Pap-tests with non-hyperchromatic dyskariosis are often associated with squamous intraepithelial lesions of the cervix uteri with eosinophilic features
Background Squamous intraepithelial lesions of the cervix uteri with eosinophilic features (eosinophilic dysplasia, ED) are a peculiar type of dysplasia with metaplastic phenotype which was described in histological specimens. The cytological features of these lesions have not been studied yet. Meth...
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| Veröffentlicht in: | Diagnostic cytopathology 2016-10, Vol.44 (10), p.783-786 |
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| creator | Bellisano, Giulia Ambrosini-Spaltro, Andrea Faa, Gavino Ravarino, Alberto Piccin, Andrea Peer, Irmgard Kasal, Armin Vittadello, Fabio Negri, Giovanni |
| description | Background
Squamous intraepithelial lesions of the cervix uteri with eosinophilic features (eosinophilic dysplasia, ED) are a peculiar type of dysplasia with metaplastic phenotype which was described in histological specimens. The cytological features of these lesions have not been studied yet.
Methods
Histological samples from 66 women with features of ED and positive p16INK4a staining were included in the study. Within the previous year, all women had at least one pap‐test, whose features were recorded and compared with 31 control samples with high‐grade dysplasia of usual type.
Results
The previous pap‐test showed high‐grade dysplastic cells with non‐hyperchromatic nuclei in 56/66 (84.8%) cases and metaplastic features in 60/66 (90.9%) cases. Conversely, the dysplastic cells of the usual lesions showed non‐hyperchromatic nuclei in 6/31 (19.4%) and metaplastic features in 4/31 (12.9%) cases. Statistical analysis showed significant differences in distribution of the non‐hyperchromatic nuclei (P |
| doi_str_mv | 10.1002/dc.23532 |
| format | Article |
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Squamous intraepithelial lesions of the cervix uteri with eosinophilic features (eosinophilic dysplasia, ED) are a peculiar type of dysplasia with metaplastic phenotype which was described in histological specimens. The cytological features of these lesions have not been studied yet.
Methods
Histological samples from 66 women with features of ED and positive p16INK4a staining were included in the study. Within the previous year, all women had at least one pap‐test, whose features were recorded and compared with 31 control samples with high‐grade dysplasia of usual type.
Results
The previous pap‐test showed high‐grade dysplastic cells with non‐hyperchromatic nuclei in 56/66 (84.8%) cases and metaplastic features in 60/66 (90.9%) cases. Conversely, the dysplastic cells of the usual lesions showed non‐hyperchromatic nuclei in 6/31 (19.4%) and metaplastic features in 4/31 (12.9%) cases. Statistical analysis showed significant differences in distribution of the non‐hyperchromatic nuclei (P < 0.001), metaplastic features (P < 0.001), presence of both non‐hyperchromatic nuclei and metaplastic features (P < 0.001) and usual dysplastic features (P < 0.001) among the study and control groups.
Conclusions
A high‐grade squamous intraepithelial lesion with non‐hyperchromatic nuclei or metaplastic features is often found in the pap‐test previous to the histological diagnosis of ED and may represent the cytologic correlate of this particular type of dysplasia. Diagn. Cytopathol. 2016;44:783–786. © 2016 Wiley Periodicals, Inc.</description><identifier>ISSN: 8755-1039</identifier><identifier>EISSN: 1097-0339</identifier><identifier>DOI: 10.1002/dc.23532</identifier><identifier>PMID: 27407066</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Case-Control Studies ; Cell Nucleus - pathology ; cervical cytology ; Chromatin - pathology ; CIN ; Eosinophils - pathology ; Female ; HSIL ; Humans ; Papanicolaou Test ; Squamous Intraepithelial Lesions of the Cervix - pathology</subject><ispartof>Diagnostic cytopathology, 2016-10, Vol.44 (10), p.783-786</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3812-2c919fb1c9023e296ed501345bd7fb053ac3ec66b8b778c9b0042cdb5219908f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdc.23532$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdc.23532$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27407066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bellisano, Giulia</creatorcontrib><creatorcontrib>Ambrosini-Spaltro, Andrea</creatorcontrib><creatorcontrib>Faa, Gavino</creatorcontrib><creatorcontrib>Ravarino, Alberto</creatorcontrib><creatorcontrib>Piccin, Andrea</creatorcontrib><creatorcontrib>Peer, Irmgard</creatorcontrib><creatorcontrib>Kasal, Armin</creatorcontrib><creatorcontrib>Vittadello, Fabio</creatorcontrib><creatorcontrib>Negri, Giovanni</creatorcontrib><title>Pap-tests with non-hyperchromatic dyskariosis are often associated with squamous intraepithelial lesions of the cervix uteri with eosinophilic features</title><title>Diagnostic cytopathology</title><addtitle>Diagn. Cytopathol</addtitle><description>Background
Squamous intraepithelial lesions of the cervix uteri with eosinophilic features (eosinophilic dysplasia, ED) are a peculiar type of dysplasia with metaplastic phenotype which was described in histological specimens. The cytological features of these lesions have not been studied yet.
Methods
Histological samples from 66 women with features of ED and positive p16INK4a staining were included in the study. Within the previous year, all women had at least one pap‐test, whose features were recorded and compared with 31 control samples with high‐grade dysplasia of usual type.
Results
The previous pap‐test showed high‐grade dysplastic cells with non‐hyperchromatic nuclei in 56/66 (84.8%) cases and metaplastic features in 60/66 (90.9%) cases. Conversely, the dysplastic cells of the usual lesions showed non‐hyperchromatic nuclei in 6/31 (19.4%) and metaplastic features in 4/31 (12.9%) cases. Statistical analysis showed significant differences in distribution of the non‐hyperchromatic nuclei (P < 0.001), metaplastic features (P < 0.001), presence of both non‐hyperchromatic nuclei and metaplastic features (P < 0.001) and usual dysplastic features (P < 0.001) among the study and control groups.
Conclusions
A high‐grade squamous intraepithelial lesion with non‐hyperchromatic nuclei or metaplastic features is often found in the pap‐test previous to the histological diagnosis of ED and may represent the cytologic correlate of this particular type of dysplasia. Diagn. Cytopathol. 2016;44:783–786. © 2016 Wiley Periodicals, Inc.</description><subject>Case-Control Studies</subject><subject>Cell Nucleus - pathology</subject><subject>cervical cytology</subject><subject>Chromatin - pathology</subject><subject>CIN</subject><subject>Eosinophils - pathology</subject><subject>Female</subject><subject>HSIL</subject><subject>Humans</subject><subject>Papanicolaou Test</subject><subject>Squamous Intraepithelial Lesions of the Cervix - pathology</subject><issn>8755-1039</issn><issn>1097-0339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1rFDEUhoModq2Cv0AC3ngzNR-br0vZaist6oXiZchkzrBpZyfTJGO7v8S_a9bdVhAErwKH530OJy9CLyk5oYSwt50_YVxw9ggtKDGqIZybx2ihlRANJdwcoWc5XxFCDKPyKTpiakkUkXKBfn5xU1Mgl4xvQ1njMY7NejtB8usUN64Ej7ttvnYpxBwydglw7AuM2OUcfXAFun0w38xuE-eMw1iSg6nOYAhuwAPkEMdcY7iOsIf0I9zhuUAK-yRU8xindRjqsh5cmRPk5-hJ74YMLw7vMfr24f3X1Xlz-fns4-rdZeO5pqxh3lDTt9QbwjgwI6EThPKlaDvVt0Rw5zl4KVvdKqW9aQlZMt-1glFjiO75MXqz904p3sz1H-wmZA_D4Eao11iqmTKUEan-A9056_Id-vov9CrOaayH7CgtteZS_hH6FHNO0NsphY1LW0uJ3fVqO29_91rRVwfh3G6gewDvi6xAswduwwDbf4rs6epeeOBDLnD3wLt0beupStjvn84suzgXUlxQq_kvC2-8oA</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Bellisano, Giulia</creator><creator>Ambrosini-Spaltro, Andrea</creator><creator>Faa, Gavino</creator><creator>Ravarino, Alberto</creator><creator>Piccin, Andrea</creator><creator>Peer, Irmgard</creator><creator>Kasal, Armin</creator><creator>Vittadello, Fabio</creator><creator>Negri, Giovanni</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>201610</creationdate><title>Pap-tests with non-hyperchromatic dyskariosis are often associated with squamous intraepithelial lesions of the cervix uteri with eosinophilic features</title><author>Bellisano, Giulia ; Ambrosini-Spaltro, Andrea ; Faa, Gavino ; Ravarino, Alberto ; Piccin, Andrea ; Peer, Irmgard ; Kasal, Armin ; Vittadello, Fabio ; Negri, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3812-2c919fb1c9023e296ed501345bd7fb053ac3ec66b8b778c9b0042cdb5219908f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Case-Control Studies</topic><topic>Cell Nucleus - pathology</topic><topic>cervical cytology</topic><topic>Chromatin - pathology</topic><topic>CIN</topic><topic>Eosinophils - pathology</topic><topic>Female</topic><topic>HSIL</topic><topic>Humans</topic><topic>Papanicolaou Test</topic><topic>Squamous Intraepithelial Lesions of the Cervix - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bellisano, Giulia</creatorcontrib><creatorcontrib>Ambrosini-Spaltro, Andrea</creatorcontrib><creatorcontrib>Faa, Gavino</creatorcontrib><creatorcontrib>Ravarino, Alberto</creatorcontrib><creatorcontrib>Piccin, Andrea</creatorcontrib><creatorcontrib>Peer, Irmgard</creatorcontrib><creatorcontrib>Kasal, Armin</creatorcontrib><creatorcontrib>Vittadello, Fabio</creatorcontrib><creatorcontrib>Negri, Giovanni</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Diagnostic cytopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bellisano, Giulia</au><au>Ambrosini-Spaltro, Andrea</au><au>Faa, Gavino</au><au>Ravarino, Alberto</au><au>Piccin, Andrea</au><au>Peer, Irmgard</au><au>Kasal, Armin</au><au>Vittadello, Fabio</au><au>Negri, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pap-tests with non-hyperchromatic dyskariosis are often associated with squamous intraepithelial lesions of the cervix uteri with eosinophilic features</atitle><jtitle>Diagnostic cytopathology</jtitle><addtitle>Diagn. Cytopathol</addtitle><date>2016-10</date><risdate>2016</risdate><volume>44</volume><issue>10</issue><spage>783</spage><epage>786</epage><pages>783-786</pages><issn>8755-1039</issn><eissn>1097-0339</eissn><abstract>Background
Squamous intraepithelial lesions of the cervix uteri with eosinophilic features (eosinophilic dysplasia, ED) are a peculiar type of dysplasia with metaplastic phenotype which was described in histological specimens. The cytological features of these lesions have not been studied yet.
Methods
Histological samples from 66 women with features of ED and positive p16INK4a staining were included in the study. Within the previous year, all women had at least one pap‐test, whose features were recorded and compared with 31 control samples with high‐grade dysplasia of usual type.
Results
The previous pap‐test showed high‐grade dysplastic cells with non‐hyperchromatic nuclei in 56/66 (84.8%) cases and metaplastic features in 60/66 (90.9%) cases. Conversely, the dysplastic cells of the usual lesions showed non‐hyperchromatic nuclei in 6/31 (19.4%) and metaplastic features in 4/31 (12.9%) cases. Statistical analysis showed significant differences in distribution of the non‐hyperchromatic nuclei (P < 0.001), metaplastic features (P < 0.001), presence of both non‐hyperchromatic nuclei and metaplastic features (P < 0.001) and usual dysplastic features (P < 0.001) among the study and control groups.
Conclusions
A high‐grade squamous intraepithelial lesion with non‐hyperchromatic nuclei or metaplastic features is often found in the pap‐test previous to the histological diagnosis of ED and may represent the cytologic correlate of this particular type of dysplasia. Diagn. Cytopathol. 2016;44:783–786. © 2016 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27407066</pmid><doi>10.1002/dc.23532</doi><tpages>4</tpages></addata></record> |
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| subjects | Case-Control Studies Cell Nucleus - pathology cervical cytology Chromatin - pathology CIN Eosinophils - pathology Female HSIL Humans Papanicolaou Test Squamous Intraepithelial Lesions of the Cervix - pathology |
| title | Pap-tests with non-hyperchromatic dyskariosis are often associated with squamous intraepithelial lesions of the cervix uteri with eosinophilic features |
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