood. Toll-like receptors (TLR) are responsible for microbial recognition and elimination through inflammatory r...
Gespeichert in:
| Veröffentlicht in: | Sexually transmitted infections 2014-11, Vol.90 (7), p.563-566 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 566 |
|---|---|
| container_issue | 7 |
| container_start_page | 563 |
| container_title | Sexually transmitted infections |
| container_volume | 90 |
| creator | Taylor, Brandie D Darville, Toni Ferrell, Robert E Ness, Roberta B Kelsey, Sheryl F Haggerty, Catherine L |
| description | Objective Bacterial vaginosis (BV) is a common condition associated with serious complications including pelvic inflammatory disease (PID). However, the pathogenesis of BV is poorly understood. Toll-like receptors (TLR) are responsible for microbial recognition and elimination through inflammatory responses. TLR variants have been implicated in infectious and inflammatory diseases and may be involved in BV pathogenesis. We conducted a cross-sectional study to determine if TLR variants are associated with BV. Methods Logistic regression was used to test associations between 14 variants assayed in 6 genes (TLR1, TLR2, TLR4, TLR6, TIRAP and MyD88) and BV/intermediate flora among 192 African–American women with clinical PID from the PID Evaluation and Clinical Health (PEACH) Study. Additionally, we examined associations between variants and endometrial BV-associated anaerobes. To account for multiple comparisons a permutated p |
| doi_str_mv | 10.1136/sextrans-2014-051524 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1832247671</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4026646951</sourcerecordid><originalsourceid>FETCH-LOGICAL-b412t-53f2a8069eafd569de6c684cd0fc5727aed04d6e00c6824fee07eb929b46d8493</originalsourceid><addsrcrecordid>eNqF0s2OFCEQAOCO0bjr6hsYQ2JMvODy1_wcJxP_kk28rOcODYUy0s0IPatz8wG8-YY-iYwzq4kXL1AUH3WgquseU_KCUi4vK3xdip0rZoQKTHraM3GnO6dCMcyZ5HdbzKXGwih-1j2odUMIkao397szJrTQXKrz7vu65FpxBbfEPNuEbFv2NVaUA7rOKeEUPwEq4GC75IJubIl2XmpzHo3WLdDOqaU_xDkfnsUZrUKJzs4_v_1YTfA7RF_yBG2Ny0e0hXQTXXMh2Wmyrege-VjBVnjY3Qs2VXh02i-6969eXq_f4Kt3r9-uV1d4FJQtuOeBWU2kARt8L40H6aQWzpPgesWUBU-El0BISzMRAIiC0TAzCum1MPyie36suy358w7qMkyxOkjJzpB3daCaMyaUVPT_VFJmDOG0b_TpP3STd6V9Z1NKU0UVl6SpJye1Gyfww7bEyZb9cNuSBp6dgK3OptB67GL967RW1BjR3OXRjdPmzy0lw2E4htvhGA7DMRyHg_8CDXavMA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781717360</pqid></control><display><type>article</type><title>Cross-sectional analysis of Toll-like receptor variants and bacterial vaginosis in African–American women with pelvic inflammatory disease</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Taylor, Brandie D ; Darville, Toni ; Ferrell, Robert E ; Ness, Roberta B ; Kelsey, Sheryl F ; Haggerty, Catherine L</creator><creatorcontrib>Taylor, Brandie D ; Darville, Toni ; Ferrell, Robert E ; Ness, Roberta B ; Kelsey, Sheryl F ; Haggerty, Catherine L</creatorcontrib><description>Objective Bacterial vaginosis (BV) is a common condition associated with serious complications including pelvic inflammatory disease (PID). However, the pathogenesis of BV is poorly understood. Toll-like receptors (TLR) are responsible for microbial recognition and elimination through inflammatory responses. TLR variants have been implicated in infectious and inflammatory diseases and may be involved in BV pathogenesis. We conducted a cross-sectional study to determine if TLR variants are associated with BV. Methods Logistic regression was used to test associations between 14 variants assayed in 6 genes (TLR1, TLR2, TLR4, TLR6, TIRAP and MyD88) and BV/intermediate flora among 192 African–American women with clinical PID from the PID Evaluation and Clinical Health (PEACH) Study. Additionally, we examined associations between variants and endometrial BV-associated anaerobes. To account for multiple comparisons a permutated p<0.003 was used to determine statistical significance. Results African–American women with PID carrying the AA genotype for TLR2 SNP rs1898830 had a threefold increased rate of BV/intermediate flora (OR 2.9, 95% CI 1.2 to 7.3). This was not significant after accounting for multiple comparisons (p=0.0201). TLR2 variants rs1898830, rs11938228 and rs3804099 were associated with increased endometrial anaerobic gram-negative rods (p=0.0107, p=0.0076 p=0.0121), anaerobic non-pigmented Gram-negative rods (p=0.0231, p=0.0083, p=0.0044), and anaerobic Gram-positive cocci (p=0.0596, p=0.0640, p=0.1459). Conclusions Among African–American women with PID, we observed trends between TLR2 variants, BV/intermediate flora, and BV-associated microbes. This provides some insight into BV pathogenesis. As not all BV-associated microbes may lead to pathology, future studies should focus on associations between TLR variants and individual BV-associated microbes.</description><identifier>ISSN: 1368-4973</identifier><identifier>EISSN: 1472-3263</identifier><identifier>DOI: 10.1136/sextrans-2014-051524</identifier><identifier>PMID: 24848367</identifier><language>eng</language><publisher>London: BMJ Publishing Group</publisher><subject>Adult ; African Americans ; Bacteria ; Bacterial diseases ; Bacterial diseases of the genital system ; Biological and medical sciences ; Black or African American - genetics ; Chlamydia ; Cross-Sectional Studies ; Endometrium ; Epidemiology. Vaccinations ; Fallopian tubes ; Female ; General aspects ; Genetic Predisposition to Disease ; Genotype ; Gonorrhea ; Human bacterial diseases ; Human infectious diseases. Experimental studies and models ; Humans ; Infectious diseases ; Inflammation ; Inflammatory diseases ; Logistic Models ; Medical sciences ; Membrane Glycoproteins - genetics ; Myeloid Differentiation Factor 88 - genetics ; Pathogens ; Pelvic inflammatory disease ; Pelvic Inflammatory Disease - genetics ; Polymorphism, Single Nucleotide ; Prunus ; Receptors, Interleukin-1 - genetics ; Toll-Like Receptor 1 - genetics ; Toll-Like Receptor 2 - genetics ; Toll-Like Receptor 4 - genetics ; Toll-Like Receptor 6 - genetics ; Toll-Like Receptors - genetics ; Vagina ; Vagina - microbiology ; Vaginosis, Bacterial - genetics ; Womens health ; Young Adult</subject><ispartof>Sexually transmitted infections, 2014-11, Vol.90 (7), p.563-566</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>2015 INIST-CNRS</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2014 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://sti.bmj.com/content/90/7/563.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://sti.bmj.com/content/90/7/563.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,778,782,23558,27911,27912,77355,77386</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28871994$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24848367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taylor, Brandie D</creatorcontrib><creatorcontrib>Darville, Toni</creatorcontrib><creatorcontrib>Ferrell, Robert E</creatorcontrib><creatorcontrib>Ness, Roberta B</creatorcontrib><creatorcontrib>Kelsey, Sheryl F</creatorcontrib><creatorcontrib>Haggerty, Catherine L</creatorcontrib><title>Cross-sectional analysis of Toll-like receptor variants and bacterial vaginosis in African–American women with pelvic inflammatory disease</title><title>Sexually transmitted infections</title><addtitle>Sex Transm Infect</addtitle><description>Objective Bacterial vaginosis (BV) is a common condition associated with serious complications including pelvic inflammatory disease (PID). However, the pathogenesis of BV is poorly understood. Toll-like receptors (TLR) are responsible for microbial recognition and elimination through inflammatory responses. TLR variants have been implicated in infectious and inflammatory diseases and may be involved in BV pathogenesis. We conducted a cross-sectional study to determine if TLR variants are associated with BV. Methods Logistic regression was used to test associations between 14 variants assayed in 6 genes (TLR1, TLR2, TLR4, TLR6, TIRAP and MyD88) and BV/intermediate flora among 192 African–American women with clinical PID from the PID Evaluation and Clinical Health (PEACH) Study. Additionally, we examined associations between variants and endometrial BV-associated anaerobes. To account for multiple comparisons a permutated p<0.003 was used to determine statistical significance. Results African–American women with PID carrying the AA genotype for TLR2 SNP rs1898830 had a threefold increased rate of BV/intermediate flora (OR 2.9, 95% CI 1.2 to 7.3). This was not significant after accounting for multiple comparisons (p=0.0201). TLR2 variants rs1898830, rs11938228 and rs3804099 were associated with increased endometrial anaerobic gram-negative rods (p=0.0107, p=0.0076 p=0.0121), anaerobic non-pigmented Gram-negative rods (p=0.0231, p=0.0083, p=0.0044), and anaerobic Gram-positive cocci (p=0.0596, p=0.0640, p=0.1459). Conclusions Among African–American women with PID, we observed trends between TLR2 variants, BV/intermediate flora, and BV-associated microbes. This provides some insight into BV pathogenesis. As not all BV-associated microbes may lead to pathology, future studies should focus on associations between TLR variants and individual BV-associated microbes.</description><subject>Adult</subject><subject>African Americans</subject><subject>Bacteria</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the genital system</subject><subject>Biological and medical sciences</subject><subject>Black or African American - genetics</subject><subject>Chlamydia</subject><subject>Cross-Sectional Studies</subject><subject>Endometrium</subject><subject>Epidemiology. Vaccinations</subject><subject>Fallopian tubes</subject><subject>Female</subject><subject>General aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Gonorrhea</subject><subject>Human bacterial diseases</subject><subject>Human infectious diseases. Experimental studies and models</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Logistic Models</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Myeloid Differentiation Factor 88 - genetics</subject><subject>Pathogens</subject><subject>Pelvic inflammatory disease</subject><subject>Pelvic Inflammatory Disease - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prunus</subject><subject>Receptors, Interleukin-1 - genetics</subject><subject>Toll-Like Receptor 1 - genetics</subject><subject>Toll-Like Receptor 2 - genetics</subject><subject>Toll-Like Receptor 4 - genetics</subject><subject>Toll-Like Receptor 6 - genetics</subject><subject>Toll-Like Receptors - genetics</subject><subject>Vagina</subject><subject>Vagina - microbiology</subject><subject>Vaginosis, Bacterial - genetics</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>1368-4973</issn><issn>1472-3263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0s2OFCEQAOCO0bjr6hsYQ2JMvODy1_wcJxP_kk28rOcODYUy0s0IPatz8wG8-YY-iYwzq4kXL1AUH3WgquseU_KCUi4vK3xdip0rZoQKTHraM3GnO6dCMcyZ5HdbzKXGwih-1j2odUMIkao397szJrTQXKrz7vu65FpxBbfEPNuEbFv2NVaUA7rOKeEUPwEq4GC75IJubIl2XmpzHo3WLdDOqaU_xDkfnsUZrUKJzs4_v_1YTfA7RF_yBG2Ny0e0hXQTXXMh2Wmyrege-VjBVnjY3Qs2VXh02i-6969eXq_f4Kt3r9-uV1d4FJQtuOeBWU2kARt8L40H6aQWzpPgesWUBU-El0BISzMRAIiC0TAzCum1MPyie36suy358w7qMkyxOkjJzpB3daCaMyaUVPT_VFJmDOG0b_TpP3STd6V9Z1NKU0UVl6SpJye1Gyfww7bEyZb9cNuSBp6dgK3OptB67GL967RW1BjR3OXRjdPmzy0lw2E4htvhGA7DMRyHg_8CDXavMA</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Taylor, Brandie D</creator><creator>Darville, Toni</creator><creator>Ferrell, Robert E</creator><creator>Ness, Roberta B</creator><creator>Kelsey, Sheryl F</creator><creator>Haggerty, Catherine L</creator><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20141101</creationdate><title>Cross-sectional analysis of Toll-like receptor variants and bacterial vaginosis in African–American women with pelvic inflammatory disease</title><author>Taylor, Brandie D ; Darville, Toni ; Ferrell, Robert E ; Ness, Roberta B ; Kelsey, Sheryl F ; Haggerty, Catherine L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b412t-53f2a8069eafd569de6c684cd0fc5727aed04d6e00c6824fee07eb929b46d8493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>African Americans</topic><topic>Bacteria</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the genital system</topic><topic>Biological and medical sciences</topic><topic>Black or African American - genetics</topic><topic>Chlamydia</topic><topic>Cross-Sectional Studies</topic><topic>Endometrium</topic><topic>Epidemiology. Vaccinations</topic><topic>Fallopian tubes</topic><topic>Female</topic><topic>General aspects</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Gonorrhea</topic><topic>Human bacterial diseases</topic><topic>Human infectious diseases. Experimental studies and models</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Logistic Models</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Myeloid Differentiation Factor 88 - genetics</topic><topic>Pathogens</topic><topic>Pelvic inflammatory disease</topic><topic>Pelvic Inflammatory Disease - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prunus</topic><topic>Receptors, Interleukin-1 - genetics</topic><topic>Toll-Like Receptor 1 - genetics</topic><topic>Toll-Like Receptor 2 - genetics</topic><topic>Toll-Like Receptor 4 - genetics</topic><topic>Toll-Like Receptor 6 - genetics</topic><topic>Toll-Like Receptors - genetics</topic><topic>Vagina</topic><topic>Vagina - microbiology</topic><topic>Vaginosis, Bacterial - genetics</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taylor, Brandie D</creatorcontrib><creatorcontrib>Darville, Toni</creatorcontrib><creatorcontrib>Ferrell, Robert E</creatorcontrib><creatorcontrib>Ness, Roberta B</creatorcontrib><creatorcontrib>Kelsey, Sheryl F</creatorcontrib><creatorcontrib>Haggerty, Catherine L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Sexually transmitted infections</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taylor, Brandie D</au><au>Darville, Toni</au><au>Ferrell, Robert E</au><au>Ness, Roberta B</au><au>Kelsey, Sheryl F</au><au>Haggerty, Catherine L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cross-sectional analysis of Toll-like receptor variants and bacterial vaginosis in African–American women with pelvic inflammatory disease</atitle><jtitle>Sexually transmitted infections</jtitle><addtitle>Sex Transm Infect</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>90</volume><issue>7</issue><spage>563</spage><epage>566</epage><pages>563-566</pages><issn>1368-4973</issn><eissn>1472-3263</eissn><abstract>Objective Bacterial vaginosis (BV) is a common condition associated with serious complications including pelvic inflammatory disease (PID). However, the pathogenesis of BV is poorly understood. Toll-like receptors (TLR) are responsible for microbial recognition and elimination through inflammatory responses. TLR variants have been implicated in infectious and inflammatory diseases and may be involved in BV pathogenesis. We conducted a cross-sectional study to determine if TLR variants are associated with BV. Methods Logistic regression was used to test associations between 14 variants assayed in 6 genes (TLR1, TLR2, TLR4, TLR6, TIRAP and MyD88) and BV/intermediate flora among 192 African–American women with clinical PID from the PID Evaluation and Clinical Health (PEACH) Study. Additionally, we examined associations between variants and endometrial BV-associated anaerobes. To account for multiple comparisons a permutated p<0.003 was used to determine statistical significance. Results African–American women with PID carrying the AA genotype for TLR2 SNP rs1898830 had a threefold increased rate of BV/intermediate flora (OR 2.9, 95% CI 1.2 to 7.3). This was not significant after accounting for multiple comparisons (p=0.0201). TLR2 variants rs1898830, rs11938228 and rs3804099 were associated with increased endometrial anaerobic gram-negative rods (p=0.0107, p=0.0076 p=0.0121), anaerobic non-pigmented Gram-negative rods (p=0.0231, p=0.0083, p=0.0044), and anaerobic Gram-positive cocci (p=0.0596, p=0.0640, p=0.1459). Conclusions Among African–American women with PID, we observed trends between TLR2 variants, BV/intermediate flora, and BV-associated microbes. This provides some insight into BV pathogenesis. As not all BV-associated microbes may lead to pathology, future studies should focus on associations between TLR variants and individual BV-associated microbes.</abstract><cop>London</cop><pub>BMJ Publishing Group</pub><pmid>24848367</pmid><doi>10.1136/sextrans-2014-051524</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1368-4973 |
| ispartof | Sexually transmitted infections, 2014-11, Vol.90 (7), p.563-566 |
| issn | 1368-4973 1472-3263 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1832247671 |
| source | MEDLINE; BMJ Journals - NESLi2 |
| subjects | Adult African Americans Bacteria Bacterial diseases Bacterial diseases of the genital system Biological and medical sciences Black or African American - genetics Chlamydia Cross-Sectional Studies Endometrium Epidemiology. Vaccinations Fallopian tubes Female General aspects Genetic Predisposition to Disease Genotype Gonorrhea Human bacterial diseases Human infectious diseases. Experimental studies and models Humans Infectious diseases Inflammation Inflammatory diseases Logistic Models Medical sciences Membrane Glycoproteins - genetics Myeloid Differentiation Factor 88 - genetics Pathogens Pelvic inflammatory disease Pelvic Inflammatory Disease - genetics Polymorphism, Single Nucleotide Prunus Receptors, Interleukin-1 - genetics Toll-Like Receptor 1 - genetics Toll-Like Receptor 2 - genetics Toll-Like Receptor 4 - genetics Toll-Like Receptor 6 - genetics Toll-Like Receptors - genetics Vagina Vagina - microbiology Vaginosis, Bacterial - genetics Womens health Young Adult |
| title | Cross-sectional analysis of Toll-like receptor variants and bacterial vaginosis in African–American women with pelvic inflammatory disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T05%3A45%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cross-sectional%20analysis%20of%20Toll-like%20receptor%20variants%20and%20bacterial%20vaginosis%20in%20African%E2%80%93American%20women%20with%20pelvic%20inflammatory%20disease&rft.jtitle=Sexually%20transmitted%20infections&rft.au=Taylor,%20Brandie%20D&rft.date=2014-11-01&rft.volume=90&rft.issue=7&rft.spage=563&rft.epage=566&rft.pages=563-566&rft.issn=1368-4973&rft.eissn=1472-3263&rft_id=info:doi/10.1136/sextrans-2014-051524&rft_dat=%3Cproquest_pubme%3E4026646951%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1781717360&rft_id=info:pmid/24848367&rfr_iscdi=true |