IFN‐α promotes rapid human Treg contraction and late Th1‐like Treg decrease

IFN‐α restrains Tregs in vitro and in vivo via induced apoptosis, a decrease in Th1‐like Tregs, inhibiting IL‐12‐driven polarization, and depleting IL‐12 sources. Type I IFNs are pleiotropic cytokines that exert concerted activities in the development of antiviral responses. Regulatory T cells repre...

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Veröffentlicht in:	Journal of leukocyte biology 2016-09, Vol.100 (3), p.613-623
Hauptverfasser:	Pacella, Ilenia, Timperi, Eleonora, Accapezzato, Daniele, Martire, Carmela, Labbadia, Giancarlo, Cavallari, Eugenio N., D'Ettorre, Gabriella, Calvo, Ludovica, Rizzo, Fabiana, Severa, Martina, Coccia, Eliana M., Vullo, Vincenzo, Barnaba, Vincenzo, Piconese, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antiviral Agents - pharmacology apoptosis Cytokines - metabolism Dendritic Cells - drug effects Dendritic Cells - immunology desensitization Female Hepacivirus - immunology Hepatitis C virus Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - immunology Hepatitis C, Chronic - virology Humans IL‐12 Interferon-alpha - pharmacology Lymphocyte Activation Male Middle Aged STAT T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th1 Cells - drug effects Th1 Cells - immunology
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