Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats
Melatonin is a neuroendocrine hormone that presents a wide range of physiological functions including regulating circadian rhythms and sleep, enhancing immune function, sleep improvement, and antioxidant effects. In addition, melatonin has received special attention in pain treatment since it is eff...
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| Veröffentlicht in: | Inflammation 2016-10, Vol.39 (5), p.1649-1659 |
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| creator | Scarabelot, Vanessa Leal Medeiros, Liciane Fernandes de Oliveira, Carla Adachi, Lauren Naomi Spezia de Macedo, Isabel Cristina Cioato, Stefania Giotti de Freitas, Joice S. de Souza, Andressa Quevedo, Alexandre Caumo, Wolnei Torres, Iraci Lucena da Silva |
| description | Melatonin is a neuroendocrine hormone that presents a wide range of physiological functions including regulating circadian rhythms and sleep, enhancing immune function, sleep improvement, and antioxidant effects. In addition, melatonin has received special attention in pain treatment since it is effective and presents few adverse effects. In this study, we evaluated the effect of acute dose of melatonin upon hyperalgesia induced by complete Freund’s adjuvant in a chronic orofacial pain model in Sprague–Dawley rats. Nociceptive behavior was assessed by facial Von Frey and the hot plate tests at baseline and thereafter 30, 60, and 120 min, 24 h, and 7 days after melatonin treatment. We demonstrated that acute melatonin administration alters mechanical and thermal hyperalgesia induced by an orofacial pain model (TMD), highlighting that the melatonin effect upon mechanical hyperalgesia remained until 7 days after its administration. Besides, we observed specific tissue profiles of neuroimmunomodulators linked to pain conditions and/or melatonin effect (brain-derived neurotrophic factor, nerve growth factor, and interleukins 6 and 10) in the brainstem levels, and its effects were state-dependent of the baseline of these animals. |
| doi_str_mv | 10.1007/s10753-016-0399-y |
| format | Article |
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In addition, melatonin has received special attention in pain treatment since it is effective and presents few adverse effects. In this study, we evaluated the effect of acute dose of melatonin upon hyperalgesia induced by complete Freund’s adjuvant in a chronic orofacial pain model in Sprague–Dawley rats. Nociceptive behavior was assessed by facial Von Frey and the hot plate tests at baseline and thereafter 30, 60, and 120 min, 24 h, and 7 days after melatonin treatment. We demonstrated that acute melatonin administration alters mechanical and thermal hyperalgesia induced by an orofacial pain model (TMD), highlighting that the melatonin effect upon mechanical hyperalgesia remained until 7 days after its administration. Besides, we observed specific tissue profiles of neuroimmunomodulators linked to pain conditions and/or melatonin effect (brain-derived neurotrophic factor, nerve growth factor, and interleukins 6 and 10) in the brainstem levels, and its effects were state-dependent of the baseline of these animals.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-016-0399-y</identifier><identifier>PMID: 27378529</identifier><identifier>CODEN: INFLD4</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Brain Stem - metabolism ; Facial Pain - complications ; Freund's Adjuvant ; Hyperalgesia - chemically induced ; Hyperalgesia - drug therapy ; Immunology ; Internal Medicine ; Melatonin - pharmacology ; Melatonin - therapeutic use ; Neuroimmunomodulation - drug effects ; Original Article ; Pathology ; Pharmacology/Toxicology ; Rats ; Rats, Sprague-Dawley ; Rheumatology</subject><ispartof>Inflammation, 2016-10, Vol.39 (5), p.1649-1659</ispartof><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-65e0024997c9c63523de9ba7d990bb7f12c8675801e2db23cb9b7a353a13f9da3</citedby><cites>FETCH-LOGICAL-c405t-65e0024997c9c63523de9ba7d990bb7f12c8675801e2db23cb9b7a353a13f9da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-016-0399-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-016-0399-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27378529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scarabelot, Vanessa Leal</creatorcontrib><creatorcontrib>Medeiros, Liciane Fernandes</creatorcontrib><creatorcontrib>de Oliveira, Carla</creatorcontrib><creatorcontrib>Adachi, Lauren Naomi Spezia</creatorcontrib><creatorcontrib>de Macedo, Isabel Cristina</creatorcontrib><creatorcontrib>Cioato, Stefania Giotti</creatorcontrib><creatorcontrib>de Freitas, Joice S.</creatorcontrib><creatorcontrib>de Souza, Andressa</creatorcontrib><creatorcontrib>Quevedo, Alexandre</creatorcontrib><creatorcontrib>Caumo, Wolnei</creatorcontrib><creatorcontrib>Torres, Iraci Lucena da Silva</creatorcontrib><title>Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Melatonin is a neuroendocrine hormone that presents a wide range of physiological functions including regulating circadian rhythms and sleep, enhancing immune function, sleep improvement, and antioxidant effects. In addition, melatonin has received special attention in pain treatment since it is effective and presents few adverse effects. In this study, we evaluated the effect of acute dose of melatonin upon hyperalgesia induced by complete Freund’s adjuvant in a chronic orofacial pain model in Sprague–Dawley rats. Nociceptive behavior was assessed by facial Von Frey and the hot plate tests at baseline and thereafter 30, 60, and 120 min, 24 h, and 7 days after melatonin treatment. We demonstrated that acute melatonin administration alters mechanical and thermal hyperalgesia induced by an orofacial pain model (TMD), highlighting that the melatonin effect upon mechanical hyperalgesia remained until 7 days after its administration. Besides, we observed specific tissue profiles of neuroimmunomodulators linked to pain conditions and/or melatonin effect (brain-derived neurotrophic factor, nerve growth factor, and interleukins 6 and 10) in the brainstem levels, and its effects were state-dependent of the baseline of these animals.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Stem - metabolism</subject><subject>Facial Pain - complications</subject><subject>Freund's Adjuvant</subject><subject>Hyperalgesia - chemically induced</subject><subject>Hyperalgesia - drug therapy</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Melatonin - pharmacology</subject><subject>Melatonin - therapeutic use</subject><subject>Neuroimmunomodulation - drug effects</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rheumatology</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1LxDAQhoMoun78AC8S8OKlOkk2TXMU8QtcFNFzTJOpW-m2a9Ie-u_NsioiCJ5mYJ55J-Eh5JDBKQNQZ5GBkiIDlmcgtM7GDTJhUomMS5VvkgmIHLI0UDtkN8Y3ACh0IbbJDldCFZLrCXmZYWP7rq1bet70GCLt50hn6Oa2rZ1tqG09fZpjWKT-ZlxisM0rxtrS29YPDj0tR3ofusq6OhEPNgXNOo8NTc2j7eM-2apsE_Hgs-6R56vLp4ub7O7--vbi_C5zU5B9lksE4NP0VqddLiQXHnVpldcaylJVjLsiV7IAhtyXXLhSl8oKKSwTlfZW7JGTde4ydO8Dxt4s6uiwaWyL3RANK7jSAkCo_6Ag9VSrFXr8C33rhtCmjySKaVYoBjpRbE250MUYsDLLUC9sGA0DszJl1qZMMmVWpsyYdo4-k4dygf5740tNAvgaiGnUvmL4cfrP1A_uP50K</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Scarabelot, Vanessa Leal</creator><creator>Medeiros, Liciane Fernandes</creator><creator>de Oliveira, Carla</creator><creator>Adachi, Lauren Naomi Spezia</creator><creator>de Macedo, Isabel Cristina</creator><creator>Cioato, Stefania Giotti</creator><creator>de Freitas, Joice S.</creator><creator>de Souza, Andressa</creator><creator>Quevedo, Alexandre</creator><creator>Caumo, Wolnei</creator><creator>Torres, Iraci Lucena da Silva</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats</title><author>Scarabelot, Vanessa Leal ; 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In addition, melatonin has received special attention in pain treatment since it is effective and presents few adverse effects. In this study, we evaluated the effect of acute dose of melatonin upon hyperalgesia induced by complete Freund’s adjuvant in a chronic orofacial pain model in Sprague–Dawley rats. Nociceptive behavior was assessed by facial Von Frey and the hot plate tests at baseline and thereafter 30, 60, and 120 min, 24 h, and 7 days after melatonin treatment. We demonstrated that acute melatonin administration alters mechanical and thermal hyperalgesia induced by an orofacial pain model (TMD), highlighting that the melatonin effect upon mechanical hyperalgesia remained until 7 days after its administration. Besides, we observed specific tissue profiles of neuroimmunomodulators linked to pain conditions and/or melatonin effect (brain-derived neurotrophic factor, nerve growth factor, and interleukins 6 and 10) in the brainstem levels, and its effects were state-dependent of the baseline of these animals.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27378529</pmid><doi>10.1007/s10753-016-0399-y</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Biomedical and Life Sciences Biomedicine Brain Stem - metabolism Facial Pain - complications Freund's Adjuvant Hyperalgesia - chemically induced Hyperalgesia - drug therapy Immunology Internal Medicine Melatonin - pharmacology Melatonin - therapeutic use Neuroimmunomodulation - drug effects Original Article Pathology Pharmacology/Toxicology Rats Rats, Sprague-Dawley Rheumatology |
| title | Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats |
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