Stop Codons Preceded by Rare Arginine Codons Are Efficient Determinants of SsrA Tagging in Escherichia coli

The SsrA or tmRNA quality control system intervenes when ribosomes stall on mRNAs and directs the addition of a C-terminal peptide tag that targets the modified polypeptide for degradation. Although hundreds of SsrA-tagged proteins can be detected in cells when degradation is prevented, most of thes...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-03, Vol.99 (6), p.3440-3445
Hauptverfasser:	Hayes, Christopher S., Bose, Baundauna, Sauer, Robert T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Arginine - genetics Base Sequence Biological Sciences Biology Chemistry Codon, Terminator - genetics Codons Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Expression Regulation, Bacterial Genes, Bacterial - genetics Genetic mutation Gin Messenger RNA Molecular Sequence Data Mutation - genetics Opal Peptides Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Plasmids Protein Biosynthesis Protein Processing, Post-Translational Proteins Regulatory Sequences, Nucleic Acid - genetics ribokinase Ribonucleic acid Ribosomes Ribosomes - metabolism RNA RNA, Bacterial - antagonists & inhibitors RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Transfer, Arg - genetics RNA, Transfer, Arg - metabolism Stop codon Terminator codon tmRNA
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