ERK8, a New Member of the Mitogen-activated Protein Kinase Family

The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. By using the rat ERK7 cDNA to screen a human multiple tissue cDNA library, we identified a new member of the ERK family, ERK8, that shares 69% amino acid sequence identity with ERK7. Northern analysis...

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Veröffentlicht in:	The Journal of biological chemistry 2002-05, Vol.277 (19), p.16733-16743
Hauptverfasser:	Abe, Mark K., Saelzler, Matthew P., Espinosa, Rafael, Kahle, Kristopher T., Hershenson, Marc B., Le Beau, Michelle M., Rosner, Marsha Rich
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Blotting, Northern Blotting, Western Butadienes - pharmacology chromosome 8 Chromosomes, Human, Pair 8 COS Cells DNA, Complementary - metabolism Enzyme Inhibitors - pharmacology ERK8 gene Exons Extracellular Signal-Regulated MAP Kinases Gene Library Glutathione Transferase - metabolism Humans In Situ Hybridization, Fluorescence Introns MAP Kinase Signaling System Mitogen-Activated Protein Kinases - biosynthesis Mitogen-Activated Protein Kinases - chemistry Mitogen-Activated Protein Kinases - metabolism Molecular Sequence Data Nitriles - pharmacology Phylogeny Plasmids - metabolism Precipitin Tests Protein Binding Protein Structure, Tertiary Rats Recombinant Fusion Proteins - metabolism Sequence Homology, Amino Acid Signal Transduction Src protein src-Family Kinases - metabolism Tissue Distribution Transfection
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