The Association of Brain-Derived Neurotrophic Factor Gene Polymorphism with Obstructive Sleep Apnea Syndrome and Obesity
Background Obesity represents a major risk factor for Obstructive Sleep Apnea Syndrome (OSAS). Brain-derived neurotrophic factor (BDNF) affects the mechanisms that regulate weight, eating behavior, and metabolism. This project aims to investigate the possible association of BDNF gene polymorphism wi...
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| Veröffentlicht in: | Lung 2016-10, Vol.194 (5), p.839-846 |
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| creator | Yüksekkaya, Mehmet Tutar, Nuri Büyükoğlan, Hakan Dündar, Munis Yılmaz, İnsu Gülmez, İnci Oymak, Fatma Sema Balta, Burhan Korkmaz, Keziban Demir, Ramazan |
| description | Background
Obesity represents a major risk factor for Obstructive Sleep Apnea Syndrome (OSAS). Brain-derived neurotrophic factor (BDNF) affects the mechanisms that regulate weight, eating behavior, and metabolism. This project aims to investigate the possible association of BDNF gene polymorphism with obesity and OSAS, and to contribute knowledge to the understanding of the pathophysiology of OSAS.
Methods
The subjects included in this study were selected among the individuals who were hospitalized in the Erciyes University Medical School Chest Diseases Sleep Medicine Laboratory. Subjects were divided into four groups based on the presence of OSAS and/or obesity. Group 1 included OSAS+ obesity+ patients, Group 2 included OSAS+ obesity− patients, Group 3 included OSAS− obesity+ patients, and Group 4 included OSAS− obesity− patients. The targeted patient number per each study group was 45, but only 32 patients could be enrolled into Group 3.
Results
Out of a total number of 167 subjects, 117 (70.1 %) had
BDNF 196G/G
, 48 (28.7 %) had
BDNF 196G/A
, and 2 (1.2 %) had
BDNF 196A/A
genotype. Of 48 subjects having
BDNF 196G/A
genotype, 32 (66.6 %) were obese, and 16 (33.3 %) were non-obese. Out of 90 subjects with OSAS, 64 (71.1 %) had
BDNF 196G/G
, and 25 (27.8 %) had
BDNF 196G/A
genotype. Out of 77 subjects without OSAS,
BDNF 196G/G,
and
BDNF 196G/A
genotypes were detected in 53 (68.8 %) and 23 (29.9 %) subjects, respectively. A statistically significant difference was demonstrated between the four study groups in terms of
BDNF rs6265
polymorphism (
p
= 0.013). This difference was attributed to OSAS+ obesity− Group, in which
BDNF 196G/G
genotype was more common and
BDNF 196G/A
polymorphism was less common than the patients in other groups.
Conclusion
In conclusion,
BDNF 196G/A
genotype was found to be more frequent among obese patients compared to the non-obese individuals, but it was not significantly related to OSAS in the present study.
BDNF196G/G
genotype was more common and
BDNF 196G/A
polymorphism was less common among OSAS+ obesity- subjects compared to the other study groups. |
| doi_str_mv | 10.1007/s00408-016-9894-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1827917368</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A470739142</galeid><sourcerecordid>A470739142</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-1a88ecad2ab3242822efe011b4543a052c5700e5e22db6640fd4c4ff7c8d70433</originalsourceid><addsrcrecordid>eNqNkl9rFDEUxQdR7Fr9AL5IQBBfpt78mcns49raKhQrtD6HTObObspMMiYz2u2nN8PW0soKkofAze8cuCcny15TOKIA8kMEEFDlQMt8WS1FfvskW1DBWU5lAU-zBXBBc5aYg-xFjNcAVJa0eJ4dMEnLsuRskd1cbZCsYvTG6tF6R3xLPgZtXX6Cwf7EhnzFKfgx-GFjDTnVZvSBnKFD8s13296HNI89-WXHDbmo4xgmMyYduewQB7IaHGpyuXVN8D0S7ZoEYbTj9mX2rNVdxFd392H2_fTT1fHn_Pzi7Mvx6jw3haBjTnVVodEN0zVnglWMYYtAaS0KwTUUzBQSAAtkrKnLUkDbCCPaVpqqkSA4P8ze73yH4H9MGEfV22iw67RDP0VFKyaXVPKy-h-UA6eClQl9-xd67afg0iIzlSLnkOB7aq07VNa1KUdtZlO1EhIkXyazROV7qHWKOOjOO2xtGj_ij_bw6TTYW7NX8O6BYIO6GzfRd9P83_ExSHegCT7GgK0agu112CoKam6c2jVOpcapuXHqNmne3CUx1T0294o_FUsA2wExPbk1hgdR_dP1Nz6n3kA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1822043082</pqid></control><display><type>article</type><title>The Association of Brain-Derived Neurotrophic Factor Gene Polymorphism with Obstructive Sleep Apnea Syndrome and Obesity</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Yüksekkaya, Mehmet ; Tutar, Nuri ; Büyükoğlan, Hakan ; Dündar, Munis ; Yılmaz, İnsu ; Gülmez, İnci ; Oymak, Fatma Sema ; Balta, Burhan ; Korkmaz, Keziban ; Demir, Ramazan</creator><creatorcontrib>Yüksekkaya, Mehmet ; Tutar, Nuri ; Büyükoğlan, Hakan ; Dündar, Munis ; Yılmaz, İnsu ; Gülmez, İnci ; Oymak, Fatma Sema ; Balta, Burhan ; Korkmaz, Keziban ; Demir, Ramazan</creatorcontrib><description>Background
Obesity represents a major risk factor for Obstructive Sleep Apnea Syndrome (OSAS). Brain-derived neurotrophic factor (BDNF) affects the mechanisms that regulate weight, eating behavior, and metabolism. This project aims to investigate the possible association of BDNF gene polymorphism with obesity and OSAS, and to contribute knowledge to the understanding of the pathophysiology of OSAS.
Methods
The subjects included in this study were selected among the individuals who were hospitalized in the Erciyes University Medical School Chest Diseases Sleep Medicine Laboratory. Subjects were divided into four groups based on the presence of OSAS and/or obesity. Group 1 included OSAS+ obesity+ patients, Group 2 included OSAS+ obesity− patients, Group 3 included OSAS− obesity+ patients, and Group 4 included OSAS− obesity− patients. The targeted patient number per each study group was 45, but only 32 patients could be enrolled into Group 3.
Results
Out of a total number of 167 subjects, 117 (70.1 %) had
BDNF 196G/G
, 48 (28.7 %) had
BDNF 196G/A
, and 2 (1.2 %) had
BDNF 196A/A
genotype. Of 48 subjects having
BDNF 196G/A
genotype, 32 (66.6 %) were obese, and 16 (33.3 %) were non-obese. Out of 90 subjects with OSAS, 64 (71.1 %) had
BDNF 196G/G
, and 25 (27.8 %) had
BDNF 196G/A
genotype. Out of 77 subjects without OSAS,
BDNF 196G/G,
and
BDNF 196G/A
genotypes were detected in 53 (68.8 %) and 23 (29.9 %) subjects, respectively. A statistically significant difference was demonstrated between the four study groups in terms of
BDNF rs6265
polymorphism (
p
= 0.013). This difference was attributed to OSAS+ obesity− Group, in which
BDNF 196G/G
genotype was more common and
BDNF 196G/A
polymorphism was less common than the patients in other groups.
Conclusion
In conclusion,
BDNF 196G/A
genotype was found to be more frequent among obese patients compared to the non-obese individuals, but it was not significantly related to OSAS in the present study.
BDNF196G/G
genotype was more common and
BDNF 196G/A
polymorphism was less common among OSAS+ obesity- subjects compared to the other study groups.</description><identifier>ISSN: 0341-2040</identifier><identifier>EISSN: 1432-1750</identifier><identifier>DOI: 10.1007/s00408-016-9894-z</identifier><identifier>PMID: 27166632</identifier><identifier>CODEN: LUNGD9</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Body Mass Index ; Brain ; Brain-Derived Neurotrophic Factor - genetics ; Cholesterol, HDL - blood ; Cholesterol, LDL ; Female ; Genes ; Genotype ; Genotype & phenotype ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Obesity ; Obesity - blood ; Obesity - complications ; Obesity - genetics ; Pneumology/Respiratory System ; Polymorphism ; Polymorphism, Single Nucleotide ; Polysomnography ; Severity of Illness Index ; Sleep apnea ; Sleep Apnea, Obstructive - blood ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - genetics ; Triglycerides - blood ; Waist Circumference ; Waist-Hip Ratio</subject><ispartof>Lung, 2016-10, Vol.194 (5), p.839-846</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>COPYRIGHT 2016 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-1a88ecad2ab3242822efe011b4543a052c5700e5e22db6640fd4c4ff7c8d70433</citedby><cites>FETCH-LOGICAL-c541t-1a88ecad2ab3242822efe011b4543a052c5700e5e22db6640fd4c4ff7c8d70433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00408-016-9894-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00408-016-9894-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27166632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yüksekkaya, Mehmet</creatorcontrib><creatorcontrib>Tutar, Nuri</creatorcontrib><creatorcontrib>Büyükoğlan, Hakan</creatorcontrib><creatorcontrib>Dündar, Munis</creatorcontrib><creatorcontrib>Yılmaz, İnsu</creatorcontrib><creatorcontrib>Gülmez, İnci</creatorcontrib><creatorcontrib>Oymak, Fatma Sema</creatorcontrib><creatorcontrib>Balta, Burhan</creatorcontrib><creatorcontrib>Korkmaz, Keziban</creatorcontrib><creatorcontrib>Demir, Ramazan</creatorcontrib><title>The Association of Brain-Derived Neurotrophic Factor Gene Polymorphism with Obstructive Sleep Apnea Syndrome and Obesity</title><title>Lung</title><addtitle>Lung</addtitle><addtitle>Lung</addtitle><description>Background
Obesity represents a major risk factor for Obstructive Sleep Apnea Syndrome (OSAS). Brain-derived neurotrophic factor (BDNF) affects the mechanisms that regulate weight, eating behavior, and metabolism. This project aims to investigate the possible association of BDNF gene polymorphism with obesity and OSAS, and to contribute knowledge to the understanding of the pathophysiology of OSAS.
Methods
The subjects included in this study were selected among the individuals who were hospitalized in the Erciyes University Medical School Chest Diseases Sleep Medicine Laboratory. Subjects were divided into four groups based on the presence of OSAS and/or obesity. Group 1 included OSAS+ obesity+ patients, Group 2 included OSAS+ obesity− patients, Group 3 included OSAS− obesity+ patients, and Group 4 included OSAS− obesity− patients. The targeted patient number per each study group was 45, but only 32 patients could be enrolled into Group 3.
Results
Out of a total number of 167 subjects, 117 (70.1 %) had
BDNF 196G/G
, 48 (28.7 %) had
BDNF 196G/A
, and 2 (1.2 %) had
BDNF 196A/A
genotype. Of 48 subjects having
BDNF 196G/A
genotype, 32 (66.6 %) were obese, and 16 (33.3 %) were non-obese. Out of 90 subjects with OSAS, 64 (71.1 %) had
BDNF 196G/G
, and 25 (27.8 %) had
BDNF 196G/A
genotype. Out of 77 subjects without OSAS,
BDNF 196G/G,
and
BDNF 196G/A
genotypes were detected in 53 (68.8 %) and 23 (29.9 %) subjects, respectively. A statistically significant difference was demonstrated between the four study groups in terms of
BDNF rs6265
polymorphism (
p
= 0.013). This difference was attributed to OSAS+ obesity− Group, in which
BDNF 196G/G
genotype was more common and
BDNF 196G/A
polymorphism was less common than the patients in other groups.
Conclusion
In conclusion,
BDNF 196G/A
genotype was found to be more frequent among obese patients compared to the non-obese individuals, but it was not significantly related to OSAS in the present study.
BDNF196G/G
genotype was more common and
BDNF 196G/A
polymorphism was less common among OSAS+ obesity- subjects compared to the other study groups.</description><subject>Adult</subject><subject>Body Mass Index</subject><subject>Brain</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL</subject><subject>Female</subject><subject>Genes</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - genetics</subject><subject>Pneumology/Respiratory System</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Polysomnography</subject><subject>Severity of Illness Index</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - blood</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - genetics</subject><subject>Triglycerides - blood</subject><subject>Waist Circumference</subject><subject>Waist-Hip Ratio</subject><issn>0341-2040</issn><issn>1432-1750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkl9rFDEUxQdR7Fr9AL5IQBBfpt78mcns49raKhQrtD6HTObObspMMiYz2u2nN8PW0soKkofAze8cuCcny15TOKIA8kMEEFDlQMt8WS1FfvskW1DBWU5lAU-zBXBBc5aYg-xFjNcAVJa0eJ4dMEnLsuRskd1cbZCsYvTG6tF6R3xLPgZtXX6Cwf7EhnzFKfgx-GFjDTnVZvSBnKFD8s13296HNI89-WXHDbmo4xgmMyYduewQB7IaHGpyuXVN8D0S7ZoEYbTj9mX2rNVdxFd392H2_fTT1fHn_Pzi7Mvx6jw3haBjTnVVodEN0zVnglWMYYtAaS0KwTUUzBQSAAtkrKnLUkDbCCPaVpqqkSA4P8ze73yH4H9MGEfV22iw67RDP0VFKyaXVPKy-h-UA6eClQl9-xd67afg0iIzlSLnkOB7aq07VNa1KUdtZlO1EhIkXyazROV7qHWKOOjOO2xtGj_ij_bw6TTYW7NX8O6BYIO6GzfRd9P83_ExSHegCT7GgK0agu112CoKam6c2jVOpcapuXHqNmne3CUx1T0294o_FUsA2wExPbk1hgdR_dP1Nz6n3kA</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Yüksekkaya, Mehmet</creator><creator>Tutar, Nuri</creator><creator>Büyükoğlan, Hakan</creator><creator>Dündar, Munis</creator><creator>Yılmaz, İnsu</creator><creator>Gülmez, İnci</creator><creator>Oymak, Fatma Sema</creator><creator>Balta, Burhan</creator><creator>Korkmaz, Keziban</creator><creator>Demir, Ramazan</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>RC3</scope></search><sort><creationdate>20161001</creationdate><title>The Association of Brain-Derived Neurotrophic Factor Gene Polymorphism with Obstructive Sleep Apnea Syndrome and Obesity</title><author>Yüksekkaya, Mehmet ; Tutar, Nuri ; Büyükoğlan, Hakan ; Dündar, Munis ; Yılmaz, İnsu ; Gülmez, İnci ; Oymak, Fatma Sema ; Balta, Burhan ; Korkmaz, Keziban ; Demir, Ramazan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-1a88ecad2ab3242822efe011b4543a052c5700e5e22db6640fd4c4ff7c8d70433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Body Mass Index</topic><topic>Brain</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL</topic><topic>Female</topic><topic>Genes</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Obesity - genetics</topic><topic>Pneumology/Respiratory System</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Polysomnography</topic><topic>Severity of Illness Index</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - blood</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - genetics</topic><topic>Triglycerides - blood</topic><topic>Waist Circumference</topic><topic>Waist-Hip Ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yüksekkaya, Mehmet</creatorcontrib><creatorcontrib>Tutar, Nuri</creatorcontrib><creatorcontrib>Büyükoğlan, Hakan</creatorcontrib><creatorcontrib>Dündar, Munis</creatorcontrib><creatorcontrib>Yılmaz, İnsu</creatorcontrib><creatorcontrib>Gülmez, İnci</creatorcontrib><creatorcontrib>Oymak, Fatma Sema</creatorcontrib><creatorcontrib>Balta, Burhan</creatorcontrib><creatorcontrib>Korkmaz, Keziban</creatorcontrib><creatorcontrib>Demir, Ramazan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Genetics Abstracts</collection><jtitle>Lung</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yüksekkaya, Mehmet</au><au>Tutar, Nuri</au><au>Büyükoğlan, Hakan</au><au>Dündar, Munis</au><au>Yılmaz, İnsu</au><au>Gülmez, İnci</au><au>Oymak, Fatma Sema</au><au>Balta, Burhan</au><au>Korkmaz, Keziban</au><au>Demir, Ramazan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Association of Brain-Derived Neurotrophic Factor Gene Polymorphism with Obstructive Sleep Apnea Syndrome and Obesity</atitle><jtitle>Lung</jtitle><stitle>Lung</stitle><addtitle>Lung</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>194</volume><issue>5</issue><spage>839</spage><epage>846</epage><pages>839-846</pages><issn>0341-2040</issn><eissn>1432-1750</eissn><coden>LUNGD9</coden><abstract>Background
Obesity represents a major risk factor for Obstructive Sleep Apnea Syndrome (OSAS). Brain-derived neurotrophic factor (BDNF) affects the mechanisms that regulate weight, eating behavior, and metabolism. This project aims to investigate the possible association of BDNF gene polymorphism with obesity and OSAS, and to contribute knowledge to the understanding of the pathophysiology of OSAS.
Methods
The subjects included in this study were selected among the individuals who were hospitalized in the Erciyes University Medical School Chest Diseases Sleep Medicine Laboratory. Subjects were divided into four groups based on the presence of OSAS and/or obesity. Group 1 included OSAS+ obesity+ patients, Group 2 included OSAS+ obesity− patients, Group 3 included OSAS− obesity+ patients, and Group 4 included OSAS− obesity− patients. The targeted patient number per each study group was 45, but only 32 patients could be enrolled into Group 3.
Results
Out of a total number of 167 subjects, 117 (70.1 %) had
BDNF 196G/G
, 48 (28.7 %) had
BDNF 196G/A
, and 2 (1.2 %) had
BDNF 196A/A
genotype. Of 48 subjects having
BDNF 196G/A
genotype, 32 (66.6 %) were obese, and 16 (33.3 %) were non-obese. Out of 90 subjects with OSAS, 64 (71.1 %) had
BDNF 196G/G
, and 25 (27.8 %) had
BDNF 196G/A
genotype. Out of 77 subjects without OSAS,
BDNF 196G/G,
and
BDNF 196G/A
genotypes were detected in 53 (68.8 %) and 23 (29.9 %) subjects, respectively. A statistically significant difference was demonstrated between the four study groups in terms of
BDNF rs6265
polymorphism (
p
= 0.013). This difference was attributed to OSAS+ obesity− Group, in which
BDNF 196G/G
genotype was more common and
BDNF 196G/A
polymorphism was less common than the patients in other groups.
Conclusion
In conclusion,
BDNF 196G/A
genotype was found to be more frequent among obese patients compared to the non-obese individuals, but it was not significantly related to OSAS in the present study.
BDNF196G/G
genotype was more common and
BDNF 196G/A
polymorphism was less common among OSAS+ obesity- subjects compared to the other study groups.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27166632</pmid><doi>10.1007/s00408-016-9894-z</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0341-2040 |
| ispartof | Lung, 2016-10, Vol.194 (5), p.839-846 |
| issn | 0341-2040 1432-1750 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1827917368 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Body Mass Index Brain Brain-Derived Neurotrophic Factor - genetics Cholesterol, HDL - blood Cholesterol, LDL Female Genes Genotype Genotype & phenotype Humans Male Medicine Medicine & Public Health Middle Aged Obesity Obesity - blood Obesity - complications Obesity - genetics Pneumology/Respiratory System Polymorphism Polymorphism, Single Nucleotide Polysomnography Severity of Illness Index Sleep apnea Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - genetics Triglycerides - blood Waist Circumference Waist-Hip Ratio |
| title | The Association of Brain-Derived Neurotrophic Factor Gene Polymorphism with Obstructive Sleep Apnea Syndrome and Obesity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T20%3A56%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Association%20of%20Brain-Derived%20Neurotrophic%20Factor%20Gene%20Polymorphism%20with%20Obstructive%20Sleep%20Apnea%20Syndrome%20and%20Obesity&rft.jtitle=Lung&rft.au=Y%C3%BCksekkaya,%20Mehmet&rft.date=2016-10-01&rft.volume=194&rft.issue=5&rft.spage=839&rft.epage=846&rft.pages=839-846&rft.issn=0341-2040&rft.eissn=1432-1750&rft.coden=LUNGD9&rft_id=info:doi/10.1007/s00408-016-9894-z&rft_dat=%3Cgale_proqu%3EA470739142%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1822043082&rft_id=info:pmid/27166632&rft_galeid=A470739142&rfr_iscdi=true |