The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice

Cation channels in the DEG/ENaC family are proposed to detect cutaneous stimuli in mammals. We localized one such channel, DRASIC, in several different specialized sensory nerve endings of skin, suggesting it might participate in mechanosensation and/or acid-evoked nociception. Disrupting the mouse...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2001-12, Vol.32 (6), p.1071-1083
Hauptverfasser:	Price, Margaret P, McIlwrath, Sabrina L, Xie, Jinghui, Cheng, Chun, Qiao, Jing, Tarr, Deirdre E, Sluka, Kathleen A, Brennan, Timothy J, Lewin, Gary R, Welsh, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Sensing Ion Channels Acids Animals Behavior, Animal - physiology cation channels DRASIC gene Hot Temperature Mechanoreceptors - physiology Membrane Potentials - physiology Membrane Proteins Mice Mice, Inbred C57BL Mice, Knockout Nerve Endings - physiology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons, Afferent - physiology Nociceptors - physiology Pain - chemically induced Pain - physiopathology Patch-Clamp Techniques Physical Stimulation Recombination, Genetic Sodium Channels - genetics Sodium Channels - metabolism Stimulation, Chemical Touch - physiology
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