High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients
Purpose It was hypothesized that patients with chronic obstructive pulmonary disease (COPD) would exhibit a slow muscle deoxygenation (HHb) recovery time when compared with sedentary controls. Methods Neuromuscular electrical stimulation (NMES 40 and 50 mA, 50 Hz, 400 µs) was employed to induce isom...
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| Veröffentlicht in: | European journal of applied physiology 2016-10, Vol.116 (10), p.1899-1910 |
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| creator | Azevedo, Diego de Paiva Medeiros, Wladimir Musetti de Freitas, Flávia Fernandes Manfredi Ferreira Amorim, Cesar Gimenes, Ana Cristina Oliveira Neder, Jose Alberto Chiavegato, Luciana Dias |
| description | Purpose
It was hypothesized that patients with chronic obstructive pulmonary disease (COPD) would exhibit a slow muscle deoxygenation (HHb) recovery time when compared with sedentary controls.
Methods
Neuromuscular electrical stimulation (NMES 40 and 50 mA, 50 Hz, 400 µs) was employed to induce isometric contraction of the quadriceps. Microvascular oxygen extraction (µO
2
EF) and HHb were estimated by near-infrared spectroscopy (NIRS). Recovery kinetic was characterized by measuring the time constant Tau (HHb-τ). Torque and work were measured by isokinetic dynamometry in 13 non-hypoxaemic patients with moderate-to-severe COPD [SpO
2
= 94.1 ± 1.6 %; FEV
1
(% predict) 48.0 ± 9.6; GOLD II–III] and 13 age- and sex-matched sedentary controls.
Results
There was no desaturation in either group during NMES. Torque and work were reduced in COPD versus control for 40 and 50 mA [torque (Nm) 50 mA = 28.9 ± 6.9 vs 46.1 ± 14.2; work (J) 50 mA = 437.2 ± 130.0 vs. 608.3 ± 136.8;
P
|
| doi_str_mv | 10.1007/s00421-016-3442-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1827935048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1819433092</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-37d6c764b463dc1253e8f446d965866d851a4bde57090b0624200d9e9e694c7a3</originalsourceid><addsrcrecordid>eNqNkctu1DAUhiNERUvhAdggS2zYBHyLL0s0FIpUqV3A2vLYJ4NLYg-2QzsPwHuTNKVCSEisfPv-_8j6muYFwW8IxvJtwZhT0mIiWsY5beWj5oRwplvBqHz8sCf6uHlayjXGWFGinjTHVHKhFMcnzc_zsPuK0u1hBxHBbc3W1ZAistGjMqQblMGlH5APKPVonIobAHlYeXtHfgsRanAF2b5CRhGmnBZwGmxGMICrOTg7oFLDON_dZUJEm8ur92g_HyHW8qw56u1Q4Pn9etp8-XD2eXPeXlx-_LR5d9E6LkltmfTCScG3XDDvCO0YqJ5z4bXolBBedcTyrYdOYo23WFBOMfYaNAjNnbTstHm99u5z-j5BqWYMxcEw2AhpKoYoKjXrMFf_gRLNGcOazuirv9DrNOU4f2ShVKeFFEshWSmXUykZerPPYbT5YAg2i06z6jSzTrPoNHLOvLxvnrYj-IfEb38zQFegzE9xB_mP0f9s_QU-mKuN</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1818596768</pqid></control><display><type>article</type><title>High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Azevedo, Diego de Paiva ; Medeiros, Wladimir Musetti ; de Freitas, Flávia Fernandes Manfredi ; Ferreira Amorim, Cesar ; Gimenes, Ana Cristina Oliveira ; Neder, Jose Alberto ; Chiavegato, Luciana Dias</creator><creatorcontrib>Azevedo, Diego de Paiva ; Medeiros, Wladimir Musetti ; de Freitas, Flávia Fernandes Manfredi ; Ferreira Amorim, Cesar ; Gimenes, Ana Cristina Oliveira ; Neder, Jose Alberto ; Chiavegato, Luciana Dias</creatorcontrib><description>Purpose
It was hypothesized that patients with chronic obstructive pulmonary disease (COPD) would exhibit a slow muscle deoxygenation (HHb) recovery time when compared with sedentary controls.
Methods
Neuromuscular electrical stimulation (NMES 40 and 50 mA, 50 Hz, 400 µs) was employed to induce isometric contraction of the quadriceps. Microvascular oxygen extraction (µO
2
EF) and HHb were estimated by near-infrared spectroscopy (NIRS). Recovery kinetic was characterized by measuring the time constant Tau (HHb-τ). Torque and work were measured by isokinetic dynamometry in 13 non-hypoxaemic patients with moderate-to-severe COPD [SpO
2
= 94.1 ± 1.6 %; FEV
1
(% predict) 48.0 ± 9.6; GOLD II–III] and 13 age- and sex-matched sedentary controls.
Results
There was no desaturation in either group during NMES. Torque and work were reduced in COPD versus control for 40 and 50 mA [torque (Nm) 50 mA = 28.9 ± 6.9 vs 46.1 ± 14.2; work (J) 50 mA = 437.2 ± 130.0 vs. 608.3 ± 136.8;
P
< 0.05 for all]. High µO
2
EF values were observed in the COPD group at both NMES intensities (corrected by muscle mass 50 mA = 6.18 ± 1.1 vs. 4.68 ± 1.0 %/kg; corrected by work 50 mA = 0.12 ± 0.05 vs. 0.07 ± 0.02 %/J;
P
< 0.05 for all). Absolute values of HHb-τ (50 mA = 31.11 ± 9.27 vs. 18.08 ± 10.70 s), corrected for muscle mass (50 mA 3.80 ± 1.28 vs. 2.05 ± 1.45 s/kg) and corrected for work (50 mA = 0.08 ± 0.04 vs. 0.03 ± 0.02 s/J) were reduced in COPD (
P
< 0.05 for all). The variables behaviour for 40 mA was similar to those of 50 mA.
Conclusions
COPD patients exhibited a slower muscle deoxygenation recovery time after NMES. The absence of desaturation, low torque and work, high µO
2
EF and high values for recovery time corrected by muscle mass and work suggest that intrinsic muscle dysfunction has an impact on muscle recovery capacity.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-016-3442-7</identifier><identifier>PMID: 27468840</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenosine diphosphate ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Chronic obstructive pulmonary disease ; Exercise ; Female ; Hemoglobin ; Hemoglobins - metabolism ; Human Physiology ; Humans ; Kinetics ; Male ; Metabolic Clearance Rate ; Metabolism ; Middle Aged ; Muscle recovery ; Muscle Strength ; Muscle, Skeletal - physiopathology ; Muscular Atrophy - etiology ; Muscular Atrophy - physiopathology ; Muscular Atrophy - therapy ; Musculoskeletal system ; Neuromuscular electrical stimulation ; Occupational Medicine/Industrial Medicine ; Original Article ; Oxygen - metabolism ; Oxygen Consumption ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Disease, Chronic Obstructive - therapy ; Spectrum analysis ; Sports Medicine ; Transcutaneous Electric Nerve Stimulation - methods ; Treatment Outcome</subject><ispartof>European journal of applied physiology, 2016-10, Vol.116 (10), p.1899-1910</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-37d6c764b463dc1253e8f446d965866d851a4bde57090b0624200d9e9e694c7a3</citedby><cites>FETCH-LOGICAL-c471t-37d6c764b463dc1253e8f446d965866d851a4bde57090b0624200d9e9e694c7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-016-3442-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-016-3442-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27468840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azevedo, Diego de Paiva</creatorcontrib><creatorcontrib>Medeiros, Wladimir Musetti</creatorcontrib><creatorcontrib>de Freitas, Flávia Fernandes Manfredi</creatorcontrib><creatorcontrib>Ferreira Amorim, Cesar</creatorcontrib><creatorcontrib>Gimenes, Ana Cristina Oliveira</creatorcontrib><creatorcontrib>Neder, Jose Alberto</creatorcontrib><creatorcontrib>Chiavegato, Luciana Dias</creatorcontrib><title>High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Purpose
It was hypothesized that patients with chronic obstructive pulmonary disease (COPD) would exhibit a slow muscle deoxygenation (HHb) recovery time when compared with sedentary controls.
Methods
Neuromuscular electrical stimulation (NMES 40 and 50 mA, 50 Hz, 400 µs) was employed to induce isometric contraction of the quadriceps. Microvascular oxygen extraction (µO
2
EF) and HHb were estimated by near-infrared spectroscopy (NIRS). Recovery kinetic was characterized by measuring the time constant Tau (HHb-τ). Torque and work were measured by isokinetic dynamometry in 13 non-hypoxaemic patients with moderate-to-severe COPD [SpO
2
= 94.1 ± 1.6 %; FEV
1
(% predict) 48.0 ± 9.6; GOLD II–III] and 13 age- and sex-matched sedentary controls.
Results
There was no desaturation in either group during NMES. Torque and work were reduced in COPD versus control for 40 and 50 mA [torque (Nm) 50 mA = 28.9 ± 6.9 vs 46.1 ± 14.2; work (J) 50 mA = 437.2 ± 130.0 vs. 608.3 ± 136.8;
P
< 0.05 for all]. High µO
2
EF values were observed in the COPD group at both NMES intensities (corrected by muscle mass 50 mA = 6.18 ± 1.1 vs. 4.68 ± 1.0 %/kg; corrected by work 50 mA = 0.12 ± 0.05 vs. 0.07 ± 0.02 %/J;
P
< 0.05 for all). Absolute values of HHb-τ (50 mA = 31.11 ± 9.27 vs. 18.08 ± 10.70 s), corrected for muscle mass (50 mA 3.80 ± 1.28 vs. 2.05 ± 1.45 s/kg) and corrected for work (50 mA = 0.08 ± 0.04 vs. 0.03 ± 0.02 s/J) were reduced in COPD (
P
< 0.05 for all). The variables behaviour for 40 mA was similar to those of 50 mA.
Conclusions
COPD patients exhibited a slower muscle deoxygenation recovery time after NMES. The absence of desaturation, low torque and work, high µO
2
EF and high values for recovery time corrected by muscle mass and work suggest that intrinsic muscle dysfunction has an impact on muscle recovery capacity.</description><subject>Adenosine diphosphate</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Exercise</subject><subject>Female</subject><subject>Hemoglobin</subject><subject>Hemoglobins - metabolism</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Metabolic Clearance Rate</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Muscle recovery</subject><subject>Muscle Strength</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscular Atrophy - etiology</subject><subject>Muscular Atrophy - physiopathology</subject><subject>Muscular Atrophy - therapy</subject><subject>Musculoskeletal system</subject><subject>Neuromuscular electrical stimulation</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Oxygen - metabolism</subject><subject>Oxygen Consumption</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary Disease, Chronic Obstructive - therapy</subject><subject>Spectrum analysis</subject><subject>Sports Medicine</subject><subject>Transcutaneous Electric Nerve Stimulation - methods</subject><subject>Treatment Outcome</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkctu1DAUhiNERUvhAdggS2zYBHyLL0s0FIpUqV3A2vLYJ4NLYg-2QzsPwHuTNKVCSEisfPv-_8j6muYFwW8IxvJtwZhT0mIiWsY5beWj5oRwplvBqHz8sCf6uHlayjXGWFGinjTHVHKhFMcnzc_zsPuK0u1hBxHBbc3W1ZAistGjMqQblMGlH5APKPVonIobAHlYeXtHfgsRanAF2b5CRhGmnBZwGmxGMICrOTg7oFLDON_dZUJEm8ur92g_HyHW8qw56u1Q4Pn9etp8-XD2eXPeXlx-_LR5d9E6LkltmfTCScG3XDDvCO0YqJ5z4bXolBBedcTyrYdOYo23WFBOMfYaNAjNnbTstHm99u5z-j5BqWYMxcEw2AhpKoYoKjXrMFf_gRLNGcOazuirv9DrNOU4f2ShVKeFFEshWSmXUykZerPPYbT5YAg2i06z6jSzTrPoNHLOvLxvnrYj-IfEb38zQFegzE9xB_mP0f9s_QU-mKuN</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Azevedo, Diego de Paiva</creator><creator>Medeiros, Wladimir Musetti</creator><creator>de Freitas, Flávia Fernandes Manfredi</creator><creator>Ferreira Amorim, Cesar</creator><creator>Gimenes, Ana Cristina Oliveira</creator><creator>Neder, Jose Alberto</creator><creator>Chiavegato, Luciana Dias</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>20161001</creationdate><title>High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients</title><author>Azevedo, Diego de Paiva ; Medeiros, Wladimir Musetti ; de Freitas, Flávia Fernandes Manfredi ; Ferreira Amorim, Cesar ; Gimenes, Ana Cristina Oliveira ; Neder, Jose Alberto ; Chiavegato, Luciana Dias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-37d6c764b463dc1253e8f446d965866d851a4bde57090b0624200d9e9e694c7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenosine diphosphate</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Exercise</topic><topic>Female</topic><topic>Hemoglobin</topic><topic>Hemoglobins - metabolism</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Metabolic Clearance Rate</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Muscle recovery</topic><topic>Muscle Strength</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscular Atrophy - etiology</topic><topic>Muscular Atrophy - physiopathology</topic><topic>Muscular Atrophy - therapy</topic><topic>Musculoskeletal system</topic><topic>Neuromuscular electrical stimulation</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Oxygen - metabolism</topic><topic>Oxygen Consumption</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary Disease, Chronic Obstructive - therapy</topic><topic>Spectrum analysis</topic><topic>Sports Medicine</topic><topic>Transcutaneous Electric Nerve Stimulation - methods</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azevedo, Diego de Paiva</creatorcontrib><creatorcontrib>Medeiros, Wladimir Musetti</creatorcontrib><creatorcontrib>de Freitas, Flávia Fernandes Manfredi</creatorcontrib><creatorcontrib>Ferreira Amorim, Cesar</creatorcontrib><creatorcontrib>Gimenes, Ana Cristina Oliveira</creatorcontrib><creatorcontrib>Neder, Jose Alberto</creatorcontrib><creatorcontrib>Chiavegato, Luciana Dias</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azevedo, Diego de Paiva</au><au>Medeiros, Wladimir Musetti</au><au>de Freitas, Flávia Fernandes Manfredi</au><au>Ferreira Amorim, Cesar</au><au>Gimenes, Ana Cristina Oliveira</au><au>Neder, Jose Alberto</au><au>Chiavegato, Luciana Dias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>116</volume><issue>10</issue><spage>1899</spage><epage>1910</epage><pages>1899-1910</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Purpose
It was hypothesized that patients with chronic obstructive pulmonary disease (COPD) would exhibit a slow muscle deoxygenation (HHb) recovery time when compared with sedentary controls.
Methods
Neuromuscular electrical stimulation (NMES 40 and 50 mA, 50 Hz, 400 µs) was employed to induce isometric contraction of the quadriceps. Microvascular oxygen extraction (µO
2
EF) and HHb were estimated by near-infrared spectroscopy (NIRS). Recovery kinetic was characterized by measuring the time constant Tau (HHb-τ). Torque and work were measured by isokinetic dynamometry in 13 non-hypoxaemic patients with moderate-to-severe COPD [SpO
2
= 94.1 ± 1.6 %; FEV
1
(% predict) 48.0 ± 9.6; GOLD II–III] and 13 age- and sex-matched sedentary controls.
Results
There was no desaturation in either group during NMES. Torque and work were reduced in COPD versus control for 40 and 50 mA [torque (Nm) 50 mA = 28.9 ± 6.9 vs 46.1 ± 14.2; work (J) 50 mA = 437.2 ± 130.0 vs. 608.3 ± 136.8;
P
< 0.05 for all]. High µO
2
EF values were observed in the COPD group at both NMES intensities (corrected by muscle mass 50 mA = 6.18 ± 1.1 vs. 4.68 ± 1.0 %/kg; corrected by work 50 mA = 0.12 ± 0.05 vs. 0.07 ± 0.02 %/J;
P
< 0.05 for all). Absolute values of HHb-τ (50 mA = 31.11 ± 9.27 vs. 18.08 ± 10.70 s), corrected for muscle mass (50 mA 3.80 ± 1.28 vs. 2.05 ± 1.45 s/kg) and corrected for work (50 mA = 0.08 ± 0.04 vs. 0.03 ± 0.02 s/J) were reduced in COPD (
P
< 0.05 for all). The variables behaviour for 40 mA was similar to those of 50 mA.
Conclusions
COPD patients exhibited a slower muscle deoxygenation recovery time after NMES. The absence of desaturation, low torque and work, high µO
2
EF and high values for recovery time corrected by muscle mass and work suggest that intrinsic muscle dysfunction has an impact on muscle recovery capacity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27468840</pmid><doi>10.1007/s00421-016-3442-7</doi><tpages>12</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adenosine diphosphate Biomedical and Life Sciences Biomedicine Blood Chronic obstructive pulmonary disease Exercise Female Hemoglobin Hemoglobins - metabolism Human Physiology Humans Kinetics Male Metabolic Clearance Rate Metabolism Middle Aged Muscle recovery Muscle Strength Muscle, Skeletal - physiopathology Muscular Atrophy - etiology Muscular Atrophy - physiopathology Muscular Atrophy - therapy Musculoskeletal system Neuromuscular electrical stimulation Occupational Medicine/Industrial Medicine Original Article Oxygen - metabolism Oxygen Consumption Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Disease, Chronic Obstructive - therapy Spectrum analysis Sports Medicine Transcutaneous Electric Nerve Stimulation - methods Treatment Outcome |
| title | High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients |
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