Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications

Background Loss of imprinting (LOI) of the insulin-like growth factor 2 (IGF2) is an early event in the development of colorectal cancer (CRC). Whether LOI of IGF2 denotes a molecular or clinical cancer subgroup is currently unknown. Methods Tumor biopsies and paired normal mucosa from 399 patients...

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Veröffentlicht in:	Journal of gastroenterology 2016-10, Vol.51 (10), p.971-984
Hauptverfasser:	Belharazem, Djeda, Magdeburg, Julia, Berton, Ann-Kristin, Beissbarth, Li, Sauer, Christian, Sticht, Carsten, Marx, Alexander, Hofheinz, Ralf, Post, Stefan, Kienle, Peter, Ströbel, Philipp
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Adult Aged Aged, 80 and over Antigens, CD - genetics BRCA2 Protein - genetics Carcinoma - enzymology Carcinoma - genetics Carcinoma - metabolism CDC2 Protein Kinase Cell Adhesion Molecules - genetics Cell Line, Tumor Colorectal cancer Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Surgery Cyclin-Dependent Kinases - genetics Development and progression Epigenesis, Genetic Female Gastroenterology Gene Expression Gene Expression Profiling Genotype GPI-Linked Proteins - genetics Health aspects Hepatology Humans Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Male Medicine Medicine & Public Health Microsatellite Instability Middle Aged Original Article—Alimentary Tract Polymorphism, Genetic Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins p21(ras) - genetics Receptors, Somatomedin - metabolism RNA-Binding Proteins - genetics Surgical Oncology Survival Rate Wnt Signaling Pathway - genetics Wnt-5a Protein - genetics
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