TOXIN EVOLUTION IN SCORPION VENOM: EVIDENCE FOR TOXIN DIVERGENCE UNDER STRONG NEGATIVE SELECTION IN LEIURUS QUINQUESTRIATUS SUBSPECIES
The Buthid scorpion Leiurus quinquestriatus is divided into two sub-species whose region of contact occurs at the Suez Isthmus. L.q. quinquestriatus, found in the North Africa is distinguished from L.q. hebraeus by minor differences in morphology. Despite the very high similarity in body plan, out o...
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| Veröffentlicht in: | Journal of toxicology. Toxin reviews 2001, Vol.20 (3-4), p.229-244 |
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| container_title | Journal of toxicology. Toxin reviews |
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| creator | Smertenko, Andrei Omran, Mohamed Alaa A. Hussey, Patrick J. McVean, Alistair |
| description | The Buthid scorpion Leiurus quinquestriatus is divided into two sub-species whose region of contact occurs at the Suez Isthmus. L.q. quinquestriatus, found in the North Africa is distinguished from L.q. hebraeus by minor differences in morphology. Despite the very high similarity in body plan, out of the 24 toxins isolated from this species none is common to both sub-species, suggesting a degree of molecular divergence not apparent at the morphological level. We show, by comparison with two sets of reference proteins from humans and Old-World monkeys, that divergence of toxins with common structures and functions in these two sub-species has occurred under conditions of strong negative selection. Potential selection pressures responsible for toxin divergence are discussed, including the role of conflicting interests during courtship. |
| doi_str_mv | 10.1081/TXR-100108558 |
| format | Article |
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Toxin reviews</title><description>The Buthid scorpion Leiurus quinquestriatus is divided into two sub-species whose region of contact occurs at the Suez Isthmus. L.q. quinquestriatus, found in the North Africa is distinguished from L.q. hebraeus by minor differences in morphology. Despite the very high similarity in body plan, out of the 24 toxins isolated from this species none is common to both sub-species, suggesting a degree of molecular divergence not apparent at the morphological level. We show, by comparison with two sets of reference proteins from humans and Old-World monkeys, that divergence of toxins with common structures and functions in these two sub-species has occurred under conditions of strong negative selection. Potential selection pressures responsible for toxin divergence are discussed, including the role of conflicting interests during courtship.</description><subject>Animal poisons toxicology. Antivenoms</subject><subject>Biological and medical sciences</subject><subject>Buthidae</subject><subject>Leiurus quinquestriatus</subject><subject>Medical sciences</subject><subject>Scorpiones</subject><subject>Toxicology</subject><issn>1556-9543</issn><issn>0731-3837</issn><issn>1556-9551</issn><issn>1525-6057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp1kDtv2zAUhYWiBZq6HbtraTclfEgm1c2VaYeAKsV6GN4ISiIRB7KVkDYC_4H87tC1kyBDJp7L-51D4njeTwguIaDwqloVAQTA6Siin7wLGEXjII4i-PlVh_ir983aOwAwDWNy4T1V-YpnPlvmaV3xPPPdUCZ5cXPUS5bl__64JZ-yLGH-LC_8Ez_lS1bM_1_W2ZQVflkVeTb3MzafVG7nlyxlyUtgynhd1KW_qHm2qJlj-aRyc1n_LW9Ywln53fuiZW_Vj_M58uoZq5LrIM3nPJmkQYtjvAskQOOGNA0GqNMqDmWnGxhp2FKEdNepFkEco3GoIdIENFRJREBHMAbjJupigkfe71PuvRke9sruxGZtW9X3cquGvRWQIkoACR0YnMDWDNYapcW9WW-kOQgIxLFt4doWr207_tc5WNpW9trIbbu2byYcYkThMZeeuPVWD2YjHwfTd2InD_1gXkz4oyfIO-utkv3utpVGibthb7autw8-9wx9fppD</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Smertenko, Andrei</creator><creator>Omran, Mohamed Alaa A.</creator><creator>Hussey, Patrick J.</creator><creator>McVean, Alistair</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>2001</creationdate><title>TOXIN EVOLUTION IN SCORPION VENOM: EVIDENCE FOR TOXIN DIVERGENCE UNDER STRONG NEGATIVE SELECTION IN LEIURUS QUINQUESTRIATUS SUBSPECIES</title><author>Smertenko, Andrei ; Omran, Mohamed Alaa A. ; Hussey, Patrick J. ; McVean, Alistair</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-a026b7bb302dfe94adfb15f1c822fddec2139264f12f70b8ea270d73306b5d973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animal poisons toxicology. Antivenoms</topic><topic>Biological and medical sciences</topic><topic>Buthidae</topic><topic>Leiurus quinquestriatus</topic><topic>Medical sciences</topic><topic>Scorpiones</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smertenko, Andrei</creatorcontrib><creatorcontrib>Omran, Mohamed Alaa A.</creatorcontrib><creatorcontrib>Hussey, Patrick J.</creatorcontrib><creatorcontrib>McVean, Alistair</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of toxicology. Toxin reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smertenko, Andrei</au><au>Omran, Mohamed Alaa A.</au><au>Hussey, Patrick J.</au><au>McVean, Alistair</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TOXIN EVOLUTION IN SCORPION VENOM: EVIDENCE FOR TOXIN DIVERGENCE UNDER STRONG NEGATIVE SELECTION IN LEIURUS QUINQUESTRIATUS SUBSPECIES</atitle><jtitle>Journal of toxicology. Toxin reviews</jtitle><date>2001</date><risdate>2001</risdate><volume>20</volume><issue>3-4</issue><spage>229</spage><epage>244</epage><pages>229-244</pages><issn>1556-9543</issn><issn>0731-3837</issn><eissn>1556-9551</eissn><eissn>1525-6057</eissn><coden>JTTRD9</coden><abstract>The Buthid scorpion Leiurus quinquestriatus is divided into two sub-species whose region of contact occurs at the Suez Isthmus. 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| ispartof | Journal of toxicology. Toxin reviews, 2001, Vol.20 (3-4), p.229-244 |
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| source | Taylor & Francis Medical Library - CRKN; Access via Taylor & Francis |
| subjects | Animal poisons toxicology. Antivenoms Biological and medical sciences Buthidae Leiurus quinquestriatus Medical sciences Scorpiones Toxicology |
| title | TOXIN EVOLUTION IN SCORPION VENOM: EVIDENCE FOR TOXIN DIVERGENCE UNDER STRONG NEGATIVE SELECTION IN LEIURUS QUINQUESTRIATUS SUBSPECIES |
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