Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation

All-trans retinoic acid (ATRA)-based cell differentiation therapy has been successful in treating acute promyelocytic leukemia, a unique subtype of acute myeloid leukemia (AML). However, other subtypes of AML display resistance to ATRA-based treatment. In this study, we screened natural, plant-deriv...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-05, Vol.76 (9), p.2698-2709
Hauptverfasser:	Yu, Zu-Yin, Xiao, He, Wang, Li-Mei, Shen, Xing, Jing, Yu, Wang, Lin, Sun, Wen-Feng, Zhang, Yan-Feng, Cui, Yu, Shan, Ya-Jun, Zhou, Wen-Bing, Xing, Shuang, Xiong, Guo-Lin, Liu, Xiao-Lan, Dong, Bo, Feng, Jian-Nan, Wang, Li-Sheng, Luo, Qing-Liang, Zhao, Qin-Shi, Cong, Yu-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - pharmacology Blotting, Western Cell Differentiation - drug effects Diterpenes - pharmacology Enzyme Activation - drug effects Humans Leukemia, Myeloid - pathology Male Mice Mice, Inbred C57BL Phytotherapy - methods Protein Kinase C - drug effects Real-Time Polymerase Chain Reaction Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
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