Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial

Summary Background Complex perianal fistulas in Crohn's disease are challenging to treat. Allogeneic, expanded, adipose-derived stem cells (Cx601) are a promising new therapeutic approach. We aimed to assess the safety and efficacy of Cx601 for treatment-refractory complex perianal fistulas in...

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Veröffentlicht in:	The Lancet (British edition) 2016-09, Vol.388 (10051), p.1281-1290
Hauptverfasser:	Panés, Julián, Prof, García-Olmo, Damián, MD, Van Assche, Gert, Prof, Colombel, Jean Frederic, Prof, Reinisch, Walter, Prof, Baumgart, Daniel C, Prof, Dignass, Axel, Prof, Nachury, Maria, MD, Ferrante, Marc, Prof, Kazemi-Shirazi, Lili, Prof, Grimaud, Jean C, Prof, de la Portilla, Fernando, Prof, Goldin, Eran, Prof, Richard, Marie Paule, MD, Leselbaum, Anne, MD, Danese, Silvio, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue Adult Aged Biological treatment Clinical trials Combined Modality Therapy Crohn Disease - complications Crohn's disease Double-Blind Method Europe Evidence-Based Medicine Female Humans Inflammation Internal Medicine Israel Male Medical treatment Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells Middle Aged Rectal Fistula - etiology Rectal Fistula - pathology Rectal Fistula - surgery Rectal Fistula - therapy Safety Stem cells Transplantation, Homologous Treatment Outcome Tumor necrosis factor-TNF
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