Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation

Current therapies for hepatitis B virus (HBV) cannot completely eliminate the HBV genome because of the stable population of covalently closed circular DNA (cccDNA) and so on. FIT-039, which is a cyclin-dependent kinase (CDK) 9 inhibitor, is known to suppress the replication of several DNA viruses i...

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Veröffentlicht in:	Antiviral research 2016-09, Vol.133, p.156-164
Hauptverfasser:	Tanaka, Tomohisa, Okuyama-Dobashi, Kaori, Murakami, Shuko, Chen, Wenjia, Okamoto, Toru, Ueda, Keiji, Hosoya, Takamitsu, Matsuura, Yoshiharu, Ryo, Akihide, Tanaka, Yasuhito, Hagiwara, Masatoshi, Moriishi, Kohji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Antiviral Agents - chemistry Antiviral Agents - pharmacology cccDNA CDK9 inhibitor Cell Line Cyclin-Dependent Kinase 9 - antagonists & inhibitors Disease Models, Animal DNA, Circular DNA, Viral HBV Hep G2 Cells Hepatitis B Hepatitis B - drug therapy Hepatitis B - virology Hepatitis B virus Hepatitis B virus - drug effects Human adenovirus Human papillomavirus Humans Mice Pyridines - chemistry Pyridines - pharmacology Replication Virus Replication - drug effects
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