Antagonizing Integrin beta 3 Increases Immunosuppression in Cancer

Integrin beta 3 activation regulates the balance between antitumor and protumor immune cells through effects on STAT6/STAT1 signaling, probably explaining the generally poor efficacy of integrin antagonists in the clinic and raising questions about their cancer therapeutic utility. Integrin beta 3 i...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-06, Vol.76 (12), p.3484-3495
Hauptverfasser:	Su, Xinming, Esser, Alison K, Amend, Sarah R, Xiang, Jingyu, Xu, Yalin, Ross, Michael H, Fox, Gregory C, Kobayashi, Takayuki, Steri, Veronica, Roomp, Kirsten, Fontana, Francesca, Hurchla, Michelle A, Knolhoff, Brett L, Meyer, Melissa A, Morgan, Elizabeth A, Tomasson, Julia C, Novack, Joshua S, Zou, Wei, Faccio, Roberta, Novack, Deborah V, Robinson, Stephen D, Teitelbaum, Steven L, DeNardo, David G, Schneider, Jochen G, Weilbaecher, Katherine N
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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