Is AZT/3TC therapy effective against FIV infection or immunopathogenesis?

In vitro and in vivo prophylactic and therapeutic efficacy of AZT/3TC treatment was evaluated against feline immunodeficiency virus (FIV) infection. In vitro studies utilized FIV-infected peripheral blood mononuclear cells (PBMCs) or FIV-infected T-cell lines treated with AZT (azidothymidine) alone,...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2002-03, Vol.85 (3), p.189-204
Hauptverfasser:	Arai, Maki, Earl, Donald D, Yamamoto, Janet K
Format:	Artikel
Sprache:	eng
Schlagworte:	3TC Animals Anti-HIV Agents - adverse effects Anti-HIV Agents - immunology Anti-HIV Agents - therapeutic use Anti-retroviral drugs Antibodies, Viral - blood azidothymidine AZT Cat Diseases - drug therapy Cat Diseases - immunology Cat Diseases - virology Cats CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Drug Synergism Drug Therapy, Combination Feline Acquired Immunodeficiency Syndrome - drug therapy Feline Acquired Immunodeficiency Syndrome - immunology Feline Acquired Immunodeficiency Syndrome - virology Feline immunodeficiency virus Feline immunodeficiency virus (FIV) Flow Cytometry Immunodeficiency Virus, Feline - genetics Immunodeficiency Virus, Feline - immunology Immunodeficiency Virus, Feline - metabolism lamivudine Lamivudine - adverse effects Lamivudine - immunology Lamivudine - therapeutic use Random Allocation Viral Load - veterinary Zidovudine - adverse effects Zidovudine - therapeutic use
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