Capnocytophaga canimorsus bacteremia: clinical features and outcomes from a Helsinki ICU cohort
Background Capnocytophaga canimorsus is a gram‐negative rod capable of causing severe sepsis or septic shock. We studied the characteristics of patients with C. canimorsus bacteremia treated in intensive care unit (ICU). Methods Patients with C. canimorsus bacteremia in the Helsinki University Hospi...
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| Veröffentlicht in: | Acta anaesthesiologica Scandinavica 2016-11, Vol.60 (10), p.1437-1443 |
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| container_title | Acta anaesthesiologica Scandinavica |
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| creator | Hästbacka, J. Hynninen, M. Kolho, E. |
| description | Background
Capnocytophaga canimorsus is a gram‐negative rod capable of causing severe sepsis or septic shock. We studied the characteristics of patients with C. canimorsus bacteremia treated in intensive care unit (ICU).
Methods
Patients with C. canimorsus bacteremia in the Helsinki University Hospital district from 2005 to 2014 were retrospectively reviewed using laboratory database and electronical patient records.
Results
We identified 65 patients with C.canimorsus bacteremia. Of these, 16 (25%) were treated in an ICU. The most commonly affected organ systems were coagulation (94%) and kidney (69%). Mortality of ICU treated patients was 19%. Three survivors underwent lower limb amputations for gangrene. Only 25% of the patients were immune‐compromised, but alcohol abuse was common (69%). All patients had a contact with dogs, but only 37% had a history of a dog‐bite.
Conclusion
Capnocytophaga canimorsus infection may present with severe sepsis or septic shock with organ dysfunction, most frequently coagulopathy and acute kidney injury. Previously recognized risk factors are not always present. A dog in a household may be a sufficient exposure for developing a severe form of the disease. The possibility of C. canimorsus infection should be considered in patients with any contact with dogs, even in immunocompetent patients. |
| doi_str_mv | 10.1111/aas.12752 |
| format | Article |
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Capnocytophaga canimorsus is a gram‐negative rod capable of causing severe sepsis or septic shock. We studied the characteristics of patients with C. canimorsus bacteremia treated in intensive care unit (ICU).
Methods
Patients with C. canimorsus bacteremia in the Helsinki University Hospital district from 2005 to 2014 were retrospectively reviewed using laboratory database and electronical patient records.
Results
We identified 65 patients with C.canimorsus bacteremia. Of these, 16 (25%) were treated in an ICU. The most commonly affected organ systems were coagulation (94%) and kidney (69%). Mortality of ICU treated patients was 19%. Three survivors underwent lower limb amputations for gangrene. Only 25% of the patients were immune‐compromised, but alcohol abuse was common (69%). All patients had a contact with dogs, but only 37% had a history of a dog‐bite.
Conclusion
Capnocytophaga canimorsus infection may present with severe sepsis or septic shock with organ dysfunction, most frequently coagulopathy and acute kidney injury. Previously recognized risk factors are not always present. A dog in a household may be a sufficient exposure for developing a severe form of the disease. The possibility of C. canimorsus infection should be considered in patients with any contact with dogs, even in immunocompetent patients.</description><identifier>ISSN: 0001-5172</identifier><identifier>EISSN: 1399-6576</identifier><identifier>DOI: 10.1111/aas.12752</identifier><identifier>PMID: 27251795</identifier><identifier>CODEN: AANEAB</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; Bacteremia - epidemiology ; Bacteremia - etiology ; Capnocytophaga - isolation & purification ; Capnocytophaga canimorsus ; Cohort Studies ; Dogs ; Female ; Gram-Negative Bacterial Infections - epidemiology ; Gram-Negative Bacterial Infections - etiology ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Mortality ; Retrospective Studies</subject><ispartof>Acta anaesthesiologica Scandinavica, 2016-11, Vol.60 (10), p.1437-1443</ispartof><rights>2016 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2016 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 The Acta Anaesthesiologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5602-d4a51c7de250df4a97153c29d1132fc92ef3e4a299aa854ae246f97fa1a3b093</citedby><cites>FETCH-LOGICAL-c5602-d4a51c7de250df4a97153c29d1132fc92ef3e4a299aa854ae246f97fa1a3b093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faas.12752$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faas.12752$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27251795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hästbacka, J.</creatorcontrib><creatorcontrib>Hynninen, M.</creatorcontrib><creatorcontrib>Kolho, E.</creatorcontrib><title>Capnocytophaga canimorsus bacteremia: clinical features and outcomes from a Helsinki ICU cohort</title><title>Acta anaesthesiologica Scandinavica</title><addtitle>Acta Anaesthesiol. Scand</addtitle><description>Background
Capnocytophaga canimorsus is a gram‐negative rod capable of causing severe sepsis or septic shock. We studied the characteristics of patients with C. canimorsus bacteremia treated in intensive care unit (ICU).
Methods
Patients with C. canimorsus bacteremia in the Helsinki University Hospital district from 2005 to 2014 were retrospectively reviewed using laboratory database and electronical patient records.
Results
We identified 65 patients with C.canimorsus bacteremia. Of these, 16 (25%) were treated in an ICU. The most commonly affected organ systems were coagulation (94%) and kidney (69%). Mortality of ICU treated patients was 19%. Three survivors underwent lower limb amputations for gangrene. Only 25% of the patients were immune‐compromised, but alcohol abuse was common (69%). All patients had a contact with dogs, but only 37% had a history of a dog‐bite.
Conclusion
Capnocytophaga canimorsus infection may present with severe sepsis or septic shock with organ dysfunction, most frequently coagulopathy and acute kidney injury. Previously recognized risk factors are not always present. A dog in a household may be a sufficient exposure for developing a severe form of the disease. The possibility of C. canimorsus infection should be considered in patients with any contact with dogs, even in immunocompetent patients.</description><subject>Animals</subject><subject>Bacteremia - epidemiology</subject><subject>Bacteremia - etiology</subject><subject>Capnocytophaga - isolation & purification</subject><subject>Capnocytophaga canimorsus</subject><subject>Cohort Studies</subject><subject>Dogs</subject><subject>Female</subject><subject>Gram-Negative Bacterial Infections - epidemiology</subject><subject>Gram-Negative Bacterial Infections - etiology</subject><subject>Humans</subject><subject>Intensive Care Units</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Retrospective Studies</subject><issn>0001-5172</issn><issn>1399-6576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0U1LHDEYB_BQWnR9OfQLlEAv9jCal8lk0tu61BdW1FJLj-HZTFKjM5M1mUH32xtd9VAomEt4wu_5Q_gj9JmSfZrPAUDap0wK9gFNKFeqqISsPqIJIYQWgkq2ibZSuskjL5XaQJtMsvysxATpGSz7YFZDWF7DX8AGet-FmMaEF2AGG23n4Ts2re-9gRY7C8MYbcLQNziMgwldHlwMHQZ8Ytvk-1uPT2e_sQnXIQ476JODNtndl3sbXR39uJqdFGcXx6ez6VlhREVY0ZQgqJGNZYI0rgQlqeCGqYZSzpxRzDpuS2BKAdSiBMvKyinpgAJfEMW30d46dhnD3WjToDufjG1b6G0Yk6Y1Z3mFqvIdlFWVYlXNM_36D70JY-zzP56U4DUhos7q21qZGFKK1ull9B3ElaZEP_Wjcz_6uZ9sv7wkjovONm_ytZAMDtbg3rd29f8kPZ3-eo0s1hs-DfbhbQPira4kl0L_OT_W9Kc6v5wfzvWcPwIM8qfs</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Hästbacka, J.</creator><creator>Hynninen, M.</creator><creator>Kolho, E.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>201611</creationdate><title>Capnocytophaga canimorsus bacteremia: clinical features and outcomes from a Helsinki ICU cohort</title><author>Hästbacka, J. ; Hynninen, M. ; Kolho, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5602-d4a51c7de250df4a97153c29d1132fc92ef3e4a299aa854ae246f97fa1a3b093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Bacteremia - epidemiology</topic><topic>Bacteremia - etiology</topic><topic>Capnocytophaga - isolation & purification</topic><topic>Capnocytophaga canimorsus</topic><topic>Cohort Studies</topic><topic>Dogs</topic><topic>Female</topic><topic>Gram-Negative Bacterial Infections - epidemiology</topic><topic>Gram-Negative Bacterial Infections - etiology</topic><topic>Humans</topic><topic>Intensive Care Units</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hästbacka, J.</creatorcontrib><creatorcontrib>Hynninen, M.</creatorcontrib><creatorcontrib>Kolho, E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Acta anaesthesiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hästbacka, J.</au><au>Hynninen, M.</au><au>Kolho, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Capnocytophaga canimorsus bacteremia: clinical features and outcomes from a Helsinki ICU cohort</atitle><jtitle>Acta anaesthesiologica Scandinavica</jtitle><addtitle>Acta Anaesthesiol. Scand</addtitle><date>2016-11</date><risdate>2016</risdate><volume>60</volume><issue>10</issue><spage>1437</spage><epage>1443</epage><pages>1437-1443</pages><issn>0001-5172</issn><eissn>1399-6576</eissn><coden>AANEAB</coden><abstract>Background
Capnocytophaga canimorsus is a gram‐negative rod capable of causing severe sepsis or septic shock. We studied the characteristics of patients with C. canimorsus bacteremia treated in intensive care unit (ICU).
Methods
Patients with C. canimorsus bacteremia in the Helsinki University Hospital district from 2005 to 2014 were retrospectively reviewed using laboratory database and electronical patient records.
Results
We identified 65 patients with C.canimorsus bacteremia. Of these, 16 (25%) were treated in an ICU. The most commonly affected organ systems were coagulation (94%) and kidney (69%). Mortality of ICU treated patients was 19%. Three survivors underwent lower limb amputations for gangrene. Only 25% of the patients were immune‐compromised, but alcohol abuse was common (69%). All patients had a contact with dogs, but only 37% had a history of a dog‐bite.
Conclusion
Capnocytophaga canimorsus infection may present with severe sepsis or septic shock with organ dysfunction, most frequently coagulopathy and acute kidney injury. Previously recognized risk factors are not always present. A dog in a household may be a sufficient exposure for developing a severe form of the disease. The possibility of C. canimorsus infection should be considered in patients with any contact with dogs, even in immunocompetent patients.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27251795</pmid><doi>10.1111/aas.12752</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Bacteremia - epidemiology Bacteremia - etiology Capnocytophaga - isolation & purification Capnocytophaga canimorsus Cohort Studies Dogs Female Gram-Negative Bacterial Infections - epidemiology Gram-Negative Bacterial Infections - etiology Humans Intensive Care Units Male Middle Aged Mortality Retrospective Studies |
| title | Capnocytophaga canimorsus bacteremia: clinical features and outcomes from a Helsinki ICU cohort |
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