Caspase-mediated Parkin Cleavage in Apoptotic Cell Death

The parkin protein is important for the survival of the neurons that degenerate in Parkinson's disease as demonstrated by disease-causing lesions in the parkin gene. The Chinese hamster ovary and the SH-SY5Y cell line stably expressing recombinant human parkin combined with epitope-specific par...

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Veröffentlicht in:	The Journal of biological chemistry 2002-05, Vol.277 (18), p.15303-15308
Hauptverfasser:	Kahns, Søren, Lykkebo, Simon, Jakobsen, Lene Diness, Nielsen, Morten S., Jensen, Poul Henning
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Animals Apoptosis Caspases - metabolism CHO Cells Cloning, Molecular Cricetinae DNA Primers Humans Ligases - metabolism Mutagenesis, Site-Directed Oligopeptides - chemistry parkin protein Parkinson Disease Peptide Fragments - metabolism Polymerase Chain Reaction Recombinant Proteins - metabolism Ubiquitin-Protein Ligases
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