Trivalent ligands for CXCR4 bearing polyproline linkers show specific recognition for cells with increased CXCR4 expression

The assembly status of G protein-coupled receptors (GPCR) on the cell surface is of interest because the multimerization of GPCR could play pivotal roles in cellular functions. A bivalent ligand with polyproline linkers for CXCR4 has been shown to serve as a "molecular ruler" as a result o...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic & biomolecular chemistry 2015-08, Vol.13 (32), p.8734-8739
Hauptverfasser:	Nomura, Wataru, Koseki, Taisuke, Ohashi, Nami, Mizuguchi, Takaaki, Tamamura, Hirokazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Dose-Response Relationship, Drug HeLa Cells Humans Jurkat Cells K562 Cells Ligands Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology Receptors, CXCR4 - analysis Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - biosynthesis Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!