Effect of chromosome location on bacterial mutation rates

In previous comparisons of enterobacterial sequences, synonymous substitution rates were higher in genes closer to the replication terminus, suggesting that mutation rates increase with distance from the replication origin. In order to directly test for the effects of chromosomal location on the rat...

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Veröffentlicht in:	Molecular biology and evolution 2002-01, Vol.19 (1), p.85-92
Hauptverfasser:	Hudson, Richard Ellis, Bergthorsson, Ulfar, Roth, John R, Ochman, Howard
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Bacteria - genetics Chromosomes, Bacterial - genetics Escherichia coli - genetics Escherichia coli - growth & development Gene Order - genetics Kinetics Lac Operon - genetics lacZ gene Mutagenesis - genetics Point Mutation - genetics Replication Origin - genetics Salmonella enterica Salmonella typhimurium - genetics Salmonella typhimurium - growth & development
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