Glycogen Synthase Kinase-3 Couples AKT-dependent Signaling to the Regulation of p21 super(Cip1) Degradation

Signaling via the phosphoinositide 3-kinase (PI3K)/AKT pathway is crucial for the regulation of endothelial cell (EC) proliferation and survival, which involves the AKT-dependent phosphorylation of the DNA repair protein p21 super(Cip1) at Thr-145. Because p21 super(Cip1) is a short-lived protein wi...

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Veröffentlicht in:	The Journal of biological chemistry 2002-03, Vol.277 (12), p.9684-9689
Hauptverfasser:	Roessig, L, Badorff, C, Holzmann, Y, Zeiher, AM, Dimmeler, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt protein Cip1 protein glycogen synthase kinase 3^b
Online-Zugang:	Volltext
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