Adverse drug reactions of systemic antihistamines in children in the Netherlands
BackgroundAntihistamines are used for the treatment of allergic rhinitis, allergic conjunctivitis, chronic spontaneous urticaria and atopic eczema.ObjectiveTo study the reports of adverse drug reactions (ADRs) in children using antihistamines to provide prescribers with an overview of the possible t...
Gespeichert in:
| Veröffentlicht in: | Archives of disease in childhood 2016-10, Vol.101 (10), p.968-970 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 970 |
|---|---|
| container_issue | 10 |
| container_start_page | 968 |
| container_title | Archives of disease in childhood |
| container_volume | 101 |
| creator | de Vries, Tjalling W van Hunsel, Florence |
| description | BackgroundAntihistamines are used for the treatment of allergic rhinitis, allergic conjunctivitis, chronic spontaneous urticaria and atopic eczema.ObjectiveTo study the reports of adverse drug reactions (ADRs) in children using antihistamines to provide prescribers with an overview of the possible toxicity.DesignWe studied ADRs in children reported to the Netherlands Pharmacovigilance Centre Lareb in the years 1991–2014, assessed the Naranjo score and, when possible, computed the reporting OR.ResultsSerious ADRs included one death (malignant neuroleptic syndrome), cardiac arrhythmia (one case) and convulsions (three cases). Skin eruptions, headache and somnolence were the most frequently reported ADRs. Aggression and agitation were also reported.ConclusionsToxicity can occur with second-generation antihistamines. The main toxicity relates to skin eruptions and central nervous system problems. |
| doi_str_mv | 10.1136/archdischild-2015-310315 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1827915790</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A471113924</galeid><sourcerecordid>A471113924</sourcerecordid><originalsourceid>FETCH-LOGICAL-b522t-f6f04dc9e6007f120fd2c8294e530afdf9adbaa5d5d656547685ae604b205e873</originalsourceid><addsrcrecordid>eNqNkE1P3DAQhi1UBAvlLyAfuQTGjp04x9WKQiVUeqBny7HHu0b5ANtblX9fL6FVj72MR9YzM68eQiiDa8bq5sZEu3Mh2V0YXMWByapmUDN5RFZMNKp8CfGJrACgrjql1Ck5S-kZgHGl6hNyylvomBJqRb6v3U-MCamL-y2NaGwO85To7Gl6SxnHYKmZctiFlM0YJkw0TPT9cMTp0Ocd0m9YahzM5NJncuzNkPDi4z0nP77cPm3uq4fHu6-b9UPVS85z5RsPwtkOG4DWMw7ecat4J1DWYLzznXG9MdJJ18hGirZR0hRY9BwkqrY-J1fL3pc4v-4xZT0WITiUEDjvk2aKtx2TbQcFrRZ0awbUYbLzlPFXtvMw4BZ1ibV51GvRsuK246LwauFtnFOK6PVLDKOJb5qBPvjX__rXB_968V9GLz9S7fsR3d_BP8ILUC9APz7__9rfN5aVWQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1827915790</pqid></control><display><type>article</type><title>Adverse drug reactions of systemic antihistamines in children in the Netherlands</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>de Vries, Tjalling W ; van Hunsel, Florence</creator><creatorcontrib>de Vries, Tjalling W ; van Hunsel, Florence</creatorcontrib><description>BackgroundAntihistamines are used for the treatment of allergic rhinitis, allergic conjunctivitis, chronic spontaneous urticaria and atopic eczema.ObjectiveTo study the reports of adverse drug reactions (ADRs) in children using antihistamines to provide prescribers with an overview of the possible toxicity.DesignWe studied ADRs in children reported to the Netherlands Pharmacovigilance Centre Lareb in the years 1991–2014, assessed the Naranjo score and, when possible, computed the reporting OR.ResultsSerious ADRs included one death (malignant neuroleptic syndrome), cardiac arrhythmia (one case) and convulsions (three cases). Skin eruptions, headache and somnolence were the most frequently reported ADRs. Aggression and agitation were also reported.ConclusionsToxicity can occur with second-generation antihistamines. The main toxicity relates to skin eruptions and central nervous system problems.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/archdischild-2015-310315</identifier><identifier>PMID: 27091848</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>Adolescent ; Adverse and side effects ; Adverse drug reactions ; Aggression - drug effects ; Allergic rhinitis ; Antihistamines ; Atopic dermatitis ; Care and treatment ; Child ; Child, Preschool ; Children ; Conjunctivitis ; Diagnosis ; Drug Eruptions - etiology ; Drugs ; Female ; Hay-fever ; Headache Disorders - chemically induced ; Health aspects ; Histamine Antagonists - adverse effects ; Hives (Disease) ; Humans ; Hyperkinesis - chemically induced ; Infant ; Male ; Netherlands ; Psychomotor Agitation - etiology ; Retrospective Studies ; Sleep Initiation and Maintenance Disorders - chemically induced ; Tachycardia - chemically induced ; Urticaria</subject><ispartof>Archives of disease in childhood, 2016-10, Vol.101 (10), p.968-970</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b522t-f6f04dc9e6007f120fd2c8294e530afdf9adbaa5d5d656547685ae604b205e873</citedby><cites>FETCH-LOGICAL-b522t-f6f04dc9e6007f120fd2c8294e530afdf9adbaa5d5d656547685ae604b205e873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://adc.bmj.com/content/101/10/968.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://adc.bmj.com/content/101/10/968.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77343,77374</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27091848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Vries, Tjalling W</creatorcontrib><creatorcontrib>van Hunsel, Florence</creatorcontrib><title>Adverse drug reactions of systemic antihistamines in children in the Netherlands</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>BackgroundAntihistamines are used for the treatment of allergic rhinitis, allergic conjunctivitis, chronic spontaneous urticaria and atopic eczema.ObjectiveTo study the reports of adverse drug reactions (ADRs) in children using antihistamines to provide prescribers with an overview of the possible toxicity.DesignWe studied ADRs in children reported to the Netherlands Pharmacovigilance Centre Lareb in the years 1991–2014, assessed the Naranjo score and, when possible, computed the reporting OR.ResultsSerious ADRs included one death (malignant neuroleptic syndrome), cardiac arrhythmia (one case) and convulsions (three cases). Skin eruptions, headache and somnolence were the most frequently reported ADRs. Aggression and agitation were also reported.ConclusionsToxicity can occur with second-generation antihistamines. The main toxicity relates to skin eruptions and central nervous system problems.</description><subject>Adolescent</subject><subject>Adverse and side effects</subject><subject>Adverse drug reactions</subject><subject>Aggression - drug effects</subject><subject>Allergic rhinitis</subject><subject>Antihistamines</subject><subject>Atopic dermatitis</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Conjunctivitis</subject><subject>Diagnosis</subject><subject>Drug Eruptions - etiology</subject><subject>Drugs</subject><subject>Female</subject><subject>Hay-fever</subject><subject>Headache Disorders - chemically induced</subject><subject>Health aspects</subject><subject>Histamine Antagonists - adverse effects</subject><subject>Hives (Disease)</subject><subject>Humans</subject><subject>Hyperkinesis - chemically induced</subject><subject>Infant</subject><subject>Male</subject><subject>Netherlands</subject><subject>Psychomotor Agitation - etiology</subject><subject>Retrospective Studies</subject><subject>Sleep Initiation and Maintenance Disorders - chemically induced</subject><subject>Tachycardia - chemically induced</subject><subject>Urticaria</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P3DAQhi1UBAvlLyAfuQTGjp04x9WKQiVUeqBny7HHu0b5ANtblX9fL6FVj72MR9YzM68eQiiDa8bq5sZEu3Mh2V0YXMWByapmUDN5RFZMNKp8CfGJrACgrjql1Ck5S-kZgHGl6hNyylvomBJqRb6v3U-MCamL-y2NaGwO85To7Gl6SxnHYKmZctiFlM0YJkw0TPT9cMTp0Ocd0m9YahzM5NJncuzNkPDi4z0nP77cPm3uq4fHu6-b9UPVS85z5RsPwtkOG4DWMw7ecat4J1DWYLzznXG9MdJJ18hGirZR0hRY9BwkqrY-J1fL3pc4v-4xZT0WITiUEDjvk2aKtx2TbQcFrRZ0awbUYbLzlPFXtvMw4BZ1ibV51GvRsuK246LwauFtnFOK6PVLDKOJb5qBPvjX__rXB_968V9GLz9S7fsR3d_BP8ILUC9APz7__9rfN5aVWQ</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>de Vries, Tjalling W</creator><creator>van Hunsel, Florence</creator><general>BMJ Publishing Group Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20161001</creationdate><title>Adverse drug reactions of systemic antihistamines in children in the Netherlands</title><author>de Vries, Tjalling W ; van Hunsel, Florence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b522t-f6f04dc9e6007f120fd2c8294e530afdf9adbaa5d5d656547685ae604b205e873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adverse and side effects</topic><topic>Adverse drug reactions</topic><topic>Aggression - drug effects</topic><topic>Allergic rhinitis</topic><topic>Antihistamines</topic><topic>Atopic dermatitis</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Conjunctivitis</topic><topic>Diagnosis</topic><topic>Drug Eruptions - etiology</topic><topic>Drugs</topic><topic>Female</topic><topic>Hay-fever</topic><topic>Headache Disorders - chemically induced</topic><topic>Health aspects</topic><topic>Histamine Antagonists - adverse effects</topic><topic>Hives (Disease)</topic><topic>Humans</topic><topic>Hyperkinesis - chemically induced</topic><topic>Infant</topic><topic>Male</topic><topic>Netherlands</topic><topic>Psychomotor Agitation - etiology</topic><topic>Retrospective Studies</topic><topic>Sleep Initiation and Maintenance Disorders - chemically induced</topic><topic>Tachycardia - chemically induced</topic><topic>Urticaria</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Vries, Tjalling W</creatorcontrib><creatorcontrib>van Hunsel, Florence</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Vries, Tjalling W</au><au>van Hunsel, Florence</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse drug reactions of systemic antihistamines in children in the Netherlands</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>101</volume><issue>10</issue><spage>968</spage><epage>970</epage><pages>968-970</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><abstract>BackgroundAntihistamines are used for the treatment of allergic rhinitis, allergic conjunctivitis, chronic spontaneous urticaria and atopic eczema.ObjectiveTo study the reports of adverse drug reactions (ADRs) in children using antihistamines to provide prescribers with an overview of the possible toxicity.DesignWe studied ADRs in children reported to the Netherlands Pharmacovigilance Centre Lareb in the years 1991–2014, assessed the Naranjo score and, when possible, computed the reporting OR.ResultsSerious ADRs included one death (malignant neuroleptic syndrome), cardiac arrhythmia (one case) and convulsions (three cases). Skin eruptions, headache and somnolence were the most frequently reported ADRs. Aggression and agitation were also reported.ConclusionsToxicity can occur with second-generation antihistamines. The main toxicity relates to skin eruptions and central nervous system problems.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>27091848</pmid><doi>10.1136/archdischild-2015-310315</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-9888 |
| ispartof | Archives of disease in childhood, 2016-10, Vol.101 (10), p.968-970 |
| issn | 0003-9888 1468-2044 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1827915790 |
| source | MEDLINE; BMJ Journals - NESLi2 |
| subjects | Adolescent Adverse and side effects Adverse drug reactions Aggression - drug effects Allergic rhinitis Antihistamines Atopic dermatitis Care and treatment Child Child, Preschool Children Conjunctivitis Diagnosis Drug Eruptions - etiology Drugs Female Hay-fever Headache Disorders - chemically induced Health aspects Histamine Antagonists - adverse effects Hives (Disease) Humans Hyperkinesis - chemically induced Infant Male Netherlands Psychomotor Agitation - etiology Retrospective Studies Sleep Initiation and Maintenance Disorders - chemically induced Tachycardia - chemically induced Urticaria |
| title | Adverse drug reactions of systemic antihistamines in children in the Netherlands |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T06%3A16%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adverse%20drug%20reactions%20of%20systemic%20antihistamines%20in%20children%20in%20the%20Netherlands&rft.jtitle=Archives%20of%20disease%20in%20childhood&rft.au=de%20Vries,%20Tjalling%20W&rft.date=2016-10-01&rft.volume=101&rft.issue=10&rft.spage=968&rft.epage=970&rft.pages=968-970&rft.issn=0003-9888&rft.eissn=1468-2044&rft_id=info:doi/10.1136/archdischild-2015-310315&rft_dat=%3Cgale_proqu%3EA471113924%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1827915790&rft_id=info:pmid/27091848&rft_galeid=A471113924&rfr_iscdi=true |