A mutation within the SH2 domain of slp‐76 regulates the tissue distribution and cytokine production of iNKT cells in mice

TCR ligation is critical for the selection, activation, and integrin expression of T lymphocytes. Here, we explored the role of the TCR adaptor protein slp‐76 on iNKT‐cell biology. Compared to B6 controls, slp‐76ace/ace mice carrying a missense mutation (Thr428Ile) within the SH2‐domain of slp‐76 sh...

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Veröffentlicht in:	European journal of immunology 2016-09, Vol.46 (9), p.2121-2136
Hauptverfasser:	Danzer, Claudia, Koller, Anna, Baier, Julia, Arnold, Harald, Giessler, Claudia, Opoka, Robert, Schmidt, Stephanie, Willers, Maike, Mihai, Sidonia, Parsch, Hans, Wirtz, Stefan, Daniel, Christoph, Reinhold, Annegret, Engelmann, Swen, Kliche, Stefanie, Bogdan, Christian, Hoebe, Kasper, Mattner, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAP Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adhesion Animals Biomarkers C-Reactive Protein - genetics C-Reactive Protein - metabolism CD11b antigen CD11b Antigen - genetics CD11b Antigen - metabolism Cell activation Concanavalin A Cytokine Cytokines Cytokines - biosynthesis Gene Deletion Gene Expression Hepatitis - etiology Hepatitis - metabolism Hepatitis - pathology Hepatocytes Inhibitor of Differentiation Proteins - genetics Inhibitor of Differentiation Proteins - metabolism iNKT cell Integrin Intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - metabolism Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Liver Liver - immunology Lymph nodes Lymph Nodes - immunology Lymphatic system Lymphocyte Function-Associated Antigen-1 - genetics Lymphocyte Function-Associated Antigen-1 - metabolism Lymphocytes Lymphocytes T Mice Mice, Knockout Missense mutation Mutation Natural Killer T-Cells - immunology Natural Killer T-Cells - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nur77 protein Organ Specificity - immunology Phenotype Phosphoproteins - chemistry Phosphoproteins - genetics Phosphoproteins - metabolism Promyelocytic Leukemia Zinc Finger Protein Protein Binding Receptors, Antigen, T-Cell - metabolism Rodents Signal Transduction SLP-76 protein slp‐76 Spleen - immunology src Homology Domains - genetics T cell receptors Thymus Thymus Gland - immunology Transcription factors
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