Quantitation of androgen receptor gene expression in sporadic breast tumors by real-time RT–PCR: evidence that MYC is an AR-regulated gene

Little is known of the function and clinical significance of the androgen receptor (AR) in human breast cancer. Paradoxically, synthetic progestins, such as medroxyprogesterone acetate, are used for second line hormone therapy of breast cancer following tamoxifen failure. A sensitive and accurate as...

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Veröffentlicht in:	Carcinogenesis (New York) 2001-09, Vol.22 (9), p.1521-1526
Hauptverfasser:	Bièche, Ivan, Parfait, Béatrice, Tozlu, Sengül, Lidereau, Rosette, Vidaud, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase Adult Aged Aged, 80 and over androgen receptor Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cyclin D1 - genetics DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics estrogen receptor Estrogen Receptor alpha Estrogen Receptor beta Female Gene Expression Regulation, Neoplastic Genes, erbB-2 - genetics Genes, myc - genetics Genes, Retinoblastoma - genetics Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences medroxyprogesterone acetate Middle Aged MPA MYC gene Nuclear Receptor Coactivators Oncogene Proteins progesterone receptor Prostate-Specific Antigen - genetics Protein Tyrosine Phosphatases - genetics Receptors, Androgen - biosynthesis Receptors, Androgen - genetics Receptors, Estrogen - biosynthesis Receptors, Estrogen - genetics Receptors, Progesterone - biosynthesis Receptors, Progesterone - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics SBR Scarff–Bloom– Richardson Trans-Activators - genetics Transcription Factors Tumors
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