Malignant Adenomyoepithelioma of the Breast: A Review

Malignant adenomyoepithelioma (MAME) of the breast is a rare lesion characterized by dual population of epithelial and myoepithelial cells which one or both components show malignant features. We report a case of MAME of the breast in a 46‐year‐old woman diagnosed by fine‐needle aspiration with exte...

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Veröffentlicht in:The breast journal 2015-05, Vol.21 (3), p.291-296
Hauptverfasser: Ahmadi, Nasrollah, Negahban, Shahrzad, Aledavood, Azita, Daneshbod, Khosrow, Daneshbod, Yahya
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container_end_page 296
container_issue 3
container_start_page 291
container_title The breast journal
container_volume 21
creator Ahmadi, Nasrollah
Negahban, Shahrzad
Aledavood, Azita
Daneshbod, Khosrow
Daneshbod, Yahya
description Malignant adenomyoepithelioma (MAME) of the breast is a rare lesion characterized by dual population of epithelial and myoepithelial cells which one or both components show malignant features. We report a case of MAME of the breast in a 46‐year‐old woman diagnosed by fine‐needle aspiration with extensive review of the literature. Classification, clinical presentation, cyto‐pathologic, and immunohistochemical features are described. This lesion showed both malignant components of epithelial and myoepithelial cells in cytology and histology. The malignancy was convincingly supported by high mitotic figures, pleomorphism, and invasion in tissue sections. This review of MAMEs showed that cyto‐histologic diagnosis is difficult and should be supported by immunohistochemical study.
doi_str_mv 10.1111/tbj.12390
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subjects Adenomyoepithelioma - pathology
Biopsy, Fine-Needle
Breast Neoplasms - pathology
cytology
Female
fine-needle aspiration
histopathology
Humans
Immunohistochemistry
literature review
malignant adenomyoepithelioma
Middle Aged
title Malignant Adenomyoepithelioma of the Breast: A Review
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