Extrathyroidal actions of antithyroid thionamides

Some compounds having thionamide structure inhibit thyroid functions. Such antithyroid thionamides include mercaptomethylimidazole (methimazole), thiourea and propylthiouracil, of which mercaptomethylimidazole is widely used to treat hyperthyroidism. Undesirable side effects develop from these drugs...

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Veröffentlicht in:	Toxicology Letters 2002-03, Vol.128 (1), p.117-127
Hauptverfasser:	Bandyopadhyay, Uday, Biswas, Kausik, Banerjee, Ranajit K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antithyroid Agents - adverse effects Antithyroid Agents - chemistry Antithyroid Agents - metabolism Antithyroid thionamides Biological and medical sciences Blood cells and immune suppression Enzyme Inhibitors - pharmacology Flavin monooxygenase Gastric Acid - metabolism Gastric secretions General aspects. Methods Hearing - drug effects Immunosuppression lactoperoxidase Lactoperoxidase - antagonists & inhibitors Medical sciences Methimazole - adverse effects Methimazole - chemistry Methimazole - metabolism Mice Olfactory Mucosa - drug effects Peroxidase - antagonists & inhibitors Peroxidases Prostaglandin synthase Rats Thioamides - adverse effects Toxicology
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