SHh-Gli1 signaling pathway promotes cell survival by mediating baculoviral IAP repeat-containing 3 (BIRC3) gene in pancreatic cancer cells

The abnormally activated hedgehog (Hh) signaling pathway is involved in the regulation of proliferation and apoptosis in pancreatic cancer cells, while its exact molecular mechanism is not clear. The purpose of this study was to investigate the regulatory effect of Hh signaling pathway on the transc...

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Veröffentlicht in:	Tumor biology 2016-07, Vol.37 (7), p.9943-9950
Hauptverfasser:	Gan, Huizhong, Liu, Hua, Zhang, Hui, Li, Yueyue, Xu, Xiaorong, Xu, Xuanfu, Xu, Jianming
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Baculoviral IAP Repeat-Containing 3 Protein Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Cell growth Cell Proliferation Chromatin Immunoprecipitation Gene expression Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Humans Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism Original Article Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Signal Transduction Tumor Cells, Cultured Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Zinc Finger Protein GLI1 - genetics Zinc Finger Protein GLI1 - metabolism
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