Sp3 Represses Gene Expression via the Titration of Promoter-specific Transcription Factors

We have determined previously that Sp3 encodes three distinct gene products as follows: a full-length protein (Sp3) that is an activator of transcription and two isoforms (M1 and M2) derived via internal translational initiation that function as transcriptional repressors. To identify amino acids an...

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Veröffentlicht in:	The Journal of biological chemistry 2002-03, Vol.277 (12), p.9780-9789
Hauptverfasser:	Kennett, Sarah B., Moorefield, K. Scott, Horowitz, Jonathan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Animals Binding, Competitive Cell Line Cell Nucleus - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Gene Expression Genes, MDR - genetics Humans Insecta Mutagenesis, Site-Directed Mutation Plasmids - metabolism Polymerase Chain Reaction Promoter Regions, Genetic Protein Binding Protein Biosynthesis Protein Isoforms Protein Structure, Tertiary Proto-Oncogene Proteins p21(ras) - genetics Sequence Analysis, DNA Sp3 protein Sp3 Transcription Factor TAFII40 protein TAFII70 protein Tetrahydrofolate Dehydrogenase - genetics Time Factors Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation Transfection Tumor Cells, Cultured
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