Immuno-PET Imaging of Engineered Human T Cells in Tumors

Sensitive in vivo imaging technologies applicable to the clinical setting are still lacking for adoptive T-cell-based immunotherapies, an important gap to fill if mechanisms of tumor rejection or escape are to be understood. Here, we propose a highly sensitive imaging technology to track human TCR-t...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-07, Vol.76 (14), p.4113-4123
Hauptverfasser:	Mall, Sabine, Yusufi, Nahid, Wagner, Ricarda, Klar, Richard, Bianchi, Henrique, Steiger, Katja, Straub, Melanie, Audehm, Stefan, Laitinen, Iina, Aichler, Michaela, Peschel, Christian, Ziegler, Sibylle, Mustafa, Mona, Schwaiger, Markus, D'Alessandria, Calogero, Krackhardt, Angela M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Gene Transfer Techniques Humans Immunologic Memory Immunotherapy, Adoptive Mice Neoplasms - diagnostic imaging Neoplasms - immunology Positron Emission Tomography Computed Tomography - methods Receptors, Antigen, T-Cell - genetics T-Lymphocytes - immunology
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