Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone

Ewing sarcoma (ES) is a small round-cell tumor of the bones and soft tissues. ES frequently causes distant metastases, particularly in the lung and bone, which worsens patient prognosis. Cadherin-11 (Cad-11) is an adhesion molecule that is highly expressed in osteoblasts. Its expression is associate...

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Veröffentlicht in:	Clinical & experimental metastasis 2015-08, Vol.32 (6), p.579-591
Hauptverfasser:	Hatano, Mihoko, Matsumoto, Yoshihiro, Fukushi, Jun-ichi, Matsunobu, Tomoya, Endo, Makoto, Okada, Seiji, Iura, Kunio, Kamura, Satoshi, Fujiwara, Toshifumi, Iida, Keiichiro, Fujiwara, Yuko, Nabeshima, Akira, Yokoyama, Nobuhiko, Fukushima, Suguru, Oda, Yoshinao, Iwamoto, Yukihide
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Apoptosis Biomedical and Life Sciences Biomedicine Blotting, Western Bone Neoplasms - metabolism Bone Neoplasms - mortality Bone Neoplasms - secondary Cadherins - antagonists & inhibitors Cadherins - immunology Cadherins - metabolism Cancer Research Cell Adhesion Cell Movement Cell Proliferation Coculture Techniques Female Flow Cytometry Hematology Humans Immunoenzyme Techniques Lentivirus Luciferases - metabolism Mice Mice, Inbred BALB C Mice, Nude Neoplasm Staging Oncology Osteoblasts - metabolism Osteoblasts - pathology Prognosis Real-Time Polymerase Chain Reaction Research Paper Retroviridae Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Sarcoma, Ewing - metabolism Sarcoma, Ewing - mortality Sarcoma, Ewing - pathology Surgical Oncology Survival Rate Tumor Cells, Cultured Wound Healing Xenograft Model Antitumor Assays
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