Effect of atorvastatin on plasma NT-proBNP and inflammatory cytokine expression in patients with heart failure
The aim of this study was to explore the effect of atorvastatin intervention on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory cytokine levels in patients with heart failure (HF). One hundred and twenty-three HF patients were selected from our hospital and randomly div...
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| Veröffentlicht in: | Genetics and molecular research 2015-01, Vol.14 (4), p.15739-15748 |
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| creator | Duan, H Y Liu, D M Qian, P Wang, S L Yan, L J Wu, J T Yang, H T Fan, X W Chu, Y J |
| description | The aim of this study was to explore the effect of atorvastatin intervention on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory cytokine levels in patients with heart failure (HF). One hundred and twenty-three HF patients were selected from our hospital and randomly divided into control (N = 61) and observation (N = 62) groups; the former received conventional treatment, while the latter were given conventional treatment combined with atorvastatin. Plasma NT-proBNP, inflammatory cytokines [high-sensitive C-reactive protein (hs-CRP), interleukin (IL)-6, IL-10] and cardiac function [left ventricular end-diastolic dimension (LVEDD), left ventricular ejection fraction (LVEF), end-diastolic maximum flow rate ratio (E/A)] were compared among groups. The effective rate of treating HF significantly increased after atorvastatin treatment. The plasma NT-proBNP, IL-6, IL-10, hs-CRP, and LVEDD levels significantly decreased (P < 0.05), while the LVEF and E/A levels significantly increased (P < 0.05) in the observation group compared to the control group and before intervention. The NT-proBNP and cytokine levels significantly differed among patients with different classes of heart function (P < 0.05); the NT-proBNP and cytokine levels increased with the severity of heart function. Pearson's correlation analysis revealed a negative correlation between the NT-proBNP and inflammatory cytokine levels and LVEF and E/A values, and a positive correlation between these factors and LVEDD (P < 0.05). In conclusion, atorvastatin significantly improves cardiac function; the mechanism atorvastatin action was related to the decrease in plasma NT-proBNP and inflammatory cytokine levels. |
| doi_str_mv | 10.4238/2015.December.1.25 |
| format | Article |
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One hundred and twenty-three HF patients were selected from our hospital and randomly divided into control (N = 61) and observation (N = 62) groups; the former received conventional treatment, while the latter were given conventional treatment combined with atorvastatin. Plasma NT-proBNP, inflammatory cytokines [high-sensitive C-reactive protein (hs-CRP), interleukin (IL)-6, IL-10] and cardiac function [left ventricular end-diastolic dimension (LVEDD), left ventricular ejection fraction (LVEF), end-diastolic maximum flow rate ratio (E/A)] were compared among groups. The effective rate of treating HF significantly increased after atorvastatin treatment. The plasma NT-proBNP, IL-6, IL-10, hs-CRP, and LVEDD levels significantly decreased (P < 0.05), while the LVEF and E/A levels significantly increased (P < 0.05) in the observation group compared to the control group and before intervention. The NT-proBNP and cytokine levels significantly differed among patients with different classes of heart function (P < 0.05); the NT-proBNP and cytokine levels increased with the severity of heart function. Pearson's correlation analysis revealed a negative correlation between the NT-proBNP and inflammatory cytokine levels and LVEF and E/A values, and a positive correlation between these factors and LVEDD (P < 0.05). In conclusion, atorvastatin significantly improves cardiac function; the mechanism atorvastatin action was related to the decrease in plasma NT-proBNP and inflammatory cytokine levels.</description><identifier>ISSN: 1676-5680</identifier><identifier>EISSN: 1676-5680</identifier><identifier>DOI: 10.4238/2015.December.1.25</identifier><identifier>PMID: 26634541</identifier><language>eng</language><publisher>Brazil</publisher><subject>Adult ; Aged ; Atorvastatin Calcium - therapeutic use ; Biomarkers ; Case-Control Studies ; Cytokines - blood ; Echocardiography ; Female ; Heart Failure - blood ; Heart Failure - diagnosis ; Heart Failure - drug therapy ; Heart Failure - physiopathology ; Heart Function Tests ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Inflammation Mediators - blood ; Male ; Middle Aged ; Natriuretic Peptide, Brain - blood ; Peptide Fragments - blood ; Treatment Outcome</subject><ispartof>Genetics and molecular research, 2015-01, Vol.14 (4), p.15739-15748</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-47af343ad0bbfeba91e88ccc524a8b0479419b43f95bf631b5dbe720745833443</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26634541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duan, H Y</creatorcontrib><creatorcontrib>Liu, D M</creatorcontrib><creatorcontrib>Qian, P</creatorcontrib><creatorcontrib>Wang, S L</creatorcontrib><creatorcontrib>Yan, L J</creatorcontrib><creatorcontrib>Wu, J T</creatorcontrib><creatorcontrib>Yang, H T</creatorcontrib><creatorcontrib>Fan, X W</creatorcontrib><creatorcontrib>Chu, Y J</creatorcontrib><title>Effect of atorvastatin on plasma NT-proBNP and inflammatory cytokine expression in patients with heart failure</title><title>Genetics and molecular research</title><addtitle>Genet Mol Res</addtitle><description>The aim of this study was to explore the effect of atorvastatin intervention on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory cytokine levels in patients with heart failure (HF). One hundred and twenty-three HF patients were selected from our hospital and randomly divided into control (N = 61) and observation (N = 62) groups; the former received conventional treatment, while the latter were given conventional treatment combined with atorvastatin. Plasma NT-proBNP, inflammatory cytokines [high-sensitive C-reactive protein (hs-CRP), interleukin (IL)-6, IL-10] and cardiac function [left ventricular end-diastolic dimension (LVEDD), left ventricular ejection fraction (LVEF), end-diastolic maximum flow rate ratio (E/A)] were compared among groups. The effective rate of treating HF significantly increased after atorvastatin treatment. The plasma NT-proBNP, IL-6, IL-10, hs-CRP, and LVEDD levels significantly decreased (P < 0.05), while the LVEF and E/A levels significantly increased (P < 0.05) in the observation group compared to the control group and before intervention. The NT-proBNP and cytokine levels significantly differed among patients with different classes of heart function (P < 0.05); the NT-proBNP and cytokine levels increased with the severity of heart function. Pearson's correlation analysis revealed a negative correlation between the NT-proBNP and inflammatory cytokine levels and LVEF and E/A values, and a positive correlation between these factors and LVEDD (P < 0.05). In conclusion, atorvastatin significantly improves cardiac function; the mechanism atorvastatin action was related to the decrease in plasma NT-proBNP and inflammatory cytokine levels.</description><subject>Adult</subject><subject>Aged</subject><subject>Atorvastatin Calcium - therapeutic use</subject><subject>Biomarkers</subject><subject>Case-Control Studies</subject><subject>Cytokines - blood</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Function Tests</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Inflammation Mediators - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Peptide Fragments - blood</subject><subject>Treatment Outcome</subject><issn>1676-5680</issn><issn>1676-5680</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkblOAzEURS0EYgn8AAVySTPB64ynZAmLhAJFqC3beVYGZsN2gPw9E4UgOiq_4p4jSwehU0rGgnF1wQiV4xtw0FgIYzpmcgcd0rzIM5krsvvnPkBHMb4SwqRQZB8dsDznQgp6iNqJ9-AS7jw2qQsfJiaTqhZ3Le5rExuDp7OsD93V9Bmbdo6r1temadbbFXar1L1VLWD46gPEWA3UwPaDAdoU8WeVFngBJiTsTVUvAxyjPW_qCCc_7wi93E5m1_fZ49Pdw_XlY-a4IikThfFccDMn1nqwpqSglHNOMmGUJaIoBS2t4L6U1uecWjm3UDBSCKk4F4KP0PnGO3z9fQkx6aaKDuratNAto6aKFSWThJX_Twsh8lyocm1lm6kLXYwBvO5D1Ziw0pTodRK9TqK3STTVTA7Q2Y9_aRuY_yLbBvwbyzCKXQ</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Duan, H Y</creator><creator>Liu, D M</creator><creator>Qian, P</creator><creator>Wang, S L</creator><creator>Yan, L J</creator><creator>Wu, J T</creator><creator>Yang, H T</creator><creator>Fan, X W</creator><creator>Chu, Y J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20150101</creationdate><title>Effect of atorvastatin on plasma NT-proBNP and inflammatory cytokine expression in patients with heart failure</title><author>Duan, H Y ; Liu, D M ; Qian, P ; Wang, S L ; Yan, L J ; Wu, J T ; Yang, H T ; Fan, X W ; Chu, Y J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-47af343ad0bbfeba91e88ccc524a8b0479419b43f95bf631b5dbe720745833443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Atorvastatin Calcium - therapeutic use</topic><topic>Biomarkers</topic><topic>Case-Control Studies</topic><topic>Cytokines - blood</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Function Tests</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Inflammation Mediators - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Peptide Fragments - blood</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duan, H Y</creatorcontrib><creatorcontrib>Liu, D M</creatorcontrib><creatorcontrib>Qian, P</creatorcontrib><creatorcontrib>Wang, S L</creatorcontrib><creatorcontrib>Yan, L J</creatorcontrib><creatorcontrib>Wu, J T</creatorcontrib><creatorcontrib>Yang, H T</creatorcontrib><creatorcontrib>Fan, X W</creatorcontrib><creatorcontrib>Chu, Y J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Genetics and molecular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duan, H Y</au><au>Liu, D M</au><au>Qian, P</au><au>Wang, S L</au><au>Yan, L J</au><au>Wu, J T</au><au>Yang, H T</au><au>Fan, X W</au><au>Chu, Y J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of atorvastatin on plasma NT-proBNP and inflammatory cytokine expression in patients with heart failure</atitle><jtitle>Genetics and molecular research</jtitle><addtitle>Genet Mol Res</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>14</volume><issue>4</issue><spage>15739</spage><epage>15748</epage><pages>15739-15748</pages><issn>1676-5680</issn><eissn>1676-5680</eissn><abstract>The aim of this study was to explore the effect of atorvastatin intervention on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory cytokine levels in patients with heart failure (HF). One hundred and twenty-three HF patients were selected from our hospital and randomly divided into control (N = 61) and observation (N = 62) groups; the former received conventional treatment, while the latter were given conventional treatment combined with atorvastatin. Plasma NT-proBNP, inflammatory cytokines [high-sensitive C-reactive protein (hs-CRP), interleukin (IL)-6, IL-10] and cardiac function [left ventricular end-diastolic dimension (LVEDD), left ventricular ejection fraction (LVEF), end-diastolic maximum flow rate ratio (E/A)] were compared among groups. The effective rate of treating HF significantly increased after atorvastatin treatment. The plasma NT-proBNP, IL-6, IL-10, hs-CRP, and LVEDD levels significantly decreased (P < 0.05), while the LVEF and E/A levels significantly increased (P < 0.05) in the observation group compared to the control group and before intervention. The NT-proBNP and cytokine levels significantly differed among patients with different classes of heart function (P < 0.05); the NT-proBNP and cytokine levels increased with the severity of heart function. Pearson's correlation analysis revealed a negative correlation between the NT-proBNP and inflammatory cytokine levels and LVEF and E/A values, and a positive correlation between these factors and LVEDD (P < 0.05). In conclusion, atorvastatin significantly improves cardiac function; the mechanism atorvastatin action was related to the decrease in plasma NT-proBNP and inflammatory cytokine levels.</abstract><cop>Brazil</cop><pmid>26634541</pmid><doi>10.4238/2015.December.1.25</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Atorvastatin Calcium - therapeutic use Biomarkers Case-Control Studies Cytokines - blood Echocardiography Female Heart Failure - blood Heart Failure - diagnosis Heart Failure - drug therapy Heart Failure - physiopathology Heart Function Tests Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Inflammation Mediators - blood Male Middle Aged Natriuretic Peptide, Brain - blood Peptide Fragments - blood Treatment Outcome |
| title | Effect of atorvastatin on plasma NT-proBNP and inflammatory cytokine expression in patients with heart failure |
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