Therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats
The aim of this study was to explore the therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats. Rats were fed high-fat fodder to establish a rat fatty liver model, and were then fed different concentrations of Pleurotus eryngii cellulose for six weeks. Lipitor was use...
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| Veröffentlicht in: | Genetics and molecular research 2016-02, Vol.15 (1), p.15017805-15017805 |
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| creator | Huang, J F Zhan, T Yu, X L He, Q A Huang, W J Lin, L Z Du, Y T Pan, Y T |
| description | The aim of this study was to explore the therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats. Rats were fed high-fat fodder to establish a rat fatty liver model, and were then fed different concentrations of Pleurotus eryngii cellulose for six weeks. Lipitor was used as a positive control. Measured levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), and total triglyceride (TG); the activity of malondialdehyde (MDA), superoxide dismutase (SOD), hepatic lipase (HL), and lipoprotein lipase; and liver histopathological changes. Successfully established rat fatty liver model after feeding high-fat fodder for one week. A diet of P. eryngii cellulose for six weeks significantly reduced ALT, AST, TC, and TG levels in rat serum (P < 0.01); TC and AST levels in P. eryngii cellulose high-dose group and Lipitor group were not significantly different from those of the control (P > 0.05). SOD activity increased significantly, while MDA and HL activity decreased (P < 0.05); fatty degeneration and fat accumulation both decreased in hepatic tissue. Hepatic protection of P. eryngii cellulose showed dose-related effect. P. eryngii cellulose can affect lipid metabolism, having therapeutic effects on fatty liver in rats. |
| doi_str_mv | 10.4238/gmr.15017805 |
| format | Article |
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Rats were fed high-fat fodder to establish a rat fatty liver model, and were then fed different concentrations of Pleurotus eryngii cellulose for six weeks. Lipitor was used as a positive control. Measured levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), and total triglyceride (TG); the activity of malondialdehyde (MDA), superoxide dismutase (SOD), hepatic lipase (HL), and lipoprotein lipase; and liver histopathological changes. Successfully established rat fatty liver model after feeding high-fat fodder for one week. A diet of P. eryngii cellulose for six weeks significantly reduced ALT, AST, TC, and TG levels in rat serum (P < 0.01); TC and AST levels in P. eryngii cellulose high-dose group and Lipitor group were not significantly different from those of the control (P > 0.05). SOD activity increased significantly, while MDA and HL activity decreased (P < 0.05); fatty degeneration and fat accumulation both decreased in hepatic tissue. Hepatic protection of P. eryngii cellulose showed dose-related effect. P. eryngii cellulose can affect lipid metabolism, having therapeutic effects on fatty liver in rats.</description><identifier>ISSN: 1676-5680</identifier><identifier>EISSN: 1676-5680</identifier><identifier>DOI: 10.4238/gmr.15017805</identifier><identifier>PMID: 26985922</identifier><language>eng</language><publisher>Brazil</publisher><subject>Alanine Transaminase - blood ; Animals ; Aspartate Aminotransferases - blood ; Cellulose - pharmacology ; Cellulose - therapeutic use ; Cholesterol - blood ; Disease Models, Animal ; Fatty Liver - blood ; Fatty Liver - drug therapy ; Lipid Metabolism - drug effects ; Liver - drug effects ; Male ; Pleurotus ; Pleurotus eryngii ; Rats ; Triglycerides - blood</subject><ispartof>Genetics and molecular research, 2016-02, Vol.15 (1), p.15017805-15017805</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-8a6b03229e758934746dfd2a6f8dc0c1faad5887fb2e71e2e586afdc3da86c93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26985922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, J F</creatorcontrib><creatorcontrib>Zhan, T</creatorcontrib><creatorcontrib>Yu, X L</creatorcontrib><creatorcontrib>He, Q A</creatorcontrib><creatorcontrib>Huang, W J</creatorcontrib><creatorcontrib>Lin, L Z</creatorcontrib><creatorcontrib>Du, Y T</creatorcontrib><creatorcontrib>Pan, Y T</creatorcontrib><title>Therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats</title><title>Genetics and molecular research</title><addtitle>Genet Mol Res</addtitle><description>The aim of this study was to explore the therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats. Rats were fed high-fat fodder to establish a rat fatty liver model, and were then fed different concentrations of Pleurotus eryngii cellulose for six weeks. Lipitor was used as a positive control. Measured levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), and total triglyceride (TG); the activity of malondialdehyde (MDA), superoxide dismutase (SOD), hepatic lipase (HL), and lipoprotein lipase; and liver histopathological changes. Successfully established rat fatty liver model after feeding high-fat fodder for one week. A diet of P. eryngii cellulose for six weeks significantly reduced ALT, AST, TC, and TG levels in rat serum (P < 0.01); TC and AST levels in P. eryngii cellulose high-dose group and Lipitor group were not significantly different from those of the control (P > 0.05). SOD activity increased significantly, while MDA and HL activity decreased (P < 0.05); fatty degeneration and fat accumulation both decreased in hepatic tissue. Hepatic protection of P. eryngii cellulose showed dose-related effect. P. eryngii cellulose can affect lipid metabolism, having therapeutic effects on fatty liver in rats.</description><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Cellulose - pharmacology</subject><subject>Cellulose - therapeutic use</subject><subject>Cholesterol - blood</subject><subject>Disease Models, Animal</subject><subject>Fatty Liver - blood</subject><subject>Fatty Liver - drug therapy</subject><subject>Lipid Metabolism - drug effects</subject><subject>Liver - drug effects</subject><subject>Male</subject><subject>Pleurotus</subject><subject>Pleurotus eryngii</subject><subject>Rats</subject><subject>Triglycerides - blood</subject><issn>1676-5680</issn><issn>1676-5680</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAURi0EoqWwMSOPDKT4ET8yooqXVAmGMkeuc12C8sJ2EPn3pGqL2NAdvjscfbr3IHRJyTxlXN9uaj-nglCliThCUyqVTITU5PjPPkFnIXwQwkSqySmaMJlpkTE2RW-rd_Cmgz6WFoNzYCNuHX6toPdt7AMGPzSbssQWqqqv2gC4bTB8d-DLGppoKuxMjAOuyi_wuGywNzGcoxNnqgAX-5yh1cP9avGULF8enxd3y8RyyWKijVwTzlgGSuiMpyqVhSuYkU4XlljqjCmE1sqtGSgKDISWxhWWF0ZLm_EZut7Vdr797CHEvC7D9lDTQNuHnGqmMkZoqv5HlUoFHycd0Zsdan0bggeXd-Ovxg85JflWeT4qzw_KR_xq39yvayh-4YNj_gPZSX2a</recordid><startdate>20160226</startdate><enddate>20160226</enddate><creator>Huang, J F</creator><creator>Zhan, T</creator><creator>Yu, X L</creator><creator>He, Q A</creator><creator>Huang, W J</creator><creator>Lin, L Z</creator><creator>Du, Y T</creator><creator>Pan, Y T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20160226</creationdate><title>Therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats</title><author>Huang, J F ; Zhan, T ; Yu, X L ; He, Q A ; Huang, W J ; Lin, L Z ; Du, Y T ; Pan, Y T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-8a6b03229e758934746dfd2a6f8dc0c1faad5887fb2e71e2e586afdc3da86c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Cellulose - pharmacology</topic><topic>Cellulose - therapeutic use</topic><topic>Cholesterol - blood</topic><topic>Disease Models, Animal</topic><topic>Fatty Liver - blood</topic><topic>Fatty Liver - drug therapy</topic><topic>Lipid Metabolism - drug effects</topic><topic>Liver - drug effects</topic><topic>Male</topic><topic>Pleurotus</topic><topic>Pleurotus eryngii</topic><topic>Rats</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, J F</creatorcontrib><creatorcontrib>Zhan, T</creatorcontrib><creatorcontrib>Yu, X L</creatorcontrib><creatorcontrib>He, Q A</creatorcontrib><creatorcontrib>Huang, W J</creatorcontrib><creatorcontrib>Lin, L Z</creatorcontrib><creatorcontrib>Du, Y T</creatorcontrib><creatorcontrib>Pan, Y T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Genetics and molecular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, J F</au><au>Zhan, T</au><au>Yu, X L</au><au>He, Q A</au><au>Huang, W J</au><au>Lin, L Z</au><au>Du, Y T</au><au>Pan, Y T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats</atitle><jtitle>Genetics and molecular research</jtitle><addtitle>Genet Mol Res</addtitle><date>2016-02-26</date><risdate>2016</risdate><volume>15</volume><issue>1</issue><spage>15017805</spage><epage>15017805</epage><pages>15017805-15017805</pages><issn>1676-5680</issn><eissn>1676-5680</eissn><abstract>The aim of this study was to explore the therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats. Rats were fed high-fat fodder to establish a rat fatty liver model, and were then fed different concentrations of Pleurotus eryngii cellulose for six weeks. Lipitor was used as a positive control. Measured levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), and total triglyceride (TG); the activity of malondialdehyde (MDA), superoxide dismutase (SOD), hepatic lipase (HL), and lipoprotein lipase; and liver histopathological changes. Successfully established rat fatty liver model after feeding high-fat fodder for one week. A diet of P. eryngii cellulose for six weeks significantly reduced ALT, AST, TC, and TG levels in rat serum (P < 0.01); TC and AST levels in P. eryngii cellulose high-dose group and Lipitor group were not significantly different from those of the control (P > 0.05). SOD activity increased significantly, while MDA and HL activity decreased (P < 0.05); fatty degeneration and fat accumulation both decreased in hepatic tissue. Hepatic protection of P. eryngii cellulose showed dose-related effect. P. eryngii cellulose can affect lipid metabolism, having therapeutic effects on fatty liver in rats.</abstract><cop>Brazil</cop><pmid>26985922</pmid><doi>10.4238/gmr.15017805</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Cellulose - pharmacology Cellulose - therapeutic use Cholesterol - blood Disease Models, Animal Fatty Liver - blood Fatty Liver - drug therapy Lipid Metabolism - drug effects Liver - drug effects Male Pleurotus Pleurotus eryngii Rats Triglycerides - blood |
| title | Therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats |
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