Differential somatostatin and CXCR4 chemokine receptor expression in MALT-type lymphoma of gastric and extragastric origin
Purpose Whereas the different somatostatin receptor (SSTR) subtypes and the chemokine receptor CXCR4 are known to be expressed in a wide variety of human malignancies, comprehensive data are still lacking for MALT-type lymphomas. Methods Overall, 55 cases of MALT-type lymphoma of both gastric and ex...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2016-11, Vol.142 (11), p.2239-2247 |
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| creator | Stollberg, Susann Kämmerer, Daniel Neubauer, Elisa Schulz, Stefan Simonitsch-Klupp, Ingrid Kiesewetter, Barbara Raderer, Markus Lupp, Amelie |
| description | Purpose
Whereas the different somatostatin receptor (SSTR) subtypes and the chemokine receptor CXCR4 are known to be expressed in a wide variety of human malignancies, comprehensive data are still lacking for MALT-type lymphomas.
Methods
Overall, 55 cases of MALT-type lymphoma of both gastric and extragastric origin were evaluated for the SSTR subtype and CXCR4 expression by means of immunohistochemistry using novel monoclonal rabbit antibodies. The stainings were rated by means of the immunoreactive score and correlated with clinical data.
Results
While the CXCR4 was detected in 92 % of the cases investigated, the SSTR subtypes were much less frequently present. The SSTR5 was expressed in about 50 % of the cases, followed by the SSTR3, the SSTR2A, the SSTR4 and the SSTR1, which were present in 35, 27, 18 or 2 %, respectively, of the tumors only. Gastric lymphomas displayed a significantly higher SSTR3, SSTR4 and SSTR5 expression than extragastric tumors. A correlation between CXCR4 and Ki-67 expression was seen in gastric lymphomas, whereas primarily in extragastric tumors SSTR5 negativity was associated with poor patient outcome.
Conclusions
The CXCR4 may serve as a promising target for diagnostics and therapy of MALT-type lymphomas, while the SSTRs appear not suitable in this respect. |
| doi_str_mv | 10.1007/s00432-016-2220-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1827931961</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4199078151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-c021714f396d8e614ecd55c058f28d866e184c6ed00878be17cebe7f564c33063</originalsourceid><addsrcrecordid>eNp1kU1rGzEQhkVoSdykPyCXIMill231vfIxOP0Cl0JJoDcha2cdpbvSRpIh7q-vtk5KKfQkNPPonREPQueUvKWEtO8yIYKzhlDVMMZIo47Qgs4Vyrl8gRaEtrSRjKoT9Crne1LvsmXH6IS1Ugiulwv089r3PSQIxdsB5zjaEnOxxQdsQ4dX31ffBHZ3MMYfPgBO4GAqMWF4nBLk7GPAFf1ytb5pyn4CPOzH6a6m4Njjrc0lefc7CB5Lss-FmPzWhzP0srdDhtdP5ym6_fD-ZvWpWX_9-Hl1tW6cILI0jrD6DdHzpeo0KCrAdVI6InXPdKeVAqqFU9ARolu9Ado62EDbSyUc50TxU_TmkDul-LCDXMzos4NhsAHiLhuqWbvkdKloRS__Qe_jLoW63UwJUacRWSl6oFyKOSfozZT8aNPeUGJmMeYgxlQxZhZj5iUunpJ3mxG6Py-eTVSAHYBcW2EL6a_R_039BYL7mOU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1824486605</pqid></control><display><type>article</type><title>Differential somatostatin and CXCR4 chemokine receptor expression in MALT-type lymphoma of gastric and extragastric origin</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Stollberg, Susann ; Kämmerer, Daniel ; Neubauer, Elisa ; Schulz, Stefan ; Simonitsch-Klupp, Ingrid ; Kiesewetter, Barbara ; Raderer, Markus ; Lupp, Amelie</creator><creatorcontrib>Stollberg, Susann ; Kämmerer, Daniel ; Neubauer, Elisa ; Schulz, Stefan ; Simonitsch-Klupp, Ingrid ; Kiesewetter, Barbara ; Raderer, Markus ; Lupp, Amelie</creatorcontrib><description>Purpose
Whereas the different somatostatin receptor (SSTR) subtypes and the chemokine receptor CXCR4 are known to be expressed in a wide variety of human malignancies, comprehensive data are still lacking for MALT-type lymphomas.
Methods
Overall, 55 cases of MALT-type lymphoma of both gastric and extragastric origin were evaluated for the SSTR subtype and CXCR4 expression by means of immunohistochemistry using novel monoclonal rabbit antibodies. The stainings were rated by means of the immunoreactive score and correlated with clinical data.
Results
While the CXCR4 was detected in 92 % of the cases investigated, the SSTR subtypes were much less frequently present. The SSTR5 was expressed in about 50 % of the cases, followed by the SSTR3, the SSTR2A, the SSTR4 and the SSTR1, which were present in 35, 27, 18 or 2 %, respectively, of the tumors only. Gastric lymphomas displayed a significantly higher SSTR3, SSTR4 and SSTR5 expression than extragastric tumors. A correlation between CXCR4 and Ki-67 expression was seen in gastric lymphomas, whereas primarily in extragastric tumors SSTR5 negativity was associated with poor patient outcome.
Conclusions
The CXCR4 may serve as a promising target for diagnostics and therapy of MALT-type lymphomas, while the SSTRs appear not suitable in this respect.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-016-2220-6</identifier><identifier>PMID: 27544389</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Amino Acid Sequence ; Autoimmune Diseases - metabolism ; Cancer Research ; Chemokines ; Female ; Helicobacter Infections - metabolism ; Helicobacter pylori - isolation & purification ; Hematology ; Humans ; Immunohistochemistry ; Internal Medicine ; Lymphoma ; Lymphoma, B-Cell, Marginal Zone - immunology ; Lymphoma, B-Cell, Marginal Zone - metabolism ; Lymphoma, B-Cell, Marginal Zone - microbiology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Article – Cancer Research ; Protein expression ; Receptors, CXCR4 - biosynthesis ; Receptors, Somatostatin - biosynthesis ; Somatostatin - biosynthesis ; Stomach Neoplasms - immunology ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - microbiology</subject><ispartof>Journal of cancer research and clinical oncology, 2016-11, Vol.142 (11), p.2239-2247</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-c021714f396d8e614ecd55c058f28d866e184c6ed00878be17cebe7f564c33063</citedby><cites>FETCH-LOGICAL-c405t-c021714f396d8e614ecd55c058f28d866e184c6ed00878be17cebe7f564c33063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-016-2220-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-016-2220-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27544389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stollberg, Susann</creatorcontrib><creatorcontrib>Kämmerer, Daniel</creatorcontrib><creatorcontrib>Neubauer, Elisa</creatorcontrib><creatorcontrib>Schulz, Stefan</creatorcontrib><creatorcontrib>Simonitsch-Klupp, Ingrid</creatorcontrib><creatorcontrib>Kiesewetter, Barbara</creatorcontrib><creatorcontrib>Raderer, Markus</creatorcontrib><creatorcontrib>Lupp, Amelie</creatorcontrib><title>Differential somatostatin and CXCR4 chemokine receptor expression in MALT-type lymphoma of gastric and extragastric origin</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
Whereas the different somatostatin receptor (SSTR) subtypes and the chemokine receptor CXCR4 are known to be expressed in a wide variety of human malignancies, comprehensive data are still lacking for MALT-type lymphomas.
Methods
Overall, 55 cases of MALT-type lymphoma of both gastric and extragastric origin were evaluated for the SSTR subtype and CXCR4 expression by means of immunohistochemistry using novel monoclonal rabbit antibodies. The stainings were rated by means of the immunoreactive score and correlated with clinical data.
Results
While the CXCR4 was detected in 92 % of the cases investigated, the SSTR subtypes were much less frequently present. The SSTR5 was expressed in about 50 % of the cases, followed by the SSTR3, the SSTR2A, the SSTR4 and the SSTR1, which were present in 35, 27, 18 or 2 %, respectively, of the tumors only. Gastric lymphomas displayed a significantly higher SSTR3, SSTR4 and SSTR5 expression than extragastric tumors. A correlation between CXCR4 and Ki-67 expression was seen in gastric lymphomas, whereas primarily in extragastric tumors SSTR5 negativity was associated with poor patient outcome.
Conclusions
The CXCR4 may serve as a promising target for diagnostics and therapy of MALT-type lymphomas, while the SSTRs appear not suitable in this respect.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amino Acid Sequence</subject><subject>Autoimmune Diseases - metabolism</subject><subject>Cancer Research</subject><subject>Chemokines</subject><subject>Female</subject><subject>Helicobacter Infections - metabolism</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Lymphoma</subject><subject>Lymphoma, B-Cell, Marginal Zone - immunology</subject><subject>Lymphoma, B-Cell, Marginal Zone - metabolism</subject><subject>Lymphoma, B-Cell, Marginal Zone - microbiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article – Cancer Research</subject><subject>Protein expression</subject><subject>Receptors, CXCR4 - biosynthesis</subject><subject>Receptors, Somatostatin - biosynthesis</subject><subject>Somatostatin - biosynthesis</subject><subject>Stomach Neoplasms - immunology</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - microbiology</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kU1rGzEQhkVoSdykPyCXIMill231vfIxOP0Cl0JJoDcha2cdpbvSRpIh7q-vtk5KKfQkNPPonREPQueUvKWEtO8yIYKzhlDVMMZIo47Qgs4Vyrl8gRaEtrSRjKoT9Crne1LvsmXH6IS1Ugiulwv089r3PSQIxdsB5zjaEnOxxQdsQ4dX31ffBHZ3MMYfPgBO4GAqMWF4nBLk7GPAFf1ytb5pyn4CPOzH6a6m4Njjrc0lefc7CB5Lss-FmPzWhzP0srdDhtdP5ym6_fD-ZvWpWX_9-Hl1tW6cILI0jrD6DdHzpeo0KCrAdVI6InXPdKeVAqqFU9ARolu9Ado62EDbSyUc50TxU_TmkDul-LCDXMzos4NhsAHiLhuqWbvkdKloRS__Qe_jLoW63UwJUacRWSl6oFyKOSfozZT8aNPeUGJmMeYgxlQxZhZj5iUunpJ3mxG6Py-eTVSAHYBcW2EL6a_R_039BYL7mOU</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Stollberg, Susann</creator><creator>Kämmerer, Daniel</creator><creator>Neubauer, Elisa</creator><creator>Schulz, Stefan</creator><creator>Simonitsch-Klupp, Ingrid</creator><creator>Kiesewetter, Barbara</creator><creator>Raderer, Markus</creator><creator>Lupp, Amelie</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20161101</creationdate><title>Differential somatostatin and CXCR4 chemokine receptor expression in MALT-type lymphoma of gastric and extragastric origin</title><author>Stollberg, Susann ; Kämmerer, Daniel ; Neubauer, Elisa ; Schulz, Stefan ; Simonitsch-Klupp, Ingrid ; Kiesewetter, Barbara ; Raderer, Markus ; Lupp, Amelie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-c021714f396d8e614ecd55c058f28d866e184c6ed00878be17cebe7f564c33063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amino Acid Sequence</topic><topic>Autoimmune Diseases - metabolism</topic><topic>Cancer Research</topic><topic>Chemokines</topic><topic>Female</topic><topic>Helicobacter Infections - metabolism</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Internal Medicine</topic><topic>Lymphoma</topic><topic>Lymphoma, B-Cell, Marginal Zone - immunology</topic><topic>Lymphoma, B-Cell, Marginal Zone - metabolism</topic><topic>Lymphoma, B-Cell, Marginal Zone - microbiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Article – Cancer Research</topic><topic>Protein expression</topic><topic>Receptors, CXCR4 - biosynthesis</topic><topic>Receptors, Somatostatin - biosynthesis</topic><topic>Somatostatin - biosynthesis</topic><topic>Stomach Neoplasms - immunology</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stollberg, Susann</creatorcontrib><creatorcontrib>Kämmerer, Daniel</creatorcontrib><creatorcontrib>Neubauer, Elisa</creatorcontrib><creatorcontrib>Schulz, Stefan</creatorcontrib><creatorcontrib>Simonitsch-Klupp, Ingrid</creatorcontrib><creatorcontrib>Kiesewetter, Barbara</creatorcontrib><creatorcontrib>Raderer, Markus</creatorcontrib><creatorcontrib>Lupp, Amelie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stollberg, Susann</au><au>Kämmerer, Daniel</au><au>Neubauer, Elisa</au><au>Schulz, Stefan</au><au>Simonitsch-Klupp, Ingrid</au><au>Kiesewetter, Barbara</au><au>Raderer, Markus</au><au>Lupp, Amelie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential somatostatin and CXCR4 chemokine receptor expression in MALT-type lymphoma of gastric and extragastric origin</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>142</volume><issue>11</issue><spage>2239</spage><epage>2247</epage><pages>2239-2247</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
Whereas the different somatostatin receptor (SSTR) subtypes and the chemokine receptor CXCR4 are known to be expressed in a wide variety of human malignancies, comprehensive data are still lacking for MALT-type lymphomas.
Methods
Overall, 55 cases of MALT-type lymphoma of both gastric and extragastric origin were evaluated for the SSTR subtype and CXCR4 expression by means of immunohistochemistry using novel monoclonal rabbit antibodies. The stainings were rated by means of the immunoreactive score and correlated with clinical data.
Results
While the CXCR4 was detected in 92 % of the cases investigated, the SSTR subtypes were much less frequently present. The SSTR5 was expressed in about 50 % of the cases, followed by the SSTR3, the SSTR2A, the SSTR4 and the SSTR1, which were present in 35, 27, 18 or 2 %, respectively, of the tumors only. Gastric lymphomas displayed a significantly higher SSTR3, SSTR4 and SSTR5 expression than extragastric tumors. A correlation between CXCR4 and Ki-67 expression was seen in gastric lymphomas, whereas primarily in extragastric tumors SSTR5 negativity was associated with poor patient outcome.
Conclusions
The CXCR4 may serve as a promising target for diagnostics and therapy of MALT-type lymphomas, while the SSTRs appear not suitable in this respect.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27544389</pmid><doi>10.1007/s00432-016-2220-6</doi><tpages>9</tpages></addata></record> |
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| issn | 0171-5216 1432-1335 |
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| subjects | Adult Aged Aged, 80 and over Amino Acid Sequence Autoimmune Diseases - metabolism Cancer Research Chemokines Female Helicobacter Infections - metabolism Helicobacter pylori - isolation & purification Hematology Humans Immunohistochemistry Internal Medicine Lymphoma Lymphoma, B-Cell, Marginal Zone - immunology Lymphoma, B-Cell, Marginal Zone - metabolism Lymphoma, B-Cell, Marginal Zone - microbiology Male Medicine Medicine & Public Health Middle Aged Oncology Original Article – Cancer Research Protein expression Receptors, CXCR4 - biosynthesis Receptors, Somatostatin - biosynthesis Somatostatin - biosynthesis Stomach Neoplasms - immunology Stomach Neoplasms - metabolism Stomach Neoplasms - microbiology |
| title | Differential somatostatin and CXCR4 chemokine receptor expression in MALT-type lymphoma of gastric and extragastric origin |
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