Association of axitinib plasma exposure and genetic polymorphisms of ABC transporters with axitinib-induced toxicities in patients with renal cell carcinoma

Purpose Axitinib is a selective tyrosine kinase inhibitor of VEGF receptors, approved for advanced renal cell carcinoma (RCC). Associations between axitinib plasma exposure, genetic polymorphisms of ABC transporters and axitinib-induced toxicities have not been adequately explored. Methods Twenty RC...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2016-10, Vol.78 (4), p.855-862
Hauptverfasser:	Kato, Hiroshi, Sassa, Naoto, Miyazaki, Masayuki, Takeuchi, Mio, Asai, Miho, Iwai, Akane, Noda, Yukihiro, Gotoh, Momokazu, Yamada, Kiyofumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Area Under Curve ATP Binding Cassette Transporter, Sub-Family B - genetics ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics ATP-Binding Cassette Transporters - genetics Cancer Research Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - genetics Female Genotype Humans Imidazoles - adverse effects Imidazoles - blood Imidazoles - therapeutic use Indazoles - adverse effects Indazoles - blood Indazoles - therapeutic use Kidney Neoplasms - drug therapy Kidney Neoplasms - genetics Male Medicine Medicine & Public Health Middle Aged Neoplasm Proteins - genetics Oncology Original Article Pharmacology/Toxicology Polymorphism, Genetic - genetics Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Retrospective Studies Treatment Failure
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