Dexamethasone for the prevention of postoperative sore throat: a systematic review and meta-analysis
Abstract Study Objective To determine the antiemetic efficacy of dexamethasone in the prevention of postoperative sore throat (POST) and postoperative hoarseness (PH). Design Meta-analysis. Setting Metropolitan university medical center. Measurements This systematic review and meta-analysis was cond...
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| Veröffentlicht in: | Journal of clinical anesthesia 2015-02, Vol.27 (1), p.45-50 |
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| creator | Zhao, Xiang, MD Cao, Xiuhong, MD Li, Quan, MD, PhD |
| description | Abstract Study Objective To determine the antiemetic efficacy of dexamethasone in the prevention of postoperative sore throat (POST) and postoperative hoarseness (PH). Design Meta-analysis. Setting Metropolitan university medical center. Measurements This systematic review and meta-analysis was conducted and reported in agreement with the PRISMA guideline. We searched online databases of MEDLINE (from 1966 to August 2013), EMBASE (from 1982 to August 2013), Google Scholar, and the Cochrane Database of Systematic Review. Relative ratios (RRs) and 95% confidence interval (CI) were calculated. Results Four trials with a total of 480 patients were included for the analysis: 283 received prophylactic dexamethasone and 197 received placebo. Pooled result by random-effects model showed that dexamethasone significantly decreased the incidence of POST at 1 hour (RR = 0.51, 95% CI 0.27-0.94, P = .03; P for heterogeneity = .0005, I2 = 83%) and at 24 hour postextubation (RR = 0.46, 95% CI 0.26-0.79, P < .05; P for heterogeneity = .01, I2 = 72%). Our analysis indicated that dexamethasone significantly decreased the incidence of PH at 1 hour (RR = 0.22, 95% CI 0.11-0.46, P < .01; P for heterogeneity = .48, I2 = 0%), but did not affect the incidence of PH at 24 hours postextubation (RR = 0.67, 95% CI 0.37-1.20, P > .1; P for heterogeneity = .12, I2 = 59%). Conclusion Our meta-analysis suggested that intravenous dexamethasone can effectively reduce the incidence of POST both at 1 and at 24 hours postextubation. In addition, the present study showed that prophylactic dexamethasone reduced the incidence of PH at 1 hours but not at 24 hours postextubation. |
| doi_str_mv | 10.1016/j.jclinane.2014.06.014 |
| format | Article |
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Design Meta-analysis. Setting Metropolitan university medical center. Measurements This systematic review and meta-analysis was conducted and reported in agreement with the PRISMA guideline. We searched online databases of MEDLINE (from 1966 to August 2013), EMBASE (from 1982 to August 2013), Google Scholar, and the Cochrane Database of Systematic Review. Relative ratios (RRs) and 95% confidence interval (CI) were calculated. Results Four trials with a total of 480 patients were included for the analysis: 283 received prophylactic dexamethasone and 197 received placebo. Pooled result by random-effects model showed that dexamethasone significantly decreased the incidence of POST at 1 hour (RR = 0.51, 95% CI 0.27-0.94, P = .03; P for heterogeneity = .0005, I2 = 83%) and at 24 hour postextubation (RR = 0.46, 95% CI 0.26-0.79, P < .05; P for heterogeneity = .01, I2 = 72%). Our analysis indicated that dexamethasone significantly decreased the incidence of PH at 1 hour (RR = 0.22, 95% CI 0.11-0.46, P < .01; P for heterogeneity = .48, I2 = 0%), but did not affect the incidence of PH at 24 hours postextubation (RR = 0.67, 95% CI 0.37-1.20, P > .1; P for heterogeneity = .12, I2 = 59%). Conclusion Our meta-analysis suggested that intravenous dexamethasone can effectively reduce the incidence of POST both at 1 and at 24 hours postextubation. In addition, the present study showed that prophylactic dexamethasone reduced the incidence of PH at 1 hours but not at 24 hours postextubation.</description><identifier>ISSN: 0952-8180</identifier><identifier>EISSN: 1873-4529</identifier><identifier>DOI: 10.1016/j.jclinane.2014.06.014</identifier><identifier>PMID: 25468585</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject><![CDATA[Anesthesia & Perioperative Care ; Anti-Inflammatory Agents - administration & dosage ; Confidence intervals ; Data analysis ; Dexamethasone ; Dexamethasone - administration & dosage ; Hoarseness - etiology ; Hoarseness - prevention & control ; Humans ; Incidence ; Intubation ; Intubation, Intratracheal - adverse effects ; Meta-analysis ; Methods ; Pain Medicine ; Pharyngitis - etiology ; Pharyngitis - prevention & control ; POST ; Postoperative Complications - prevention & control ; Postoperative sore throat ; Studies ; Surgery ; Time Factors]]></subject><ispartof>Journal of clinical anesthesia, 2015-02, Vol.27 (1), p.45-50</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-5dd1611415ad85fcddaaf7f73baca15cde24dff5e1ec81ad980528a0a524c74e3</citedby><cites>FETCH-LOGICAL-c484t-5dd1611415ad85fcddaaf7f73baca15cde24dff5e1ec81ad980528a0a524c74e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1656372788?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25468585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Xiang, MD</creatorcontrib><creatorcontrib>Cao, Xiuhong, MD</creatorcontrib><creatorcontrib>Li, Quan, MD, PhD</creatorcontrib><title>Dexamethasone for the prevention of postoperative sore throat: a systematic review and meta-analysis</title><title>Journal of clinical anesthesia</title><addtitle>J Clin Anesth</addtitle><description>Abstract Study Objective To determine the antiemetic efficacy of dexamethasone in the prevention of postoperative sore throat (POST) and postoperative hoarseness (PH). Design Meta-analysis. Setting Metropolitan university medical center. Measurements This systematic review and meta-analysis was conducted and reported in agreement with the PRISMA guideline. We searched online databases of MEDLINE (from 1966 to August 2013), EMBASE (from 1982 to August 2013), Google Scholar, and the Cochrane Database of Systematic Review. Relative ratios (RRs) and 95% confidence interval (CI) were calculated. Results Four trials with a total of 480 patients were included for the analysis: 283 received prophylactic dexamethasone and 197 received placebo. Pooled result by random-effects model showed that dexamethasone significantly decreased the incidence of POST at 1 hour (RR = 0.51, 95% CI 0.27-0.94, P = .03; P for heterogeneity = .0005, I2 = 83%) and at 24 hour postextubation (RR = 0.46, 95% CI 0.26-0.79, P < .05; P for heterogeneity = .01, I2 = 72%). Our analysis indicated that dexamethasone significantly decreased the incidence of PH at 1 hour (RR = 0.22, 95% CI 0.11-0.46, P < .01; P for heterogeneity = .48, I2 = 0%), but did not affect the incidence of PH at 24 hours postextubation (RR = 0.67, 95% CI 0.37-1.20, P > .1; P for heterogeneity = .12, I2 = 59%). Conclusion Our meta-analysis suggested that intravenous dexamethasone can effectively reduce the incidence of POST both at 1 and at 24 hours postextubation. In addition, the present study showed that prophylactic dexamethasone reduced the incidence of PH at 1 hours but not at 24 hours postextubation.</description><subject>Anesthesia & Perioperative Care</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Confidence intervals</subject><subject>Data analysis</subject><subject>Dexamethasone</subject><subject>Dexamethasone - administration & dosage</subject><subject>Hoarseness - etiology</subject><subject>Hoarseness - prevention & control</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intubation</subject><subject>Intubation, Intratracheal - adverse effects</subject><subject>Meta-analysis</subject><subject>Methods</subject><subject>Pain Medicine</subject><subject>Pharyngitis - etiology</subject><subject>Pharyngitis - prevention & control</subject><subject>POST</subject><subject>Postoperative Complications - prevention & control</subject><subject>Postoperative sore throat</subject><subject>Studies</subject><subject>Surgery</subject><subject>Time Factors</subject><issn>0952-8180</issn><issn>1873-4529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFks1u1TAQhS0EopfCK1SW2LBJsB07cVggUPmVKrEA1tbUnqgOSRxs38J9exxuC1I3Xc1ivjmjOWcIOeOs5oy3L8d6tJNfYMFaMC5r1talPCA7rrumkkr0D8mO9UpUmmt2Qp6kNDLGSoM_JidCyVYrrXbEvcPfMGO-ghQWpEOINF8hXSNe45J9WGgY6BpSDitGyP4aaQoRCxQD5FcUaDqkjHNpWVqGPP6isDhaJKGCBaZD8ukpeTTAlPDZTT0l3z-8_3b-qbr48vHz-duLykotc6Wc4y3nkitwWg3WOYChG7rmEixwZR0K6YZBIUerObheMyU0MFBC2k5ic0peHHXXGH7uMWUz-2RxmopNYZ8M16LrRaMadj_aKi1FI2Vf0Od30DHsYzntL9U2nei0LlR7pGwMKUUczBr9DPFgODNbZGY0t5GZLTLDWlNKGTy7kd9fzuj-jd1mVIA3RwCLdcXgaJL1uFh0PqLNxgV__47XdyQ2yluYfuAB0_97TBKGma_b42x_wyVjTfGr-QM9tME_</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Zhao, Xiang, MD</creator><creator>Cao, Xiuhong, MD</creator><creator>Li, Quan, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20150201</creationdate><title>Dexamethasone for the prevention of postoperative sore throat: a systematic review and meta-analysis</title><author>Zhao, Xiang, MD ; Cao, Xiuhong, MD ; Li, Quan, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-5dd1611415ad85fcddaaf7f73baca15cde24dff5e1ec81ad980528a0a524c74e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Anesthesia & Perioperative Care</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Confidence intervals</topic><topic>Data analysis</topic><topic>Dexamethasone</topic><topic>Dexamethasone - administration & dosage</topic><topic>Hoarseness - etiology</topic><topic>Hoarseness - prevention & control</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intubation</topic><topic>Intubation, Intratracheal - adverse effects</topic><topic>Meta-analysis</topic><topic>Methods</topic><topic>Pain Medicine</topic><topic>Pharyngitis - etiology</topic><topic>Pharyngitis - prevention & control</topic><topic>POST</topic><topic>Postoperative Complications - prevention & control</topic><topic>Postoperative sore throat</topic><topic>Studies</topic><topic>Surgery</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Xiang, MD</creatorcontrib><creatorcontrib>Cao, Xiuhong, MD</creatorcontrib><creatorcontrib>Li, Quan, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of clinical anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Xiang, MD</au><au>Cao, Xiuhong, MD</au><au>Li, Quan, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dexamethasone for the prevention of postoperative sore throat: a systematic review and meta-analysis</atitle><jtitle>Journal of clinical anesthesia</jtitle><addtitle>J Clin Anesth</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>27</volume><issue>1</issue><spage>45</spage><epage>50</epage><pages>45-50</pages><issn>0952-8180</issn><eissn>1873-4529</eissn><abstract>Abstract Study Objective To determine the antiemetic efficacy of dexamethasone in the prevention of postoperative sore throat (POST) and postoperative hoarseness (PH). Design Meta-analysis. Setting Metropolitan university medical center. Measurements This systematic review and meta-analysis was conducted and reported in agreement with the PRISMA guideline. We searched online databases of MEDLINE (from 1966 to August 2013), EMBASE (from 1982 to August 2013), Google Scholar, and the Cochrane Database of Systematic Review. Relative ratios (RRs) and 95% confidence interval (CI) were calculated. Results Four trials with a total of 480 patients were included for the analysis: 283 received prophylactic dexamethasone and 197 received placebo. Pooled result by random-effects model showed that dexamethasone significantly decreased the incidence of POST at 1 hour (RR = 0.51, 95% CI 0.27-0.94, P = .03; P for heterogeneity = .0005, I2 = 83%) and at 24 hour postextubation (RR = 0.46, 95% CI 0.26-0.79, P < .05; P for heterogeneity = .01, I2 = 72%). Our analysis indicated that dexamethasone significantly decreased the incidence of PH at 1 hour (RR = 0.22, 95% CI 0.11-0.46, P < .01; P for heterogeneity = .48, I2 = 0%), but did not affect the incidence of PH at 24 hours postextubation (RR = 0.67, 95% CI 0.37-1.20, P > .1; P for heterogeneity = .12, I2 = 59%). Conclusion Our meta-analysis suggested that intravenous dexamethasone can effectively reduce the incidence of POST both at 1 and at 24 hours postextubation. In addition, the present study showed that prophylactic dexamethasone reduced the incidence of PH at 1 hours but not at 24 hours postextubation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25468585</pmid><doi>10.1016/j.jclinane.2014.06.014</doi><tpages>6</tpages></addata></record> |
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| subjects | Anesthesia & Perioperative Care Anti-Inflammatory Agents - administration & dosage Confidence intervals Data analysis Dexamethasone Dexamethasone - administration & dosage Hoarseness - etiology Hoarseness - prevention & control Humans Incidence Intubation Intubation, Intratracheal - adverse effects Meta-analysis Methods Pain Medicine Pharyngitis - etiology Pharyngitis - prevention & control POST Postoperative Complications - prevention & control Postoperative sore throat Studies Surgery Time Factors |
| title | Dexamethasone for the prevention of postoperative sore throat: a systematic review and meta-analysis |
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