Impact of optical coherence tomography- and coronary angioscopy-assessed neointimal tissue characteristics on occurrence of periprocedural myonecrosis in patients with in-stent restenosis
Several characteristics of neointimal tissues, including neoatherosclerotic progression, have been reported in lesions with in-stent restenosis (ISR). However, the effects of these characteristics on outcomes after percutaneous coronary intervention (PCI) for ISR lesions remain unclear. We assessed...
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| Veröffentlicht in: | International Journal of Cardiovascular Imaging 2016-10, Vol.32 (10), p.1483-1494 |
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| creator | Kimura, Shigeki Sugiyama, Tomoyo Hishikari, Keiichi Nakamura, Shun Nakagama, Shun Misawa, Toru Mizusawa, Masafumi Hayasaka, Kazuto Yamakami, Yosuke Sagawa, Yuichiro Kojima, Keisuke Ohtani, Hirofumi Hikita, Hiroyuki Takahashi, Atsushi Isobe, Mitsuaki |
| description | Several characteristics of neointimal tissues, including neoatherosclerotic progression, have been reported in lesions with in-stent restenosis (ISR). However, the effects of these characteristics on outcomes after percutaneous coronary intervention (PCI) for ISR lesions remain unclear. We assessed the relationships between neointimal tissue characteristics and the occurrence of periprocedural myonecrosis (PMN) after PCI in ISR lesions. We investigated 72 ISR lesions in 72 patients with stable angina pectoris (SAP) who underwent pre- and post-revascularization optical coherence tomography (OCT) and coronary angioscopy (CAS). All lesions were classified as with PMN, defined by an elevated peak high-sensitivity cardiac troponin-T level during the 24-h post-PCI period, and without PMN. PMN was observed in 23 (31.9 %) lesions. PMN lesions had higher frequencies of OCT-derived thin-cap fibroatheroma (26.1 vs. 6.1 %, P = 0.03), CAS-derived intensive yellow neointima (30.4 vs. 10.2 %, P = 0.04), neointima with complex surface (60.9 vs. 28.6 %, P = 0.01), and CAS-derived atheromatous appearance (CAS-AAP), defined as yellow plaque including complex thrombi underneath disrupted neointimal coverage after ballooning (47.8 vs. 16.3 %, P = 0.008) at the most stenotic sites inside stents, compared to lesions without PMN. Multivariate logistic regression analysis identified CAS-AAP (odds ratio: 3.568, 95 % confidence interval: 1.109–11.475, P = 0.033) as an independent predictor of PMN. For ISR lesions in SAP patients, an OCT- and CAS-based assessment of neointimal tissue characteristics might help to predict the occurrence of PMN. |
| doi_str_mv | 10.1007/s10554-016-0941-x |
| format | Article |
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However, the effects of these characteristics on outcomes after percutaneous coronary intervention (PCI) for ISR lesions remain unclear. We assessed the relationships between neointimal tissue characteristics and the occurrence of periprocedural myonecrosis (PMN) after PCI in ISR lesions. We investigated 72 ISR lesions in 72 patients with stable angina pectoris (SAP) who underwent pre- and post-revascularization optical coherence tomography (OCT) and coronary angioscopy (CAS). All lesions were classified as with PMN, defined by an elevated peak high-sensitivity cardiac troponin-T level during the 24-h post-PCI period, and without PMN. PMN was observed in 23 (31.9 %) lesions. PMN lesions had higher frequencies of OCT-derived thin-cap fibroatheroma (26.1 vs. 6.1 %, P = 0.03), CAS-derived intensive yellow neointima (30.4 vs. 10.2 %, P = 0.04), neointima with complex surface (60.9 vs. 28.6 %, P = 0.01), and CAS-derived atheromatous appearance (CAS-AAP), defined as yellow plaque including complex thrombi underneath disrupted neointimal coverage after ballooning (47.8 vs. 16.3 %, P = 0.008) at the most stenotic sites inside stents, compared to lesions without PMN. Multivariate logistic regression analysis identified CAS-AAP (odds ratio: 3.568, 95 % confidence interval: 1.109–11.475, P = 0.033) as an independent predictor of PMN. For ISR lesions in SAP patients, an OCT- and CAS-based assessment of neointimal tissue characteristics might help to predict the occurrence of PMN.</description><identifier>ISSN: 1569-5794</identifier><identifier>EISSN: 1573-0743</identifier><identifier>EISSN: 1875-8312</identifier><identifier>DOI: 10.1007/s10554-016-0941-x</identifier><identifier>PMID: 27423209</identifier><identifier>CODEN: IJCIBI</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aged ; Aged, 80 and over ; Angioscopy ; Biomarkers - blood ; Cardiac Imaging ; Cardiology ; Coronary Angiography ; Coronary Restenosis - diagnostic imaging ; Coronary Restenosis - pathology ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - pathology ; Female ; Humans ; Imaging ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Myocardium - metabolism ; Myocardium - pathology ; Necrosis ; Neointima ; Observer Variation ; Odds Ratio ; Original Paper ; Percutaneous Coronary Intervention - adverse effects ; Percutaneous Coronary Intervention - instrumentation ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Radiology ; Reproducibility of Results ; Retrospective Studies ; Risk Factors ; Stents ; Time Factors ; Tokyo ; Tomography, Optical Coherence ; Troponin - blood</subject><ispartof>International Journal of Cardiovascular Imaging, 2016-10, Vol.32 (10), p.1483-1494</ispartof><rights>Springer Science+Business Media Dordrecht 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-44513727feaaa8f53636e555986a290ee4d7d4549960d20ca5c3c3aa45afd8453</citedby><cites>FETCH-LOGICAL-c405t-44513727feaaa8f53636e555986a290ee4d7d4549960d20ca5c3c3aa45afd8453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10554-016-0941-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10554-016-0941-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27423209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kimura, Shigeki</creatorcontrib><creatorcontrib>Sugiyama, Tomoyo</creatorcontrib><creatorcontrib>Hishikari, Keiichi</creatorcontrib><creatorcontrib>Nakamura, Shun</creatorcontrib><creatorcontrib>Nakagama, Shun</creatorcontrib><creatorcontrib>Misawa, Toru</creatorcontrib><creatorcontrib>Mizusawa, Masafumi</creatorcontrib><creatorcontrib>Hayasaka, Kazuto</creatorcontrib><creatorcontrib>Yamakami, Yosuke</creatorcontrib><creatorcontrib>Sagawa, Yuichiro</creatorcontrib><creatorcontrib>Kojima, Keisuke</creatorcontrib><creatorcontrib>Ohtani, Hirofumi</creatorcontrib><creatorcontrib>Hikita, Hiroyuki</creatorcontrib><creatorcontrib>Takahashi, Atsushi</creatorcontrib><creatorcontrib>Isobe, Mitsuaki</creatorcontrib><title>Impact of optical coherence tomography- and coronary angioscopy-assessed neointimal tissue characteristics on occurrence of periprocedural myonecrosis in patients with in-stent restenosis</title><title>International Journal of Cardiovascular Imaging</title><addtitle>Int J Cardiovasc Imaging</addtitle><addtitle>Int J Cardiovasc Imaging</addtitle><description>Several characteristics of neointimal tissues, including neoatherosclerotic progression, have been reported in lesions with in-stent restenosis (ISR). However, the effects of these characteristics on outcomes after percutaneous coronary intervention (PCI) for ISR lesions remain unclear. We assessed the relationships between neointimal tissue characteristics and the occurrence of periprocedural myonecrosis (PMN) after PCI in ISR lesions. We investigated 72 ISR lesions in 72 patients with stable angina pectoris (SAP) who underwent pre- and post-revascularization optical coherence tomography (OCT) and coronary angioscopy (CAS). All lesions were classified as with PMN, defined by an elevated peak high-sensitivity cardiac troponin-T level during the 24-h post-PCI period, and without PMN. PMN was observed in 23 (31.9 %) lesions. PMN lesions had higher frequencies of OCT-derived thin-cap fibroatheroma (26.1 vs. 6.1 %, P = 0.03), CAS-derived intensive yellow neointima (30.4 vs. 10.2 %, P = 0.04), neointima with complex surface (60.9 vs. 28.6 %, P = 0.01), and CAS-derived atheromatous appearance (CAS-AAP), defined as yellow plaque including complex thrombi underneath disrupted neointimal coverage after ballooning (47.8 vs. 16.3 %, P = 0.008) at the most stenotic sites inside stents, compared to lesions without PMN. Multivariate logistic regression analysis identified CAS-AAP (odds ratio: 3.568, 95 % confidence interval: 1.109–11.475, P = 0.033) as an independent predictor of PMN. For ISR lesions in SAP patients, an OCT- and CAS-based assessment of neointimal tissue characteristics might help to predict the occurrence of PMN.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angioscopy</subject><subject>Biomarkers - blood</subject><subject>Cardiac Imaging</subject><subject>Cardiology</subject><subject>Coronary Angiography</subject><subject>Coronary Restenosis - diagnostic imaging</subject><subject>Coronary Restenosis - pathology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Necrosis</subject><subject>Neointima</subject><subject>Observer Variation</subject><subject>Odds Ratio</subject><subject>Original Paper</subject><subject>Percutaneous Coronary Intervention - adverse effects</subject><subject>Percutaneous Coronary Intervention - instrumentation</subject><subject>Plaque, Atherosclerotic</subject><subject>Predictive Value of Tests</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stents</subject><subject>Time Factors</subject><subject>Tokyo</subject><subject>Tomography, Optical Coherence</subject><subject>Troponin - blood</subject><issn>1569-5794</issn><issn>1573-0743</issn><issn>1875-8312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNks2KFDEQxxtR3HX1AbxIwIuXaOWre3KUZdWFBS96bmK6eibLdNImadx-Nl_OamcVEQQhkFTqV_9KVappngt4LQC6N0WAMZqDaDlYLfjdg-ZcmE5x6LR6uJ1by01n9VnzpJRbAJAg1ePmTHZaKgn2vPl-Pc3OV5ZGluYavDsynw6YMXpkNU1pn918WDlzcSBPTtHllYx9SMWneeWuFKQ1sIgpxBomUqihlAWZP7hM2phDIeXCUmTJ-yWfxCnjTK45J4_DkilsWlNEn1MJhYXIZlcDxlrYt1APdMFLJZNl3PYNeto8Gt2x4LP7_aL5_O7q0-UHfvPx_fXl2xvuNZjKtTZCdbIb0Tm3G41qVYvGGLtrnbSAqIdu0EZb28IgwTvjlVfOaePGYaeNumhenXTprV8XSt9PoXg8Hh3VvJRe7GRnlbLG_gcqrAVQShD68i_0Ni05UiE_KaAXgyZKnKitLyXj2M-ZepzXXkC_DUF_GoKehqDfhqC_o5gX98rLlwmH3xG_fp0AeQIKueIe8x-p_6n6AzQ3wkQ</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Kimura, Shigeki</creator><creator>Sugiyama, Tomoyo</creator><creator>Hishikari, Keiichi</creator><creator>Nakamura, Shun</creator><creator>Nakagama, Shun</creator><creator>Misawa, Toru</creator><creator>Mizusawa, Masafumi</creator><creator>Hayasaka, Kazuto</creator><creator>Yamakami, Yosuke</creator><creator>Sagawa, Yuichiro</creator><creator>Kojima, Keisuke</creator><creator>Ohtani, Hirofumi</creator><creator>Hikita, Hiroyuki</creator><creator>Takahashi, Atsushi</creator><creator>Isobe, Mitsuaki</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20161001</creationdate><title>Impact of optical coherence tomography- and coronary angioscopy-assessed neointimal tissue characteristics on occurrence of periprocedural myonecrosis in patients with in-stent restenosis</title><author>Kimura, Shigeki ; Sugiyama, Tomoyo ; Hishikari, Keiichi ; Nakamura, Shun ; Nakagama, Shun ; Misawa, Toru ; Mizusawa, Masafumi ; Hayasaka, Kazuto ; Yamakami, Yosuke ; Sagawa, Yuichiro ; Kojima, Keisuke ; Ohtani, Hirofumi ; Hikita, Hiroyuki ; Takahashi, Atsushi ; Isobe, Mitsuaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-44513727feaaa8f53636e555986a290ee4d7d4549960d20ca5c3c3aa45afd8453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angioscopy</topic><topic>Biomarkers - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>International Journal of Cardiovascular Imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimura, Shigeki</au><au>Sugiyama, Tomoyo</au><au>Hishikari, Keiichi</au><au>Nakamura, Shun</au><au>Nakagama, Shun</au><au>Misawa, Toru</au><au>Mizusawa, Masafumi</au><au>Hayasaka, Kazuto</au><au>Yamakami, Yosuke</au><au>Sagawa, Yuichiro</au><au>Kojima, Keisuke</au><au>Ohtani, Hirofumi</au><au>Hikita, Hiroyuki</au><au>Takahashi, Atsushi</au><au>Isobe, Mitsuaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of optical coherence tomography- and coronary angioscopy-assessed neointimal tissue characteristics on occurrence of periprocedural myonecrosis in patients with in-stent restenosis</atitle><jtitle>International Journal of Cardiovascular Imaging</jtitle><stitle>Int J Cardiovasc Imaging</stitle><addtitle>Int J Cardiovasc Imaging</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>32</volume><issue>10</issue><spage>1483</spage><epage>1494</epage><pages>1483-1494</pages><issn>1569-5794</issn><eissn>1573-0743</eissn><eissn>1875-8312</eissn><coden>IJCIBI</coden><abstract>Several characteristics of neointimal tissues, including neoatherosclerotic progression, have been reported in lesions with in-stent restenosis (ISR). However, the effects of these characteristics on outcomes after percutaneous coronary intervention (PCI) for ISR lesions remain unclear. We assessed the relationships between neointimal tissue characteristics and the occurrence of periprocedural myonecrosis (PMN) after PCI in ISR lesions. We investigated 72 ISR lesions in 72 patients with stable angina pectoris (SAP) who underwent pre- and post-revascularization optical coherence tomography (OCT) and coronary angioscopy (CAS). All lesions were classified as with PMN, defined by an elevated peak high-sensitivity cardiac troponin-T level during the 24-h post-PCI period, and without PMN. PMN was observed in 23 (31.9 %) lesions. PMN lesions had higher frequencies of OCT-derived thin-cap fibroatheroma (26.1 vs. 6.1 %, P = 0.03), CAS-derived intensive yellow neointima (30.4 vs. 10.2 %, P = 0.04), neointima with complex surface (60.9 vs. 28.6 %, P = 0.01), and CAS-derived atheromatous appearance (CAS-AAP), defined as yellow plaque including complex thrombi underneath disrupted neointimal coverage after ballooning (47.8 vs. 16.3 %, P = 0.008) at the most stenotic sites inside stents, compared to lesions without PMN. Multivariate logistic regression analysis identified CAS-AAP (odds ratio: 3.568, 95 % confidence interval: 1.109–11.475, P = 0.033) as an independent predictor of PMN. For ISR lesions in SAP patients, an OCT- and CAS-based assessment of neointimal tissue characteristics might help to predict the occurrence of PMN.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>27423209</pmid><doi>10.1007/s10554-016-0941-x</doi><tpages>12</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Angioscopy Biomarkers - blood Cardiac Imaging Cardiology Coronary Angiography Coronary Restenosis - diagnostic imaging Coronary Restenosis - pathology Coronary Vessels - diagnostic imaging Coronary Vessels - pathology Female Humans Imaging Logistic Models Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Myocardium - metabolism Myocardium - pathology Necrosis Neointima Observer Variation Odds Ratio Original Paper Percutaneous Coronary Intervention - adverse effects Percutaneous Coronary Intervention - instrumentation Plaque, Atherosclerotic Predictive Value of Tests Radiology Reproducibility of Results Retrospective Studies Risk Factors Stents Time Factors Tokyo Tomography, Optical Coherence Troponin - blood |
| title | Impact of optical coherence tomography- and coronary angioscopy-assessed neointimal tissue characteristics on occurrence of periprocedural myonecrosis in patients with in-stent restenosis |
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