Lymph node size as a simple prognostic factor in node negative colon cancer and an alternative thesis to stage migration
Abstract Background Stage migration is an accepted explanation for the association between lymph node (LN) yield and outcome in colon cancer. To investigate whether the alternative thesis of immune response is more likely, we performed a retrospective study. Methods We enrolled 239 cases of node neg...
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| Veröffentlicht in: | The American journal of surgery 2016-10, Vol.212 (4), p.775-780 |
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| creator | Märkl, Bruno, M.D Schaller, Tina, M.D Kokot, Yuriy, M.D Endhardt, Katharina, M.D Kretsinger, Hallie, M.D Hirschbühl, Klaus, M.D Aumann, Georg, M.D Schenkirsch, Gerhard, M.D |
| description | Abstract Background Stage migration is an accepted explanation for the association between lymph node (LN) yield and outcome in colon cancer. To investigate whether the alternative thesis of immune response is more likely, we performed a retrospective study. Methods We enrolled 239 cases of node negative cancers, which were categorized according to the number of LNs with diameters larger than 5 mm (LN5) into the groups LN5-very low (0 to 1 LN5), LN5-low (2 to 5 LN5), and LN5-high (≥6 LN5). Results Significant differences were found in pT3/4 cancers with median survival times of 40, 57, and 71 months ( P = .022) in the LN5-very low, LN5-low, and LN5-high groups, respectively. Multivariable analysis revealed that LN5 number and infiltration type were independent prognostic factors. Conclusions LN size is prognostic in node negative colon cancer. The correct explanation for outcome differences associated with LN harvest is probably the activation status of LNs. |
| doi_str_mv | 10.1016/j.amjsurg.2015.05.026 |
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To investigate whether the alternative thesis of immune response is more likely, we performed a retrospective study. Methods We enrolled 239 cases of node negative cancers, which were categorized according to the number of LNs with diameters larger than 5 mm (LN5) into the groups LN5-very low (0 to 1 LN5), LN5-low (2 to 5 LN5), and LN5-high (≥6 LN5). Results Significant differences were found in pT3/4 cancers with median survival times of 40, 57, and 71 months ( P = .022) in the LN5-very low, LN5-low, and LN5-high groups, respectively. Multivariable analysis revealed that LN5 number and infiltration type were independent prognostic factors. Conclusions LN size is prognostic in node negative colon cancer. The correct explanation for outcome differences associated with LN harvest is probably the activation status of LNs.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2015.05.026</identifier><identifier>PMID: 26307422</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Aged ; Colon cancer ; Colonic Neoplasms - mortality ; Colonic Neoplasms - pathology ; Colorectal cancer ; Dissection ; Female ; Humans ; Immune response ; Immune system ; Lymph node ; Lymph Node Excision ; Lymph Nodes - pathology ; Lymphatic system ; Male ; Medical prognosis ; Metastasis ; Multivariate Analysis ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Review boards ; Size ; Stage migration ; Studies ; Surgery ; Survival Analysis ; Tumors</subject><ispartof>The American journal of surgery, 2016-10, Vol.212 (4), p.775-780</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 01, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-671e96126ae8ef263f2daaebe880af6db06bb6068ff36ba74b106ab958ca071d3</citedby><cites>FETCH-LOGICAL-c547t-671e96126ae8ef263f2daaebe880af6db06bb6068ff36ba74b106ab958ca071d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1828268029?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3538,27906,27907,45977,64365,64367,64369,72219</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26307422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Märkl, Bruno, M.D</creatorcontrib><creatorcontrib>Schaller, Tina, M.D</creatorcontrib><creatorcontrib>Kokot, Yuriy, M.D</creatorcontrib><creatorcontrib>Endhardt, Katharina, M.D</creatorcontrib><creatorcontrib>Kretsinger, Hallie, M.D</creatorcontrib><creatorcontrib>Hirschbühl, Klaus, M.D</creatorcontrib><creatorcontrib>Aumann, Georg, M.D</creatorcontrib><creatorcontrib>Schenkirsch, Gerhard, M.D</creatorcontrib><title>Lymph node size as a simple prognostic factor in node negative colon cancer and an alternative thesis to stage migration</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background Stage migration is an accepted explanation for the association between lymph node (LN) yield and outcome in colon cancer. To investigate whether the alternative thesis of immune response is more likely, we performed a retrospective study. Methods We enrolled 239 cases of node negative cancers, which were categorized according to the number of LNs with diameters larger than 5 mm (LN5) into the groups LN5-very low (0 to 1 LN5), LN5-low (2 to 5 LN5), and LN5-high (≥6 LN5). Results Significant differences were found in pT3/4 cancers with median survival times of 40, 57, and 71 months ( P = .022) in the LN5-very low, LN5-low, and LN5-high groups, respectively. Multivariable analysis revealed that LN5 number and infiltration type were independent prognostic factors. Conclusions LN size is prognostic in node negative colon cancer. The correct explanation for outcome differences associated with LN harvest is probably the activation status of LNs.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - mortality</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colorectal cancer</subject><subject>Dissection</subject><subject>Female</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Lymph node</subject><subject>Lymph Node Excision</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Review boards</subject><subject>Size</subject><subject>Stage migration</subject><subject>Studies</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNklGP1CAQx4nReHurH0FD4osvXQfaUvZFc7l4arKJD-ozoXTao7awQntx_fRSu2pyL5oMATI_hvnzh5BnDHYMmHjV7_TYxzl0Ow6s3EEKLh6QDZPVPmNS5g_JBgB4thcMLshljH3aMlbkj8kFFzlUBecb8v1wGo-31PkGabQ_kOpIdVqNxwHpMfjO-ThZQ1ttJh-odSvqsNOTvUNq_OAdNdoZDFS7Jg2qhwmDW_PTLUYb6eRpnHSHdLRdSBnvnpBHrR4iPj3PW_Ll5u3n6_fZ4eO7D9dXh8yURTVlomKYFHChUWKb-m55ozXWKCXoVjQ1iLoWIGTb5qLWVVEzELrel9JoqFiTb8nLtW4S823GOKnRRoPDoB36OSomebXnwOX-f1AhuGBVkdAX99Dez0nz8ItKnAS-FCxXygQfY8BWHYMddTgpBmpxUfXq7KJaXFSQImnckufn6nM9YvPn1G_bEvBmBTC93J3FoKKxmDxobEAzqcbbf17x-l4FM1hnjR6-4gnjXzUqcgXq0_KVlp_ESoCCpRZ-Ao5ixiE</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Märkl, Bruno, M.D</creator><creator>Schaller, Tina, M.D</creator><creator>Kokot, Yuriy, M.D</creator><creator>Endhardt, Katharina, M.D</creator><creator>Kretsinger, Hallie, M.D</creator><creator>Hirschbühl, Klaus, M.D</creator><creator>Aumann, Georg, M.D</creator><creator>Schenkirsch, Gerhard, M.D</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Lymph node size as a simple prognostic factor in node negative colon cancer and an alternative thesis to stage migration</title><author>Märkl, Bruno, M.D ; Schaller, Tina, M.D ; Kokot, Yuriy, M.D ; Endhardt, Katharina, M.D ; Kretsinger, Hallie, M.D ; Hirschbühl, Klaus, M.D ; Aumann, Georg, M.D ; Schenkirsch, Gerhard, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-671e96126ae8ef263f2daaebe880af6db06bb6068ff36ba74b106ab958ca071d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - mortality</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colorectal cancer</topic><topic>Dissection</topic><topic>Female</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Lymph node</topic><topic>Lymph Node Excision</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Review boards</topic><topic>Size</topic><topic>Stage migration</topic><topic>Studies</topic><topic>Surgery</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Märkl, Bruno, M.D</creatorcontrib><creatorcontrib>Schaller, Tina, M.D</creatorcontrib><creatorcontrib>Kokot, Yuriy, M.D</creatorcontrib><creatorcontrib>Endhardt, Katharina, M.D</creatorcontrib><creatorcontrib>Kretsinger, Hallie, M.D</creatorcontrib><creatorcontrib>Hirschbühl, Klaus, M.D</creatorcontrib><creatorcontrib>Aumann, Georg, M.D</creatorcontrib><creatorcontrib>Schenkirsch, Gerhard, M.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Märkl, Bruno, M.D</au><au>Schaller, Tina, M.D</au><au>Kokot, Yuriy, M.D</au><au>Endhardt, Katharina, M.D</au><au>Kretsinger, Hallie, M.D</au><au>Hirschbühl, Klaus, M.D</au><au>Aumann, Georg, M.D</au><au>Schenkirsch, Gerhard, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymph node size as a simple prognostic factor in node negative colon cancer and an alternative thesis to stage migration</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>212</volume><issue>4</issue><spage>775</spage><epage>780</epage><pages>775-780</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Abstract Background Stage migration is an accepted explanation for the association between lymph node (LN) yield and outcome in colon cancer. To investigate whether the alternative thesis of immune response is more likely, we performed a retrospective study. Methods We enrolled 239 cases of node negative cancers, which were categorized according to the number of LNs with diameters larger than 5 mm (LN5) into the groups LN5-very low (0 to 1 LN5), LN5-low (2 to 5 LN5), and LN5-high (≥6 LN5). Results Significant differences were found in pT3/4 cancers with median survival times of 40, 57, and 71 months ( P = .022) in the LN5-very low, LN5-low, and LN5-high groups, respectively. Multivariable analysis revealed that LN5 number and infiltration type were independent prognostic factors. Conclusions LN size is prognostic in node negative colon cancer. The correct explanation for outcome differences associated with LN harvest is probably the activation status of LNs.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26307422</pmid><doi>10.1016/j.amjsurg.2015.05.026</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma - mortality Adenocarcinoma - pathology Aged Colon cancer Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colorectal cancer Dissection Female Humans Immune response Immune system Lymph node Lymph Node Excision Lymph Nodes - pathology Lymphatic system Male Medical prognosis Metastasis Multivariate Analysis Neoplasm Staging Prognosis Retrospective Studies Review boards Size Stage migration Studies Surgery Survival Analysis Tumors |
| title | Lymph node size as a simple prognostic factor in node negative colon cancer and an alternative thesis to stage migration |
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