Ready to clone: CNV detection and breakpoint fine-mapping in breast and ovarian cancer susceptibility genes by high-resolution array CGH

Purpose Detection of predisposing copy number variants (CNV) in 330 families affected with hereditary breast and ovarian cancer (HBOC). Methods In order to complement mutation detection with Illumina’s TruSight Cancer panel, we designed a customized high-resolution 8 × 60k array for CGH (aCGH) that...

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Veröffentlicht in:	Breast cancer research and treatment 2016-10, Vol.159 (3), p.585-590
Hauptverfasser:	Hackmann, Karl, Kuhlee, Franziska, Betcheva-Krajcir, Elitza, Kahlert, Anne-Karin, Mackenroth, Luisa, Klink, Barbara, Di Donato, Nataliya, Tzschach, Andreas, Kast, Karin, Wimberger, Pauline, Schrock, Evelin, Rump, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Breast cancer Breast Neoplasms - genetics Brief Report Cancer Cancer research Chromosome Breakpoints Chromosome Mapping Cloning Comparative Genomic Hybridization - methods Cytogenetics Disease susceptibility DNA Copy Number Variations Female Genes Genetic aspects Genetic Predisposition to Disease Germ-Line Mutation High-Throughput Nucleotide Sequencing Humans Medicine Medicine & Public Health Oncology Ovarian cancer Ovarian Neoplasms - genetics Sequence Analysis, DNA
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