Integrin alpha 3 beta 1 (CD 49c/29) Is a Cellular Receptor for Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8) Entry into the Target Cells

Integrin alpha 3 beta 1 (CD 49c/29) Is a Cellular Receptor for Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8) Entry into the Target Cells

Human herpesvirus-8 (HHV-8) is implicated in the pathogenesis of Kaposi's sarcoma. HHV-8 envelope glycoprotein B possesses the RGD motif known to interact with integrin molecules, and HHV-8 infectivity was inhibited by RGD peptides, antibodies against RGD-dependent alpha 3 and beta 1 integrins,...

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Veröffentlicht in:Cell 2002-02, Vol.108 (3), p.407-419
Hauptverfasser: Akula, S M, Pramod, N P, Wang, Fu-Zhang, Chandran, B
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Sprache:eng
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FAK protein
glycoprotein B
Human herpesvirus 8
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creator Akula, S M
Pramod, N P
Wang, Fu-Zhang
Chandran, B
description Human herpesvirus-8 (HHV-8) is implicated in the pathogenesis of Kaposi's sarcoma. HHV-8 envelope glycoprotein B possesses the RGD motif known to interact with integrin molecules, and HHV-8 infectivity was inhibited by RGD peptides, antibodies against RGD-dependent alpha 3 and beta 1 integrins, a by soluble alpha 3 beta 1 integrin. Expression of human alpha 3 integrin increased the infectivity of virus for Chinese hamster ovary cells. Anti-gB antibodies immunoprecipitated the virus- alpha 3 and - beta 1 complexes, and virus binding studies suggest a role for alpha 3 beta 1 in HHV-8 entry. Further, HHV-8 infection induced the integrin mediated activation of focal adhesion kinase (FAK). These findings implicate a role for alpha 3 beta 1 integrin and the associated signaling pathways in HHV-8 entry into the target cells.
doi_str_mv 10.1016/S0092-8674(02)00628-1
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subjects FAK protein
glycoprotein B
Human herpesvirus 8
title Integrin alpha 3 beta 1 (CD 49c/29) Is a Cellular Receptor for Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8) Entry into the Target Cells
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