Riboswitches: From living biosensors to novel targets of antibiotics

Riboswitches are generally located in 5′-UTR region of mRNAs and specifically bind small ligands. Following ligand binding, gene expression is controlled mostly by transcription termination, translation inhibition or mRNA degradation processes. More than 30 classes of known riboswitches have been id...

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Veröffentlicht in:	Gene 2016-11, Vol.592 (2), p.244-259
Hauptverfasser:	Mehdizadeh Aghdam, Elnaz, Hejazi, Mohammad Saeid, Barzegar, Abolfazl
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterials Biosensing Techniques - methods Biosensor Drug design Drug Discovery - methods Engineered riboswitches Humans Riboswitch Riboswitch - drug effects Riboswitch - genetics RNA
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